Abstract:
:Metazoans express three unfolded protein response transducers (IRE1, PERK, and ATF6) ubiquitously to cope with endoplasmic reticulum (ER) stress. ATF6 is an ER membrane-bound transcription factor activated by ER stress-induced proteolysis and has been duplicated in mammals. Here, we generated ATF6alpha- and ATF6beta-knockout mice, which developed normally, and then found that their double knockout caused embryonic lethality. Analysis of mouse embryonic fibroblasts (MEFs) deficient in ATF6alpha or ATF6beta revealed that ATF6alpha is solely responsible for transcriptional induction of ER chaperones and that ATF6alpha heterodimerizes with XBP1 for the induction of ER-associated degradation components. ATF6alpha(-/-) MEFs are sensitive to ER stress. Unaltered responses observed in ATF6beta(-/-) MEFs indicate that ATF6beta is not a negative regulator of ATF6alpha. These results demonstrate that ATF6alpha functions as a critical regulator of ER quality control proteins in mammalian cells, in marked contrast to worm and fly cells in which IRE1 is responsible.
journal_name
Dev Celljournal_title
Developmental cellauthors
Yamamoto K,Sato T,Matsui T,Sato M,Okada T,Yoshida H,Harada A,Mori Kdoi
10.1016/j.devcel.2007.07.018subject
Has Abstractpub_date
2007-09-01 00:00:00pages
365-76issue
3eissn
1534-5807issn
1878-1551pii
S1534-5807(07)00300-0journal_volume
13pub_type
杂志文章abstract::Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7-/- T cells are deficient in Fas-receptor-induced apoptosis and that TRPM7 channel activity participates in the apoptotic process and is regulated by caspa...
journal_title:Developmental cell
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abstract::Plasma membrane subdomains enriched in sphingolipids, cholesterol, and signaling proteins are critical for organization of actin, membrane trafficking, and cell polarity, but the role of such domains in cytokinesis in animal cells is unknown. Here, we show that eggs form a plasma membrane domain enriched in gangliosid...
journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2008.05.011
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journal_title:Developmental cell
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journal_title:Developmental cell
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doi:10.1016/j.devcel.2013.10.007
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journal_title:Developmental cell
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doi:10.1016/j.devcel.2013.01.023
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doi:10.1016/j.devcel.2017.12.023
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.07.008
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journal_title:Developmental cell
pub_type: 评论,杂志文章
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journal_title:Developmental cell
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