Abstract:
:In this issue of Developmental Cell, Isabella and Horne-Badovinac (2016) show that Rab10 directs site-specific secretion of basement membrane components, which assemble into fibrils that spool out to elongate the Drosophila egg chamber. These findings establish the basement membrane's active role in tissue sculpting.
journal_name
Dev Celljournal_title
Developmental cellauthors
Jayadev R,Sherwood DRdoi
10.1016/j.devcel.2016.06.028subject
Has Abstractpub_date
2016-07-11 00:00:00pages
1-3issue
1eissn
1534-5807issn
1878-1551pii
S1534-5807(16)30431-2journal_volume
38pub_type
评论,杂志文章abstract::Preventing inappropriate gene expression in time and space is as fundamental as triggering the activation of tissue- or cell-type-specific factors at the correct developmental stage and in the correct cells. Here, we study the impact of Polycomb repressive complex 2 (PRC2) function on HoxA gene regulation. We analyze ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.05.021
更新日期:2019-07-22 00:00:00
abstract::Processing bodies (P bodies) are discrete cytoplasmic foci to which mRNA is routed for degradation. In mammalian cells, they are also associated with miRNA-induced translational silencing and siRNA-induced mRNA degradation. In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting prot...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2005.08.003
更新日期:2005-09-01 00:00:00
abstract::Stem cell differentiation involves a delicate balance of gene expression and transposon repression. In this issue of Developmental Cell, Shibata et al. (2016) show that a PIWI protein expressed in planarian stem cells is inherited by their differentiating descendants to ensure regenerative capacity of the flatworm via...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2016.04.022
更新日期:2016-05-09 00:00:00
abstract::Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2017.02.020
更新日期:2017-03-27 00:00:00
abstract::The Drosophila compound eye consists of approximately 750 independently functioning ommatidia, each containing two photoreceptor subpopulations. The outer photoreceptors participate in motion detection, while the inner photoreceptors contribute to color vision. Although the inner photoreceptors, R7 and R8, terminally ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00156-4
更新日期:2003-06-01 00:00:00
abstract::The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, c...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2007.03.020
更新日期:2007-04-01 00:00:00
abstract::TORC1 is arguably the best-studied regulator of cellular growth in eukaryotes. However, its activity has not been assessed in vivo in developing multicellular organisms. Two studies in this issue of Developmental Cell (Kim et al., 2017; Romero-Pozuelo et al., 2017) surprisingly reveal a patchy, cell-cycle-controlled p...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2017.08.007
更新日期:2017-08-21 00:00:00
abstract::The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors;...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.03.017
更新日期:2019-04-22 00:00:00
abstract::Auxins are a class of phytohormones implicated in virtually every aspect of plant growth and development. Many early plant responses to auxin are apparently mediated by members of a family of Aux/IAA proteins that dimerize with and inhibit members of the auxin response factor (ARF) family of transcription factors. Aux...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/s1534-5807(01)00077-6
更新日期:2001-11-01 00:00:00
abstract::Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A. Propagation of CENP-A chromatin is uncoupled from DNA replication initiating only during mitotic exit. We now demonstrate that ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.10.014
更新日期:2012-01-17 00:00:00
abstract::How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migr...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2021.01.002
更新日期:2021-01-25 00:00:00
abstract::Mutations in Pkd1, encoding polycystin-1 (PC1), cause autosomal-dominant polycystic kidney disease (ADPKD). We show that the carboxy-terminal tail (CTT) of PC1 is released by γ-secretase-mediated cleavage and regulates the Wnt and CHOP pathways by binding the transcription factors TCF and CHOP, disrupting their intera...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.10.028
更新日期:2012-01-17 00:00:00
abstract::It is intuitive to speculate that nutrient availability may influence differentiation of mammalian cells. Nonetheless, a comprehensive complement of the molecular determinants involved in this process has not been elucidated yet. Here, we have investigated how nutrients (glucose) affect skeletal myogenesis. Glucose re...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.02.004
更新日期:2008-05-01 00:00:00
abstract::The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2016.04.019
更新日期:2016-05-23 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive features underlined by major transcriptional and epigenetic reprogramming. However, most studies have focused on the endpoints of the EMT process, and the epistatic hierarchy of the transcriptional networks underlying EMT has remained...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.12.023
更新日期:2019-02-25 00:00:00
abstract::Enhancers are the primary determinants of cell identity, but the regulatory components controlling enhancer turnover during lineage commitment remain largely unknown. Here we compare the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progeni...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.12.014
更新日期:2016-01-11 00:00:00
abstract::It has recently been reported that a common side effect of translation-blocking morpholino antisense oligonucleotides is the induction of a set of innate immune response genes in Xenopus embryos and that splicing-blocking morpholinos lead to unexpected off-target mis-splicing events. Here, we present an analysis of al...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2019.04.019
更新日期:2019-05-20 00:00:00
abstract::Genetically identical cells in culture often exhibit significant variations, or noise, in gene expression, largely due to transcriptional bursting. Halpern et al. (2015) have developed methods to study gene bursting in tissues to find that this transcriptional bursting also occurs in the mammalian liver and may contri...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.03.019
更新日期:2015-04-06 00:00:00
abstract::What coordinates the internal leading and trailing edges in collectively migrating cells is largely unknown. In this issue of Developmental Cell, Barlan et al. (2017) delineate a Fat2/Lar planar signaling pathway at the basal, motile cell-cell contacts of Drosophila egg chamber follicle cells. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2017.02.025
更新日期:2017-03-13 00:00:00
abstract::Efficient regeneration following injury is critical for maintaining tissue function and enabling organismal survival. Cells reconstituting damaged tissue are often generated from resident stem or progenitor cells or from cells that have dedifferentiated and become proliferative. While lineage-tracing studies have defi...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.04.025
更新日期:2015-06-22 00:00:00
abstract::The gastrulating vertebrate embryo develops three germlayers: ectoderm, mesoderm, and endoderm. Zebrafish endoderm differentiation starts with the activation of sox17 by casanova (cas). We report that spg (pou2/Oct4) is essential for endoderm formation. Embryos devoid of maternal and zygotic spg function (MZspg) lack ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00396-4
更新日期:2004-01-01 00:00:00
abstract::The advent of reprogramming and its impact on stem cell biology has renewed interest in lineage restriction in mammalian embryos, the source of embryonic (ES), epiblast (EpiSC), trophoblast (TS), and extraembryonic endoderm (XEN) stem cell lineages. Isolation of specific cell types during stem cell differentiation and...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.01.005
更新日期:2012-04-17 00:00:00
abstract::Intercellular communication is vital to tumor progression. In this issue of Developmental Cell, Bertolini et al. (2020) describe how small extracellular vesicles released from hypoxic mammary tumor cells facilitate intercellular communication, leading to alterations in mitochondrial dynamics and acquisition of invasiv...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.09.027
更新日期:2020-10-26 00:00:00
abstract::FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that comprise the mouse blastocyst. However, ERK signaling dynamics have never been directly visualized in live embryos. To address whether differential signaling is associated with particular cell fates and states, we generated a targe...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.09.030
更新日期:2020-11-09 00:00:00
abstract::Mammary epithelial phagocytosis is critical for removal of apoptotic cells during involution, but the mechanisms governing this process are largely unknown. In this issue of Developmental Cell, Akhtar et al. (2016) provide insight into mechanisms regulating involution, demonstrating that Rac1 drives the switch from di...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2016.08.016
更新日期:2016-09-12 00:00:00
abstract::Myosin phosphatase-targeting subunit 1 (MYPT1) binds to the catalytic subunit of protein phosphatase 1 (PP1C). This binding is believed to target PP1C to specific substrates including myosin II, thus controlling cellular contractility. Surprisingly, we found that during mitosis, mammalian MYPT1 binds to polo-like kina...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.02.013
更新日期:2008-05-01 00:00:00
abstract::Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7-/- T cells are deficient in Fas-receptor-induced apoptosis and that TRPM7 channel activity participates in the apoptotic process and is regulated by caspa...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.04.006
更新日期:2012-06-12 00:00:00
abstract::Passenger proteins migrate from inner centromeres to the spindle midzone during late mitosis, and those described to date are essential both for proper chromosome segregation and for completion of cell cleavage. We have purified and cloned the human passenger protein TD-60, and we here report that it is a member of th...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00205-3
更新日期:2003-08-01 00:00:00
abstract::Recent studies have demonstrated that MyoD initiates a feed-forward regulation of skeletal muscle gene expression, predicting that MyoD binds directly to many genes expressed during differentiation. We have used chromatin immunoprecipitation and high-throughput sequencing to identify genome-wide binding of MyoD in sev...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.02.014
更新日期:2010-04-20 00:00:00
abstract::The Arf tumor suppressor is a key component of the p53 tumor surveillance pathway, and its expression is activated by abnormal proliferation signals. In a recent paper, Lees and coworkers investigate the regulation of Arf expression by E2Fs and demonstrate that in normal cells E2F3 is a pivotal repressor of Arf. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章,评审
doi:10.1016/j.devcel.2004.05.012
更新日期:2004-06-01 00:00:00