Abstract：
:Regulated turnover of integrin receptors is essential for cell adhesion and migration. Pathways selectively regulating β1-integrin recycling are implicated in cancer invasion and metastasis, yet proteins required for the internalization of this pro-invasive integrin remain to be identified. Here, we uncover formin-like 2 (FMNL2) as a critical regulator of β1-integrin internalization downstream of protein kinase C (PKC). PKCα associates with and phosphorylates FMNL2 at S1072 within its Diaphanous autoregulatory region, leading to the release of formin autoinhibition. Phosphorylation of FMNL2 triggers its rapid relocation and promotes its interaction with the cytoplasmic tails of the α-integrin subunits for β1-integrin endocytosis. FMNL2 drives β1-integrin internalization and invasive motility in a phosphorylation-dependent manner, while a FMNL2 mutant defective in actin assembly interferes with β1-integrin endocytosis and cancer cell invasion. Our data establish a role for FMNL2 in the regulation of β1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness.
journal_name
Dev Celljournal_title
Developmental cellauthors
Wang Y,Arjonen A,Pouwels J,Ta H,Pausch P,Bange G,Engel U,Pan X,Fackler OT,Ivaska J,Grosse Rdoi
10.1016/j.devcel.2015.06.015subject
Has Abstractpub_date
2015-08-24 00:00:00pages
475-83issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(15)00422-0journal_volume
34pub_type
杂志文章abstract：:The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting system. Although development of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlying this process remain obscure. Here, we used time-lapse microscopy together with several ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.09.001
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abstract：:Auxins are a class of phytohormones implicated in virtually every aspect of plant growth and development. Many early plant responses to auxin are apparently mediated by members of a family of Aux/IAA proteins that dimerize with and inhibit members of the auxin response factor (ARF) family of transcription factors. Aux...
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abstract：:The TGF-beta family member Nodal is one of the most potent molecules known to an embryo. Studies on Nodal regulation thus far have focused on its transcription, maturation, and interaction with antagonists. Two recent studies on the role of microRNAs (miRNAs) in Nodal signaling now reveal that something important was ...
journal_title：Developmental cell
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journal_title：Developmental cell
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abstract：:Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characterization of the facto...
journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章,评审
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2013.04.004
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.05.026
更新日期：2020-08-10 00:00:00
abstract：:Mammary epithelial phagocytosis is critical for removal of apoptotic cells during involution, but the mechanisms governing this process are largely unknown. In this issue of Developmental Cell, Akhtar et al. (2016) provide insight into mechanisms regulating involution, demonstrating that Rac1 drives the switch from di...
journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章,评审
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更新日期：2009-02-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章,评审
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