Lipoprotein-heparan sulfate interactions in the Hh pathway.

Abstract:

:The Drosophila lipoprotein particle, Lipophorin, bears lipid-linked morphogens on its surface and is required for long-range signaling activity of Wingless and Hedgehog. Heparan sulfate proteoglycans are also critical for trafficking and signaling of these morphogens. Here we show that Lipophorin interacts with the heparan sulfate moieties of the glypicans Dally and Dally-like. Membrane-associated glypicans can recruit Lipophorin to disc tissue, and remain associated with these particles after they are released from the membrane by cleavage of their gpi anchors. The released form of Dally colocalizes with Patched, Hedgehog, and Lipophorin in endosomes and increases Hedgehog signaling efficiency without affecting its distribution. These data suggest that heparan sulfate proteoglycans may influence lipid-linked morphogen signaling, at least in part, by binding to Lipophorin. They further suggest that the complement of proteins present on lipoprotein particles can regulate the activity of morphogens.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Eugster C,Panáková D,Mahmoud A,Eaton S

doi

10.1016/j.devcel.2007.04.019

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

57-71

issue

1

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(07)00180-3

journal_volume

13

pub_type

杂志文章
  • Regulation of activin/nodal signaling by Rap2-directed receptor trafficking.

    abstract::We show that Rap2, a member of the Ras GTPase family, positively regulates Activin/Nodal signaling activity by controlling the trafficking of its receptors. In the absence of ligand activation, Rap2 directs internalized Activin/Nodal receptors into a recycling pathway, thereby preventing their degradation and maintain...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.05.004

    authors: Choi SC,Kim GH,Lee SJ,Park E,Yeo CY,Han JK

    更新日期:2008-07-01 00:00:00

  • Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa.

    abstract::Septins are polymerizing GTP binding proteins required for cortical organization during cytokinesis and other cellular processes. A mammalian septin gene Sept4 is expressed mainly in postmitotic neural cells and postmeiotic male germ cells. In mouse and human spermatozoa, SEPT4 and other septins are found in the annul...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2004.12.005

    authors: Ihara M,Kinoshita A,Yamada S,Tanaka H,Tanigaki A,Kitano A,Goto M,Okubo K,Nishiyama H,Ogawa O,Takahashi C,Itohara S,Nishimune Y,Noda M,Kinoshita M

    更新日期:2005-03-01 00:00:00

  • Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium.

    abstract::Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2005.11.016

    authors: Shimada Y,Yonemura S,Ohkura H,Strutt D,Uemura T

    更新日期:2006-02-01 00:00:00

  • The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage.

    abstract::The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors;...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.03.017

    authors: Baek S,Oh TG,Secker G,Sutton DL,Okuda KS,Paterson S,Bower NI,Toubia J,Koltowska K,Capon SJ,Baillie GJ,Simons C,Muscat GEO,Lagendijk AK,Smith KA,Harvey NL,Hogan BM

    更新日期:2019-04-22 00:00:00

  • ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development.

    abstract::Cell polarity plays a key role in the development of the central nervous system (CNS). Interestingly, disruption of cell polarity is seen in many cancers. ASPP2 is a haplo-insufficient tumor suppressor and an activator of the p53 family. In this study, we show that ASPP2 controls the polarity and proliferation of neur...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2010.06.003

    authors: Sottocornola R,Royer C,Vives V,Tordella L,Zhong S,Wang Y,Ratnayaka I,Shipman M,Cheung A,Gaston-Massuet C,Ferretti P,Molnár Z,Lu X

    更新日期:2010-07-20 00:00:00

  • Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites.

    abstract::The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLA...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.05.011

    authors: González Montoro A,Auffarth K,Hönscher C,Bohnert M,Becker T,Warscheid B,Reggiori F,van der Laan M,Fröhlich F,Ungermann C

    更新日期:2018-06-04 00:00:00

  • A major epigenetic programming mechanism guided by piRNAs.

    abstract::A central enigma in epigenetics is how epigenetic factors are guided to specific genomic sites for their function. Previously, we reported that a Piwi-piRNA complex associates with the piRNA-complementary site in the Drosophila genome and regulates its epigenetic state. Here, we report that Piwi-piRNA complexes bind t...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.01.023

    authors: Huang XA,Yin H,Sweeney S,Raha D,Snyder M,Lin H

    更新日期:2013-03-11 00:00:00

  • PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress.

    abstract::Cell and organelle membranes consist of a complex mixture of phospholipids (PLs) that determine their size, shape, and function. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes, yet how cells sense and regulate its levels in vivo remains unclear. Here we show that PCYT1A, the rate-li...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.04.012

    authors: Haider A,Wei YC,Lim K,Barbosa AD,Liu CH,Weber U,Mlodzik M,Oras K,Collier S,Hussain MM,Dong L,Patel S,Alvarez-Guaita A,Saudek V,Jenkins BJ,Koulman A,Dymond MK,Hardie RC,Siniossoglou S,Savage DB

    更新日期:2018-05-21 00:00:00

  • DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation.

    abstract::DNA crosslinking agents are commonly used in cancer chemotherapy; however, responses of normal tissues to these agents have not been widely investigated. We reveal in mouse interfollicular epidermal, mammary and hair follicle epithelia that genotoxicity does not promote apoptosis but paradoxically induces hyperplasia ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2020.09.021

    authors: Seldin L,Macara IG

    更新日期:2020-12-07 00:00:00

  • Genomic analysis of gastrulation and organogenesis in the mouse.

    abstract::We developed a comprehensive dataset that samples the mouse transcriptome every 6 hr, from gastrulation through organogenesis. We observe an abrupt increase in overall transcript diversity at the onset of organogenesis (e8.0); the genes that comprise these changes are preferentially clustered along chromosome 7 and co...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2007.10.004

    authors: Mitiku N,Baker JC

    更新日期:2007-12-01 00:00:00

  • Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier.

    abstract::Pericytes are critical for cerebrovascular maturation and development of the blood-brain barrier (BBB), but their role in maintenance of the adult BBB, and how CNS pericytes differ from those of other tissues, is less well understood. We show that the forkhead transcription factor Foxf2 is specifically expressed in pe...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2015.05.008

    authors: Reyahi A,Nik AM,Ghiami M,Gritli-Linde A,Pontén F,Johansson BR,Carlsson P

    更新日期:2015-07-06 00:00:00

  • Luminal mitosis drives epithelial cell dispersal within the branching ureteric bud.

    abstract::The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting system. Although development of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlying this process remain obscure. Here, we used time-lapse microscopy together with several ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.09.001

    authors: Packard A,Georgas K,Michos O,Riccio P,Cebrian C,Combes AN,Ju A,Ferrer-Vaquer A,Hadjantonakis AK,Zong H,Little MH,Costantini F

    更新日期:2013-11-11 00:00:00

  • p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate.

    abstract::The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.02.005

    authors: Nyeng P,Heilmann S,Löf-Öhlin ZM,Pettersson NF,Hermann FM,Reynolds AB,Semb H

    更新日期:2019-04-08 00:00:00

  • Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal.

    abstract::Large intergenic noncoding (linc) RNAs constitute a new dimension of posttranscriptional gene regulation. In this issue of Developmental Cell, Wang et al. (2013) find that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to trap miR-145, thus regulating core pluripotency factors Oct...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2013.03.020

    authors: Cheng EC,Lin H

    更新日期:2013-04-15 00:00:00

  • Neutrophils, wounds, and cancer progression.

    abstract::Chronic inflammation is associated with tumorigenesis, but how acute inflammation affects the tumor microenvironment is less known. Recently, Antonio et al. (2015) found that neutrophils attracted to an acute wound such as a biopsy drive cell proliferation of nearby pre-neoplastic cells, suggesting that acute wounds m...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2015.07.005

    authors: Rosowski EE,Huttenlocher A

    更新日期:2015-07-27 00:00:00

  • SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion.

    abstract::Migrating fibroblasts undergo contact inhibition of locomotion (CIL), a process that was discovered five decades ago and still is not fully understood at the molecular level. We identify the Slit2-Robo4-srGAP2 signaling network as a key regulator of CIL in fibroblasts. CIL involves highly dynamic contact protrusions w...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2015.09.002

    authors: Fritz RD,Menshykau D,Martin K,Reimann A,Pontelli V,Pertz O

    更新日期:2015-10-12 00:00:00

  • Less Is More: Ditching Mitochondria Saves Hypoxic Cartilage.

    abstract::In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2019.05.030

    authors: Long F

    更新日期:2019-06-03 00:00:00

  • Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains.

    abstract::Wnt/β-catenin signaling plays critical roles during embryogenesis, tissue homeostasis, and regeneration. How Wnt-receptor complex activity is regulated is not yet fully understood. Here, we identify the Ly6 family protein LY6/PLAUR domain-containing 6 (Lypd6) as a positive feedback regulator of Wnt/β-catenin signaling...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.07.020

    authors: Özhan G,Sezgin E,Wehner D,Pfister AS,Kühl SJ,Kagermeier-Schenk B,Kühl M,Schwille P,Weidinger G

    更新日期:2013-08-26 00:00:00

  • Quantitative modeling in cell biology: what is it good for?

    abstract::Recently, there has been a surge in the number of pioneering studies combining experiments with quantitative modeling to explain both relatively simple modules of molecular machinery of the cell and to achieve system-level understanding of cellular networks. Here we discuss the utility and methods of modeling and revi...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2006.08.004

    authors: Mogilner A,Wollman R,Marshall WF

    更新日期:2006-09-01 00:00:00

  • Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting.

    abstract::Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.01.020

    authors: Centanin L,Dekanty A,Romero N,Irisarri M,Gorr TA,Wappner P

    更新日期:2008-04-01 00:00:00

  • Hedgehog signaling in development and cancer.

    abstract::The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signalin...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2008.11.010

    authors: Jiang J,Hui CC

    更新日期:2008-12-01 00:00:00

  • Spatial regulation of Wingless morphogen distribution and signaling by Dally-like protein.

    abstract::Wingless (Wg) is a morphogen required for the patterning of many Drosophila tissues. Several lines of evidence implicate heparan sulfate-modified proteoglycans (HSPGs) such as Dally-like protein (Dlp) in the control of Wg distribution and signaling. We show that dlp is required to limit Wg levels in the matrix, contra...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2004.08.004

    authors: Kirkpatrick CA,Dimitroff BD,Rawson JM,Selleck SB

    更新日期:2004-10-01 00:00:00

  • Cellular and molecular mechanisms of border cell migration analyzed using time-lapse live-cell imaging.

    abstract::Border cells in the Drosophila ovary originate within an epithelium, detach from it, invade neighboring nurse cells, and migrate as a coherent cluster. This migration has served as a useful genetic model for understanding epithelial cell motility. The prevailing model of growth factor-mediated chemotaxis in general, a...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2007.03.021

    authors: Prasad M,Montell DJ

    更新日期:2007-06-01 00:00:00

  • ORP-Mediated ER Contact with Endocytic Sites Facilitates Actin Polymerization.

    abstract::Oxysterol binding protein-related proteins (ORPs) are conserved lipid binding polypeptides, enriched at ER contacts sites. ORPs promote non-vesicular lipid transport and work as lipid sensors in the context of many cellular tasks, but the determinants of their distinct localization and function are not understood. Her...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2017.10.031

    authors: Encinar Del Dedo J,Idrissi FZ,Fernandez-Golbano IM,Garcia P,Rebollo E,Krzyzanowski MK,Grötsch H,Geli MI

    更新日期:2017-12-04 00:00:00

  • Nuclear architecture--an island no more.

    abstract::The eukaryotic nucleus has been the neglected child of cell biology. The "International Symposium on Functional Organization of the Nucleus" held in January on Awaji Island, Japan, highlighted recent work on nuclear organization and function. Emerging from this conference was a holistic view in which diverse chemical ...

    journal_title:Developmental cell

    pub_type:

    doi:10.1016/j.devcel.2007.02.014

    authors: Dernburg AF,Misteli T

    更新日期:2007-03-01 00:00:00

  • Specific Isoforms of the Guanine-Nucleotide Exchange Factor dPix Couple Neuromuscular Synapse Growth to Muscle Growth.

    abstract::Developmental growth requires coordination between the growth rates of individual tissues and organs. Here, we examine how Drosophila neuromuscular synapses grow to match the size of their target muscles. We show that changes in muscle growth driven by autonomous modulation of insulin receptor signaling produce corres...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2020.05.015

    authors: Ho CH,Treisman JE

    更新日期:2020-07-06 00:00:00

  • EGF receptor signaling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulation.

    abstract::In Drosophila, commitment of a cell to a sense organ precursor (SOP) fate requires bHLH proneural transcription factor upregulation, a process that depends in most cases on the interplay of proneural gene autoregulation and inhibitory Notch signaling. A subset of SOPs are selected by a recruitment pathway involving EG...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2004.09.015

    authors: zur Lage PI,Powell LM,Prentice DR,McLaughlin P,Jarman AP

    更新日期:2004-11-01 00:00:00

  • Sizing up lung stem cells.

    abstract::Mammalian lungs are comprised of conducting airways and alveoli. How the distinct epithelial linings of these two zones are differentially specified and maintained is not fully understood. In this issue of Developmental Cell, two groups find critical roles for the Hippo pathway in regulation of lung progenitor cell di...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2014.07.002

    authors: Rock JR

    更新日期:2014-07-28 00:00:00

  • Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression.

    abstract::Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in regulation of both the Hippo-Yap and Rac1-Pak1 pathways. Using genetically engineered murine liver models, we show that co-deletion of Rac1 with Nf2 blocks tumor initiation but paradoxically exacerbates hepatomegaly induced by N...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.09.027

    authors: Shi Y,Bollam SR,White SM,Laughlin SZ,Graham GT,Wadhwa M,Chen H,Nguyen C,Vitte J,Giovannini M,Toretsky J,Yi C

    更新日期:2016-11-21 00:00:00

  • Nuclear Deformation Lets Cells Gauge Their Physical Confinement.

    abstract::How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migr...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2021.01.002

    authors: Long JT,Lammerding J

    更新日期:2021-01-25 00:00:00