Regulation of angiogenesis by oxygen and metabolism.

abstract：:The adaptor complex AP-2 plays an important role in cargo selection and clathrin lattice formation during clathrin-mediated endocytosis. In a recent issue of Molecular Cell, Honing et al. demonstrate that high-affinity AP-2 membrane association is achieved through a combination of low-affinity interactions with membra...

journal_title：Developmental cell

authors： Gaidarov I,Keen JH

更新日期：2005-06-01 00:00:00

abstract：:DNA crosslinking agents are commonly used in cancer chemotherapy; however, responses of normal tissues to these agents have not been widely investigated. We reveal in mouse interfollicular epidermal, mammary and hair follicle epithelia that genotoxicity does not promote apoptosis but paradoxically induces hyperplasia ...

journal_title：Developmental cell

authors： Seldin L,Macara IG

更新日期：2020-12-07 00:00:00

abstract：:Neutrophils, in response to a chemoattractant gradient, undergo dynamic F-actin remodeling, a process important for their directional migration or chemotaxis. However, signaling mechanisms for chemoattractants to regulate the process are incompletely understood. Here, we characterized chemoattractant-activated signali...

journal_title：Developmental cell

authors： Tang W,Zhang Y,Xu W,Harden TK,Sondek J,Sun L,Li L,Wu D

更新日期：2011-12-13 00:00:00

abstract：:Formation of the embryonic heart tube requires the medial migration and merger of bilateral precursor populations. A new study of zebrafish cardiogenesis published in this issue of Developmental Cell indicates that precursor migration involves formation of a coherent epithelium and that fibronectin plays an important ...

journal_title：Developmental cell

authors： Glickman NS,Yelon D

更新日期：2004-03-01 00:00:00

abstract：:The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of these isolated neurons. Their profiles were similarly...

journal_title：Developmental cell

authors： Hattori Y,Usui T,Satoh D,Moriyama S,Shimono K,Itoh T,Shirahige K,Uemura T

更新日期：2013-12-09 00:00:00

abstract：:Polarized delivery of signaling and adhesion molecules to the leading edge is required for directional migration of cells. Here, we describe a role for the PIP(2)-synthesizing enzyme, PIPKIγi2, in regulation of exocyst complex control of cell polarity and polarized integrin trafficking during migration. Loss of PIPKIγ...

journal_title：Developmental cell

authors： Thapa N,Sun Y,Schramp M,Choi S,Ling K,Anderson RA

更新日期：2012-01-17 00:00:00

abstract：:We developed a comprehensive dataset that samples the mouse transcriptome every 6 hr, from gastrulation through organogenesis. We observe an abrupt increase in overall transcript diversity at the onset of organogenesis (e8.0); the genes that comprise these changes are preferentially clustered along chromosome 7 and co...

journal_title：Developmental cell

authors： Mitiku N,Baker JC

更新日期：2007-12-01 00:00:00

abstract：:Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essent...

journal_title：Developmental cell

authors： Miao R,Li M,Zhang Q,Yang C,Wang X

更新日期：2020-01-06 00:00:00

abstract：:Yeast cells track gradients of pheromones to locate mating partners. Intuition suggests that uniform distribution of pheromone receptors over the cell surface would yield optimal gradient sensing. However, yeast cells display polarized receptors. The benefit of such polarization was unknown. During gradient tracking, ...

journal_title：Developmental cell

authors： McClure AW,Minakova M,Dyer JM,Zyla TR,Elston TC,Lew DJ

更新日期：2015-11-23 00:00:00

abstract：:Renewing tissues have the remarkable ability to continually produce both proliferative progenitor and specialized differentiated cell types. How are complex milieus of microenvironmental signals interpreted to coordinate tissue-cell-type composition? Here, we investigate the responses of intestinal epithelium to indiv...

journal_title：Developmental cell

authors： Sanman LE,Chen IW,Bieber JM,Steri V,Trentesaux C,Hann B,Klein OD,Wu LF,Altschuler SJ

更新日期：2021-01-15 00:00:00

abstract：:PTEN is one of the most commonly lost tumor suppressors in human cancer and is known to inhibit insulin signaling. Eph receptor tyrosine kinases (RTKs) have also been implicated in cancer formation and progression, and they have diverse functions, including nervous and vascular system development. We show that in C. e...

journal_title：Developmental cell

authors： Brisbin S,Liu J,Boudreau J,Peng J,Evangelista M,Chin-Sang I

更新日期：2009-10-01 00:00:00

abstract：:Autophagy is the major cellular process responsible for bulk cytoplasmic degradation. Two reports in this issue of Developmental Cell describe how both PI3 kinase and TOR signaling in Drosophila are critical for controlling autophagy in response to developmental and environmental cues. ...

journal_title：Developmental cell

authors： Grewal SS,Saucedo LJ

更新日期：2004-08-01 00:00:00

abstract：:Transmission of the human parasite Brugia malayi relies on the sustained production of larvae in blood. In this issue of Developmental Cell,Foray et al. (2018) use methods developed in the model nematode C. elegans to reveal how a symbiotic bacterium supports the female germ cell development underlying this massive fe...

journal_title：Developmental cell

authors： Haag ES,Lo TW

更新日期：2018-04-23 00:00:00

abstract：:The quiescent center (QC) maintains the activity of the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaining the low rate of QC cell division remain poorly understood. Here, we identified a R2R3-MYB transcription factor, BRAVO (BRASSINOSTEROIDS AT VASCULAR AND ORGANIZING CE...

journal_title：Developmental cell

authors： Vilarrasa-Blasi J,González-García MP,Frigola D,Fàbregas N,Alexiou KG,López-Bigas N,Rivas S,Jauneau A,Lohmann JU,Benfey PN,Ibañes M,Caño-Delgado AI

更新日期：2014-07-14 00:00:00

abstract：:Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here...

journal_title：Developmental cell

authors： Bordt EA,Clerc P,Roelofs BA,Saladino AJ,Tretter L,Adam-Vizi V,Cherok E,Khalil A,Yadava N,Ge SX,Francis TC,Kennedy NW,Picton LK,Kumar T,Uppuluri S,Miller AM,Itoh K,Karbowski M,Sesaki H,Hill RB,Polster BM

更新日期：2017-03-27 00:00:00

abstract：:The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network plays fundamental roles in cell growth, survival, and migration and is frequently activated in cancer. Here, we show that the activities of the signaling network propagate as coordinated waves, biased by growth factor, which drive actin-based ...

journal_title：Developmental cell

authors： Zhan H,Bhattacharya S,Cai H,Iglesias PA,Huang CH,Devreotes PN

更新日期：2020-09-14 00:00:00

abstract：:Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to si...

journal_title：Developmental cell

authors： Graml V,Studera X,Lawson JLD,Chessel A,Geymonat M,Bortfeld-Miller M,Walter T,Wagstaff L,Piddini E,Carazo Salas RE

更新日期：2014-10-27 00:00:00

abstract：:In Drosophila, commitment of a cell to a sense organ precursor (SOP) fate requires bHLH proneural transcription factor upregulation, a process that depends in most cases on the interplay of proneural gene autoregulation and inhibitory Notch signaling. A subset of SOPs are selected by a recruitment pathway involving EG...

journal_title：Developmental cell

authors： zur Lage PI,Powell LM,Prentice DR,McLaughlin P,Jarman AP

更新日期：2004-11-01 00:00:00

abstract：:During the first five rounds of cell division in the mouse embryo, spindles assemble in the absence of centrioles. Spindle formation initiates around chromosomes, but the microtubule nucleating process remains unclear. Here we demonstrate that Plk4, a protein kinase known as a master regulator of centriole formation, ...

journal_title：Developmental cell

authors： Coelho PA,Bury L,Sharif B,Riparbelli MG,Fu J,Callaini G,Glover DM,Zernicka-Goetz M

更新日期：2013-12-09 00:00:00

abstract：:Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H₂O₂)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly w...

journal_title：Developmental cell

authors： DeGennaro M,Hurd TR,Siekhaus DE,Biteau B,Jasper H,Lehmann R

更新日期：2011-02-15 00:00:00

abstract：:In this issue of Developmental Cell, Chakraborty et al. report that efficient advancement through G1/S phase requires the downregulation of Nup96 levels during M phase. The authors show that oscillations in Nup96 levels plays a key role in maintaining normal cell proliferation, likely by regulating the export of speci...

journal_title：Developmental cell

authors： Wozniak RW,Goldfarb DS

更新日期：2008-11-01 00:00:00

abstract：:The Rho GTPase Cdc42 is essential for polarized growth of budding yeast. Temporal control of Cdc42 depends partly on the activity of its GTPase-activating proteins (GAPs). In this issue of Developmental Cell, Saito et al. report that Cdc42 GAP activity is regulated by the phospholipid composition of the bud-tip membra...

journal_title：Developmental cell

authors： Menon AK

更新日期：2007-11-01 00:00:00

abstract：:Although we know that mesenchymal progenitors give rise to nephrons in the kidney, how they balance self-renewal versus differentiation is still unclear. In this issue of Developmental Cell, Chen et al. (2015) show that nephron progenitors age, but not necessarily irreversibly: old progenitors can be "rejuvenated" by ...

journal_title：Developmental cell

authors： Little MH

更新日期：2015-10-12 00:00:00

abstract：:Activation of Cyclin D/Cdk4 stimulates progression through the G1-S phase of the cell cycle in many organisms. In Drosophila, Cyclin D/Cdk4 also induces cell growth independently of cell cycle progression. In this issue of Developmental Cell, Frei and Edgar reveal that Cyclin D/Cdk4-stimulated growth requires Hph, a p...

journal_title：Developmental cell

authors： Duronio RJ

更新日期：2004-02-01 00:00:00

abstract：:Theoretical modeling is central to elucidating underlying principles of emergent properties of complex systems. In cell and developmental biology, the last 15 years have witnessed a convergence of empirical and modeling approaches for fresh perspectives. The role of cell division in coordinating size, shape, and fate ...

journal_title：Developmental cell

authors： Bellaïche Y

更新日期：2016-09-26 00:00:00

abstract：:The shape of most complex organ systems arises from the directed migration of cohesive groups of cells. Here, we dissect the role of the chemokine guidance receptor Cxcr4b in regulating the collective migration of one such cohesive tissue, the zebrafish lateral line primordium. Using in vivo imaging, we show that the ...

journal_title：Developmental cell

authors： Haas P,Gilmour D

更新日期：2006-05-01 00:00:00

abstract：:In this issue of Developmental Cell, Ren et al. (2019) identify the embryonic origin of cardiac pacemaker cells in zebrafish and implicate Wnt5b in promoting their differentiation. Furthermore, canonical Wnt activation in human stem cell-derived cardiac progenitors produces functional pacemaker cells in vitro, advanci...

journal_title：Developmental cell

authors： Burns CG,Burns CE

更新日期：2019-09-23 00:00:00

abstract：:Reporting in Nature, Sanders et al. (2013) implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb. Actin-based filopodia transport Shh from producing cells, while filopodia of responding cells bear Cdon and Boc: coreceptors in the Shh pathway. These findings suggest a new mechanism of ligand m...

journal_title：Developmental cell

authors： McMahon AP,Hasso SM

更新日期：2013-05-28 00:00:00

abstract：:The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA...

journal_title：Developmental cell

authors： Desrochers LM,Antonyak MA,Cerione RA

更新日期：2016-05-23 00:00:00

abstract：:The AMP-stimulated protein kinase regulates epithelial polarity under conditions of energy depletion by phosphorylating the myosin regulatory light chain. In this issue of Developmental Cell, Mirouse et al. demonstrate that dystroglycan and perlecan, an extracellular matrix receptor and its ligand, help localize myosi...

journal_title：Developmental cell

authors： Zhang L,Seo-Mayer P,Caplan MJ

更新日期：2009-01-01 00:00:00