Filopodia: the cellular quills of hedgehog signaling?

abstract：:Signaling circuits often coordinate cellular membranes and actin filaments at distinct sites to direct cell behavior. In this issue of Developmental Cell, Bershteyn et al. outline how the molecular scaffold protein, MIM, which bends membranes and binds actin filaments, is at the middle of one such circuit to regulate ...

journal_title：Developmental cell

authors： Kozminski KG,Schafer DA

更新日期：2010-08-17 00:00:00

abstract：:In Drosophila, left/right (LR) asymmetry is apparent in the directional looping of the gut and male genitalia. The dextral orientation of the organs depends on the activity of a single gene, MyosinID (myoID), whose mutation leads to a fully inverted LR axis, thus revealing the activity of a recessive sinistral pathway...

journal_title：Developmental cell

authors： Coutelis JB,Géminard C,Spéder P,Suzanne M,Petzoldt AG,Noselli S

更新日期：2013-01-14 00:00:00

abstract：:In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targetin...

journal_title：Developmental cell

authors： Kim DH,Park MJ,Gwon GH,Silkov A,Xu ZY,Yang EC,Song S,Song K,Kim Y,Yoon HS,Honig B,Cho W,Cho Y,Hwang I

更新日期：2014-09-08 00:00:00

abstract：:How cold-blooded animals acclimate to temperature and what determines the limits of their viable temperature range are not understood. Here, we show that Drosophila alter their dietary preference from yeast to plants when temperatures drop below 15°C and that the different lipids present in plants improve survival at ...

journal_title：Developmental cell

authors： Brankatschk M,Gutmann T,Knittelfelder O,Palladini A,Prince E,Grzybek M,Brankatschk B,Shevchenko A,Coskun Ü,Eaton S

更新日期：2018-09-24 00:00:00

abstract：:The ability of the death ligand TRAIL to induce tumor cell apoptosis has led to the development of TRAIL-based cancer therapies. Reporting recently in Molecular Cell, Lu et al. (2014) show that the basis for differential TRAIL responses involves clustering of death receptor complexes by E-cadherin and the actin cytosk...

journal_title：Developmental cell

authors： Gallegos LL,Brugge JS

更新日期：2014-07-14 00:00:00

abstract：:The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these ...

journal_title：Developmental cell

authors： Nyeng P,Heilmann S,Löf-Öhlin ZM,Pettersson NF,Hermann FM,Reynolds AB,Semb H

更新日期：2019-04-08 00:00:00

abstract：:Dominant VAPB mutations are implicated in neurodegenerative disease, including amyotrophic lateral sclerosis and spinal muscular atrophy. In the current issue, Han et al. (2012) uncover a mechanism through which the secreted VAPB MSP domain regulates actin organization and mitochondrial function in muscle cells throug...

journal_title：Developmental cell

authors： Long JB,Van Vactor D

更新日期：2012-02-14 00:00:00

abstract：:The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network plays fundamental roles in cell growth, survival, and migration and is frequently activated in cancer. Here, we show that the activities of the signaling network propagate as coordinated waves, biased by growth factor, which drive actin-based ...

journal_title：Developmental cell

authors： Zhan H,Bhattacharya S,Cai H,Iglesias PA,Huang CH,Devreotes PN

更新日期：2020-09-14 00:00:00

abstract：:In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes an...

journal_title：Developmental cell

authors： Karsenty G,Wagner EF

更新日期：2002-04-01 00:00:00

abstract：:Egg production declines with age in many species, a process linked with stem cell loss. Diet-dependent signaling has emerged as critical for stem cell maintenance during aging. Follicle stem cells (FSCs) in the Drosophila ovary are exquisitely responsive to diet-induced signals including Hedgehog (Hh) and insulin-IGF ...

journal_title：Developmental cell

authors： Singh T,Lee EH,Hartman TR,Ruiz-Whalen DM,O'Reilly AM

更新日期：2018-09-24 00:00:00

abstract：:During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell-cycle progression, and cytokinesis. Rac1 null cells migrate markedly less efficiently, but s...

journal_title：Developmental cell

authors： Li A,Ma Y,Yu X,Mort RL,Lindsay CR,Stevenson D,Strathdee D,Insall RH,Chernoff J,Snapper SB,Jackson IJ,Larue L,Sansom OJ,Machesky LM

更新日期：2011-10-18 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and Angiopoietin 1 (Ang1) are both potent proangiogenic factors, but, whereas VEGF causes vascular permeability, Ang1 stabilizes blood vessels and protects them from VEGF-induced plasma leakage. The antivascular permeability mechanisms deployed by Ang1 are still undefined. Her...

journal_title：Developmental cell

authors： Gavard J,Patel V,Gutkind JS

更新日期：2008-01-01 00:00:00

abstract：:Metazoans express three unfolded protein response transducers (IRE1, PERK, and ATF6) ubiquitously to cope with endoplasmic reticulum (ER) stress. ATF6 is an ER membrane-bound transcription factor activated by ER stress-induced proteolysis and has been duplicated in mammals. Here, we generated ATF6alpha- and ATF6beta-k...

journal_title：Developmental cell

authors： Yamamoto K,Sato T,Matsui T,Sato M,Okada T,Yoshida H,Harada A,Mori K

更新日期：2007-09-01 00:00:00

abstract：:In this issue of Developmental Cell, Isabella and Horne-Badovinac (2016) show that Rab10 directs site-specific secretion of basement membrane components, which assemble into fibrils that spool out to elongate the Drosophila egg chamber. These findings establish the basement membrane's active role in tissue sculpting. ...

journal_title：Developmental cell

authors： Jayadev R,Sherwood DR

更新日期：2016-07-11 00:00:00

abstract：:The majority of excitatory synaptic transmission in the brain occurs at dendritic spines, which are actin-rich protrusions on the dendrites. The asymmetric nature of these structures suggests that proteins regulating cell polarity might be involved in their formation. Indeed, the polarity protein PAR-3 is required for...

journal_title：Developmental cell

authors： Zhang H,Macara IG

更新日期：2008-02-01 00:00:00

abstract：:In vertebrates, the microtubule binding protein TPX2 is required for meiotic and mitotic spindle assembly. TPX2 is also known to bind to and activate Aurora A kinase and target it to the spindle. However, the relationship between the TPX2-Aurora A interaction and the role of TPX2 in spindle assembly is unclear. Here, ...

journal_title：Developmental cell

authors： Ozlü N,Srayko M,Kinoshita K,Habermann B,O'toole ET,Müller-Reichert T,Schmalz N,Desai A,Hyman AA

更新日期：2005-08-01 00:00:00

abstract：:The orientation of the mitotic spindle plays a key role in determining whether a polarized cell will divide symmetrically or asymmetrically. In most cell types, cytoplasmic dynein plays a critical role in spindle orientation. However, how dynein directs opposite spindle poles toward distinct and predetermined cell end...

journal_title：Developmental cell

authors： Grava S,Schaerer F,Faty M,Philippsen P,Barral Y

更新日期：2006-04-01 00:00:00

abstract：:T-box genes encode DNA binding transcription factors known to regulate a wide variety of developmental processes during embryogenesis and are present in the genomes of all multicellular animals. Indeed, alongside other more familiar families of developmental regulators such as Hox, Sox, and Pax, T-box genes constitute...

journal_title：Developmental cell

authors： Gibson-Brown JJ

更新日期：2002-11-01 00:00:00

abstract：:Somatic muscle formation in Drosophila requires fusion of muscle founder cells with fusion-competent myoblasts. In a genetic screen for genes that control muscle development, we identified antisocial (ants), a gene that encodes an ankyrin repeat-, TPR repeat-, and RING finger-containing protein, required for myoblast ...

journal_title：Developmental cell

authors： Chen EH,Olson EN

更新日期：2001-11-01 00:00:00

abstract：:The dorsoventral axis of the Drosophila embryo is patterned by a gradient of bone morphogenetic protein (BMP) ligands. In a process requiring at least three additional extracellular proteins, a broad domain of weak signaling forms and then abruptly sharpens into a narrow dorsal midline peak. Using experimental and com...

journal_title：Developmental cell

authors： Mizutani CM,Nie Q,Wan FY,Zhang YT,Vilmos P,Sousa-Neves R,Bier E,Marsh JL,Lander AD

更新日期：2005-06-01 00:00:00

abstract：:The complex muscle patterns of higher organisms arise as migrating myoblasts are guided toward and connect with specific attachment sites. We review here the current understanding of myotube migration, focusing on its dynamic nature and the few molecular cues that have been identified to date. Much of this knowledge c...

journal_title：Developmental cell

authors： Schnorrer F,Dickson BJ

更新日期：2004-07-01 00:00:00

abstract：:By functioning as an enzyme cofactor, hemoglobin component, and gene regulator, heme is vital for life. One mode of heme-regulated transcription involves amplifying the activity of GATA-1, a key determinant of erythrocyte differentiation. To discover biological consequences of the metal cofactor-transcription factor m...

journal_title：Developmental cell

authors： Tanimura N,Liao R,Wilson GM,Dent MR,Cao M,Burstyn JN,Hematti P,Liu X,Zhang Y,Zheng Y,Keles S,Xu J,Coon JJ,Bresnick EH

更新日期：2018-09-10 00:00:00

abstract：:Human centromeres are defined by alpha satellite DNA arrays that are distinct and chromosome specific. Most human chromosomes contain multiple alpha satellite arrays that are competent for centromere assembly. Here, we show that human centromeres are defined by chromosome-specific RNAs linked to underlying organizatio...

journal_title：Developmental cell

authors： McNulty SM,Sullivan LL,Sullivan BA

更新日期：2017-08-07 00:00:00

abstract：:In this issue of Developmental Cell, Gibson and colleagues (Ramanathan et al., 2019) investigate the relationship between size and shape in epithelial cells. They find that cell size impacts cell shape, with unexpected consequences for epithelial growth and morphogenesis, particularly the clonal dynamics of epithelial...

journal_title：Developmental cell

authors： Thompson BJ

更新日期：2019-10-07 00:00:00

abstract：:Our vasculature plays diverse and critical roles in homeostasis and disease. In recent decades, the use of zebrafish has driven our understanding of vascular development into new areas, identifying new genes and mechanisms controlling vessel formation and allowing unprecedented observation of the cellular and molecula...

journal_title：Developmental cell

authors： Hogan BM,Schulte-Merker S

更新日期：2017-09-25 00:00:00

abstract：:Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here, we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacial development. Str...

journal_title：Developmental cell

authors： Zalc A,Rattenbach R,Auradé F,Cadot B,Relaix F

更新日期：2015-04-06 00:00:00

abstract：:Drosophila proprioceptors (chordotonal organs) are structured as a linear array of four lineage-related cells: a neuron, a glial cell, and two accessory cells, called cap and ligament, between which the neuron is stretched. To function properly as stretch receptors, chordotonal organs must be stably anchored at both e...

journal_title：Developmental cell

authors： Inbal A,Volk T,Salzberg A

更新日期：2004-08-01 00:00:00

abstract：:Little is known about the mechanisms governing neonatal growth and maturation of organs. Here we demonstrate that calcineurin/Nuclear Factor of Activated T cells (Cn/NFAT) signaling regulates neonatal pancreatic development in mouse and human islets. Inactivation of calcineurin b1 (Cnb1) in mouse islets impaired dense...

journal_title：Developmental cell

authors： Goodyer WR,Gu X,Liu Y,Bottino R,Crabtree GR,Kim SK

更新日期：2012-07-17 00:00:00

abstract：:The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLA...

journal_title：Developmental cell

authors： González Montoro A,Auffarth K,Hönscher C,Bohnert M,Becker T,Warscheid B,Reggiori F,van der Laan M,Fröhlich F,Ungermann C

更新日期：2018-06-04 00:00:00

abstract：:Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H₂O₂)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly w...

journal_title：Developmental cell

authors： DeGennaro M,Hurd TR,Siekhaus DE,Biteau B,Jasper H,Lehmann R

更新日期：2011-02-15 00:00:00