Abstract:
:Somatic muscle formation in Drosophila requires fusion of muscle founder cells with fusion-competent myoblasts. In a genetic screen for genes that control muscle development, we identified antisocial (ants), a gene that encodes an ankyrin repeat-, TPR repeat-, and RING finger-containing protein, required for myoblast fusion. In ants mutant embryos, founder cells and fusion-competent myoblasts are properly specified and patterned, but they are unable to form myotubes. ANTS, which is expressed specifically in founder cells, interacts with the cytoplasmic domain of Dumbfounded, a founder cell transmembrane receptor, and with Myoblast city, a cytoskeletal protein, both of which are also required for myoblast fusion. These findings suggest that ANTS functions as an intracellular adaptor protein that relays signals from Dumbfounded to the cytoskeleton during myoblast fusion.
journal_name
Dev Celljournal_title
Developmental cellauthors
Chen EH,Olson ENdoi
10.1016/s1534-5807(01)00084-3keywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
705-15issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(01)00084-3journal_volume
1pub_type
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