Abstract：
:Signaling circuits often coordinate cellular membranes and actin filaments at distinct sites to direct cell behavior. In this issue of Developmental Cell, Bershteyn et al. outline how the molecular scaffold protein, MIM, which bends membranes and binds actin filaments, is at the middle of one such circuit to regulate ciliogenesis.
journal_name
Dev Celljournal_title
Developmental cellauthors
Kozminski KG,Schafer DAdoi
10.1016/j.devcel.2010.07.021subject
Has Abstractpub_date
2010-08-17 00:00:00pages
189-90issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(10)00349-7journal_volume
19pub_type
评论,杂志文章abstract：:Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.11.016
更新日期：2006-02-01 00:00:00
abstract：:Vertebrate gastrulation requires coordination of mesoderm specification with morphogenetic movements. While both of these processes require FGF signaling, it is not known how mesoderm specification and cell movements are coordinated during gastrulation. The related Sprouty and Spred protein families are recently disco...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.02.011
更新日期：2005-05-01 00:00:00
abstract：:In the field of breast biology, there is a growing appreciation for the "gatekeeping function" of basal cells during development and disease processes yet mechanisms regulating the generation of these cells are poorly understood. Here, we report that the proliferation of basal cells is controlled by SLIT/ROBO1 signali...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.05.012
更新日期：2011-06-14 00:00:00
abstract：:RhoA stimulates cell contractility by recruiting downstream effectors to the cortical plasma membrane. We now show that direct binding by anillin is required for effective signaling: this antagonizes the otherwise labile membrane association of GTP-RhoA to promote effector recruitment. However, since its binding to Rh...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.04.031
更新日期：2019-06-17 00:00:00
abstract：:Numerous signals drive the proliferative expansion of the distal endoderm and the underlying mesenchyme during lung branching morphogenesis, but little is known about how these signals are integrated. Here, we show by analysis of conditional double mutants that the two T-box transcription factor genes Tbx2 and Tbx3 ac...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.08.007
更新日期：2016-10-24 00:00:00
abstract：:Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H₂O₂)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly w...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.12.007
更新日期：2011-02-15 00:00:00
abstract：:Many promoters in eukaryotes have nucleosome-depleted regions (NDRs) containing transcription factor binding sites. However, the functional significance of NDRs is not well understood. Here, we examine NDR function in two cell cycle-regulated promoters, CLN2pr and HOpr, by varying nucleosomal coverage of the binding s...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.02.007
更新日期：2010-04-20 00:00:00
abstract：:p120-catenin is an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. Despite recent advances in understanding the roles that p120-catenin and Kaiso play in downstream modulation of Wnt/beta-catenin signaling, the identity of t...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.09.022
更新日期：2006-11-01 00:00:00
abstract：:How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migr...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2021.01.002
更新日期：2021-01-25 00:00:00
abstract：:By functioning as an enzyme cofactor, hemoglobin component, and gene regulator, heme is vital for life. One mode of heme-regulated transcription involves amplifying the activity of GATA-1, a key determinant of erythrocyte differentiation. To discover biological consequences of the metal cofactor-transcription factor m...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.07.022
更新日期：2018-09-10 00:00:00
abstract：:Cell and organelle membranes consist of a complex mixture of phospholipids (PLs) that determine their size, shape, and function. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes, yet how cells sense and regulate its levels in vivo remains unclear. Here we show that PCYT1A, the rate-li...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.04.012
更新日期：2018-05-21 00:00:00
abstract：:Infectious, self-propagating protein aggregates (prions) as well as structurally related amyloid fibrils have traditionally been associated with neurodegenerative diseases in mammals. However, recent work in fungi indicates that prions are not simply aberrations of protein folding, but are in fact widespread, conserve...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/s1534-5807(02)00118-1
更新日期：2002-02-01 00:00:00
abstract：:Autophagy is the major cellular process responsible for bulk cytoplasmic degradation. Two reports in this issue of Developmental Cell describe how both PI3 kinase and TOR signaling in Drosophila are critical for controlling autophagy in response to developmental and environmental cues. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2004.07.014
更新日期：2004-08-01 00:00:00
abstract：:Integrin expression and activity have been strongly correlated with developmental and pathological processes involving cell invasion through basement membranes. The role of integrins in mediating these invasions, however, remains unclear. Utilizing the genetically and visually accessible model of anchor cell (AC) inva...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.06.006
更新日期：2009-08-01 00:00:00
abstract：:The vertebral column derives from somites generated by segmentation of presomitic mesoderm (PSM). Somitogenesis involves a molecular oscillator, the segmentation clock, controlling periodic Notch signaling in the PSM. Here, we establish a novel link between Wnt/beta-catenin signaling and the segmentation clock. Axin2,...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00055-8
更新日期：2003-03-01 00:00:00
abstract：:Connecting phosphorylation events to kinases and phosphatases is key to understanding the molecular organization and signaling dynamics of networks. We have generated a validated set of transgenic RNA-interference reagents for knockdown and characterization of all protein kinases and phosphatases present during early ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.07.027
更新日期：2014-10-13 00:00:00
abstract：:Oxysterol binding protein-related proteins (ORPs) are conserved lipid binding polypeptides, enriched at ER contacts sites. ORPs promote non-vesicular lipid transport and work as lipid sensors in the context of many cellular tasks, but the determinants of their distinct localization and function are not understood. Her...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.10.031
更新日期：2017-12-04 00:00:00
abstract：:TORC1 is arguably the best-studied regulator of cellular growth in eukaryotes. However, its activity has not been assessed in vivo in developing multicellular organisms. Two studies in this issue of Developmental Cell (Kim et al., 2017; Romero-Pozuelo et al., 2017) surprisingly reveal a patchy, cell-cycle-controlled p...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2017.08.007
更新日期：2017-08-21 00:00:00
abstract：:The faithful alignment of homologous chromosomes during meiotic prophase requires the coordination of DNA double-strand break (DSB) repair with large-scale chromosome reorganization. Here we identify the phosphatase PP4 (Pph3/Psy2) as a mediator of this process in Saccharomyces cerevisiae. In pp4 mutants, early stages...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.09.006
更新日期：2010-10-19 00:00:00
abstract：:Phase separation represents an important form of subcellular compartmentalization. However, relatively little is known about how the formation or disassembly of such compartments is regulated. In zebrafish, the Balbiani body (Bb) and the germ plasm (Gp) are intimately linked phase-separated structures essential for ge...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.07.009
更新日期：2018-08-06 00:00:00
abstract：:RITS (RNA-induced initiation of transcriptional gene silencing complex) plays diverse roles in heterochromatin regulation: silencing transcription by recruitment of chromatin modifiers and destroying transcripts by RNAi. In a recent issue of Molecular Cell, Li et al. now show that the polymerization of Tas3, a compone...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.05.002
更新日期：2009-05-01 00:00:00
abstract：:Neurite fasciculation through contact-dependent signaling is important for the wiring and function of the neuronal circuits. Here, we describe a type of axon-dendrite fasciculation in C. elegans, where proximal dendrites of the nociceptor PVD adhere to the axon of the ALA interneuron. This axon-dendrite fasciculation ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.10.028
更新日期：2019-01-28 00:00:00
abstract：:Human centromeres are defined by alpha satellite DNA arrays that are distinct and chromosome specific. Most human chromosomes contain multiple alpha satellite arrays that are competent for centromere assembly. Here, we show that human centromeres are defined by chromosome-specific RNAs linked to underlying organizatio...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.07.001
更新日期：2017-08-07 00:00:00
abstract：:Reconstructing the lineage of cells is central to understanding development and is now also an important issue in stem cell research. Technological advances in genetically engineered permanent cell labeling, together with a multiplicity of fluorescent markers and sophisticated imaging, open new possibilities for prosp...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.07.019
更新日期：2011-09-13 00:00:00
abstract：:The protein kinase Aurora-A orchestrates key aspects of cell division, but its regulation has remained a major puzzle. That puzzle is now one step closer to being solved thanks to a recent paper by Zhao et al. appearing in the October 28(th) issue of Molecular Cell. In this work, the authors show that p21-activated ki...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2005.10.005
更新日期：2005-11-01 00:00:00
abstract：:In a recent issue of Molecular Cell, Cairo et al. (2013) report that the spindle checkpoint protein Mad1 shuttles between unattached kinetochores and nuclear pores. Mobile Mad1 inhibits the import receptor Kap121p, thus indirectly changing spindle dynamics. This adds nuclear transport control to the mitotic roles of M...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2013.01.003
更新日期：2013-01-28 00:00:00
abstract：:Tetrapod limbs display a great variety of forms and functions. In an attempt to understand factors influencing this diversity, Cretekos and colleagues, in a recent issue of Genes & Development, provide molecular insight into the evolution of wing morphology in bats. ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.01.011
更新日期：2008-02-01 00:00:00
abstract：:Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here, we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacial development. Str...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.02.006
更新日期：2015-04-06 00:00:00
abstract：:When two colonies of the tunicate Botryllus contact each other, they either fuse into a single colony or mount a destructive reaction, which keeps them apart. Which of the two reactions takes place is determined by a single, highly polymorphic fusion/histocompatibility (FuHC) locus. Recent communications report the cl...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.12.009
更新日期：2006-01-01 00:00:00
abstract：:The majority of excitatory synaptic transmission in the brain occurs at dendritic spines, which are actin-rich protrusions on the dendrites. The asymmetric nature of these structures suggests that proteins regulating cell polarity might be involved in their formation. Indeed, the polarity protein PAR-3 is required for...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.11.020
更新日期：2008-02-01 00:00:00
