Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis.

Abstract:

:The ability of the death ligand TRAIL to induce tumor cell apoptosis has led to the development of TRAIL-based cancer therapies. Reporting recently in Molecular Cell, Lu et al. (2014) show that the basis for differential TRAIL responses involves clustering of death receptor complexes by E-cadherin and the actin cytoskeleton.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Gallegos LL,Brugge JS

doi

10.1016/j.devcel.2014.06.031

subject

Has Abstract

pub_date

2014-07-14 00:00:00

pages

3-4

issue

1

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(14)00420-1

journal_volume

30

pub_type

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