Abstract：
:The ability of the death ligand TRAIL to induce tumor cell apoptosis has led to the development of TRAIL-based cancer therapies. Reporting recently in Molecular Cell, Lu et al. (2014) show that the basis for differential TRAIL responses involves clustering of death receptor complexes by E-cadherin and the actin cytoskeleton.
journal_name
Dev Celljournal_title
Developmental cellauthors
Gallegos LL,Brugge JSdoi
10.1016/j.devcel.2014.06.031subject
Has Abstractpub_date
2014-07-14 00:00:00pages
3-4issue
1eissn
1534-5807issn
1878-1551pii
S1534-5807(14)00420-1journal_volume
30pub_type
评论,杂志文章abstract：:The development of multicellular organisms requires the precisely coordinated regulation of an evolutionarily conserved group of signaling pathways. Temporal and spatial control of these signaling cascades is achieved through networks of regulatory proteins, segregation of pathway components in specific subcellular co...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.07.016
更新日期：2015-09-28 00:00:00
abstract：:Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al.(2007) present evidence to indicate that Chk1 als...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2007.01.005
更新日期：2007-02-01 00:00:00
abstract：:Airway smooth muscle is best known for its role as an airway constrictor in diseases such as asthma. However, its function in lung development is debated. A prevalent model, supported by in vitro data, posits that airway smooth muscle promotes lung branching through peristalsis and pushing intraluminal fluid to branch...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.02.001
更新日期：2020-04-06 00:00:00
abstract：:Optimal cell performance depends on cell size and the appropriate relative size, i.e., scaling, of the nucleus. How nuclear scaling is regulated and contributes to cell function is poorly understood, especially in skeletal muscle fibers, which are among the largest cells, containing hundreds of nuclei. Here, we presen...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.02.020
更新日期：2019-04-08 00:00:00
abstract：:The adaptor complex AP-2 plays an important role in cargo selection and clathrin lattice formation during clathrin-mediated endocytosis. In a recent issue of Molecular Cell, Honing et al. demonstrate that high-affinity AP-2 membrane association is achieved through a combination of low-affinity interactions with membra...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.05.013
更新日期：2005-06-01 00:00:00
abstract：:Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characterization of the facto...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.10.015
更新日期：2016-12-05 00:00:00
abstract：:Numerous signals drive the proliferative expansion of the distal endoderm and the underlying mesenchyme during lung branching morphogenesis, but little is known about how these signals are integrated. Here, we show by analysis of conditional double mutants that the two T-box transcription factor genes Tbx2 and Tbx3 ac...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.08.007
更新日期：2016-10-24 00:00:00
abstract：:How kinetochores regulate microtubule dynamics to ensure proper kinetochore-microtubule interactions is unknown. Here, we studied this during early mitosis in Saccharomyces cerevisiae. When a microtubule shrinks and its plus end reaches a kinetochore bound to its lateral surface, the microtubule end attempts to tether...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.09.006
更新日期：2011-11-15 00:00:00
abstract：:Regulating cell proliferation and differentiation in CNS development requires both extraordinary complexity and precision. Neural progenitors receive graded overlapping signals from midline signaling centers, yet each makes a unique cell fate decision in a spatiotemporally restricted pattern. The Nde1-Lis1 complex reg...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.04.006
更新日期：2013-05-13 00:00:00
abstract：:RITS (RNA-induced initiation of transcriptional gene silencing complex) plays diverse roles in heterochromatin regulation: silencing transcription by recruitment of chromatin modifiers and destroying transcripts by RNAi. In a recent issue of Molecular Cell, Li et al. now show that the polymerization of Tas3, a compone...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.05.002
更新日期：2009-05-01 00:00:00
abstract：:The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2016.04.019
更新日期：2016-05-23 00:00:00
abstract：:Boundary formation and epithelialization are crucial processes in the morphological segmentation of vertebrate somites. By a genetic screening procedure with zebrafish, we identified two genes, integrinalpha5 (itga5) and fibronectin (fn), required for these processes. Fibronectin proteins accumulate at somite boundari...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.03.006
更新日期：2005-04-01 00:00:00
abstract：:Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.01.005
更新日期：2008-03-01 00:00:00
abstract：:Mammalian neurulation is completed when the dorsolateral neural folds bend inwards, their tips make adhesive contacts across the midline, and the epithelia remodel to create a closed neural tube. Two recent papers (one by Camerer et al. in this issue of Developmental Cell) demonstrate a vital role for protease-activat...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2010.01.002
更新日期：2010-01-19 00:00:00
abstract：:Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging. Here, we developed an optimized protocol for single-molecule transcript imaging in the intact pancreas and used it to identify a sub-po...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.11.001
更新日期：2019-01-07 00:00:00
abstract：:It has recently been reported that a common side effect of translation-blocking morpholino antisense oligonucleotides is the induction of a set of innate immune response genes in Xenopus embryos and that splicing-blocking morpholinos lead to unexpected off-target mis-splicing events. Here, we present an analysis of al...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2019.04.019
更新日期：2019-05-20 00:00:00
abstract：:Hearts of mice lacking Isl1, a LIM homeodomain transcription factor, are completely missing the outflow tract, right ventricle, and much of the atria. isl1 expression and lineage tracing of isl1-expressing progenitors demonstrate that Isl1 is a marker for a distinct population of undifferentiated cardiac progenitors t...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00363-0
更新日期：2003-12-01 00:00:00
abstract：:In vertebrates, the microtubule binding protein TPX2 is required for meiotic and mitotic spindle assembly. TPX2 is also known to bind to and activate Aurora A kinase and target it to the spindle. However, the relationship between the TPX2-Aurora A interaction and the role of TPX2 in spindle assembly is unclear. Here, ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.07.002
更新日期：2005-08-01 00:00:00
abstract：:Selection of the correct targets for myelination and regulation of myelin sheath growth are essential for central nervous system (CNS) formation and function. Through a genetic screen in zebrafish and complementary analyses in mice, we find that loss of oligodendrocyte Neurofascin leads to mistargeting of myelin to ce...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.10.016
更新日期：2019-12-16 00:00:00
abstract：:During organogenesis, coherent organ growth arises from spatiotemporally coordinated decisions of individual cells. In the root of Arabidopsis thaliana, this coordination results in the establishment of a division and a differentiation zone. Cells continuously move through these zones; thus, a major question is how th...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.04.004
更新日期：2020-05-18 00:00:00
abstract：:Lymphatic vessels are essential for tissue homeostasis and immune surveillance and contribute to pathological conditions. Lymphatic endothelium differentiates from veins and forms an independent vascular tree with only few connections to the venous circulation. Failure of blood and lymphatic vessel separation results ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.01.009
更新日期：2010-03-16 00:00:00
abstract：:Major histocompatibility complex class Ib molecules may play a surprising role in pheromone detection in mammals. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章,评审
doi：10.1016/s1534-5807(03)00066-2
更新日期：2003-03-01 00:00:00
abstract：:Directional cell migration is critical for metazoan development. We define two molecular pathways that activate the Arp2/3 complex during neuroblast migration in Caenorhabditis elegans. The transmembrane protein MIG-13/Lrp12 is linked to the Arp2/3 nucleation-promoting factors WAVE or WASP through direct interactions ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.09.029
更新日期：2016-10-24 00:00:00
abstract：:Recent data indicate that cystic fibrosis (CF) airway mucus is anaerobic. This suggests that Pseudomonas aeruginosa infection in CF reflects biofilm formation and persistence in an anaerobic environment. P. aeruginosa formed robust anaerobic biofilms, the viability of which requires rhl quorum sensing and nitric oxide...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00295-2
更新日期：2002-10-01 00:00:00
abstract：:Cells commit to mitosis by abruptly activating the mitotic cyclin-Cdk complexes. During Drosophila gastrulation, mitosis is associated with the transcriptional activation of cdc25(string), a phosphatase that activates Cdk1. Here, we demonstrate that the switch-like entry into mitosis observed in the Drosophila embryo ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.01.019
更新日期：2012-04-17 00:00:00
abstract：:Alzheimer's disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that "designer" molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligo...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.03.009
更新日期：2015-03-23 00:00:00
abstract：:Bazooka/Par-3 (Baz) is a key regulator of cell polarity in epithelial cells and neuroblasts (NBs). Phosphorylation of Baz by PAR-1 and aPKC is required for its function in epithelia, but little is known about the dephosphorylation mechanisms that antagonize the activities of these kinases or about the relevance of Baz...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.04.011
更新日期：2009-06-01 00:00:00
abstract：:Determination of left-right asymmetry in mouse embryos is established by a leftward fluid flow that is generated by clockwise rotation of node cilia. How node cilia achieve stable unidirectional rotation has remained unknown, however. Here we show that brief exposure to the microtubule-stabilizing drug paclitaxel (Tax...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.10.001
更新日期：2015-10-26 00:00:00
abstract：:Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway. A dominant mutation bzr1-...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00153-3
更新日期：2002-04-01 00:00:00
abstract：:Presenilins are components of the gamma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch proteins. A C. elegans genetic screen revealed two genes, aph-1 and pen-2, encoding multipass transmembrane proteins, that interact strongly with sel-12/presenilin and aph-2/nicastrin. Human ap...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00189-2
更新日期：2002-07-01 00:00:00
