Abstract:
:The dorsoventral axis of the Drosophila embryo is patterned by a gradient of bone morphogenetic protein (BMP) ligands. In a process requiring at least three additional extracellular proteins, a broad domain of weak signaling forms and then abruptly sharpens into a narrow dorsal midline peak. Using experimental and computational approaches, we investigate how the interactions of a multiprotein network create the unusual shape and dynamics of formation of this gradient. Starting from observations suggesting that receptor-mediated BMP degradation is an important driving force in gradient dynamics, we develop a general model that is capable of capturing both subtle aspects of gradient behavior and a level of robustness that agrees with in vivo results.
journal_name
Dev Celljournal_title
Developmental cellauthors
Mizutani CM,Nie Q,Wan FY,Zhang YT,Vilmos P,Sousa-Neves R,Bier E,Marsh JL,Lander ADdoi
10.1016/j.devcel.2005.04.009keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
915-24issue
6eissn
1534-5807issn
1878-1551pii
S1534-5807(05)00140-1journal_volume
8pub_type
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