Formation of the BMP activity gradient in the Drosophila embryo.

Abstract:

:The dorsoventral axis of the Drosophila embryo is patterned by a gradient of bone morphogenetic protein (BMP) ligands. In a process requiring at least three additional extracellular proteins, a broad domain of weak signaling forms and then abruptly sharpens into a narrow dorsal midline peak. Using experimental and computational approaches, we investigate how the interactions of a multiprotein network create the unusual shape and dynamics of formation of this gradient. Starting from observations suggesting that receptor-mediated BMP degradation is an important driving force in gradient dynamics, we develop a general model that is capable of capturing both subtle aspects of gradient behavior and a level of robustness that agrees with in vivo results.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Mizutani CM,Nie Q,Wan FY,Zhang YT,Vilmos P,Sousa-Neves R,Bier E,Marsh JL,Lander AD

doi

10.1016/j.devcel.2005.04.009

keywords:

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

915-24

issue

6

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(05)00140-1

journal_volume

8

pub_type

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