Model organisms as a guide to mammalian aging.

abstract：:Understanding the mechanisms driving tissue and organ formation requires knowledge across scales. How do signaling pathways specify distinct tissue types? How does the patterning system control morphogenesis? How do these processes evolve? The Drosophila egg chamber, where EGF and BMP signaling intersect to specify un...

journal_title：Developmental cell

authors： Osterfield M,Berg CA,Shvartsman SY

更新日期：2017-05-22 00:00:00

abstract：:How metabolism is rewired during embryonic development is still largely unknown, as it remains a major technical challenge to resolve metabolic activities or metabolite levels with spatiotemporal resolution. Here, we investigated metabolic changes during development of organogenesis-stage mouse embryos, focusing on th...

journal_title：Developmental cell

authors： Bulusu V,Prior N,Snaebjornsson MT,Kuehne A,Sonnen KF,Kress J,Stein F,Schultz C,Sauer U,Aulehla A

更新日期：2017-02-27 00:00:00

abstract：:Reactive oxygen species (ROS) such as hydrogen peroxide are generated at wound sites and act as long-range signals in wound healing. The roles of other ROS in wound repair are little explored. Here, we reveal a cytoprotective role for mitochondrial ROS (mtROS) in Caenorhabditis elegans skin wound healing. We show that...

journal_title：Developmental cell

authors： Xu S,Chisholm AD

更新日期：2014-10-13 00:00:00

abstract：:The Frizzled (Fz) receptor is required cell autonomously in Wnt/beta-catenin and planar cell polarity (PCP) signaling. In addition to these requirements, Fz acts nonautonomously during PCP establishment: wild-type cells surrounding fz(-) patches reorient toward the fz(-) cells. The molecular mechanism(s) of nonautonom...

journal_title：Developmental cell

authors： Wu J,Mlodzik M

更新日期：2008-09-01 00:00:00

abstract：:Axon guidance at the Drosophila midline relies on dynamic regulation of the guidance receptor Robo by its negative regulator Comm. Recent findings demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo signaling by promoting the sorting of Robo into the endocytic pathway. ...

journal_title：Developmental cell

authors： Rosenzweig M,Garrity P

更新日期：2002-09-01 00:00:00

abstract：:Epithelial reorganization involves coordinated changes in cell shapes and movements. This restructuring occurs during formation of placodes, ectodermal thickenings that initiate the morphogenesis of epithelial organs including hair, mammary gland, and tooth. Signaling pathways in ectodermal placode formation are well ...

journal_title：Developmental cell

authors： Ahtiainen L,Lefebvre S,Lindfors PH,Renvoisé E,Shirokova V,Vartiainen MK,Thesleff I,Mikkola ML

更新日期：2014-03-10 00:00:00

abstract：:The biogenesis of lipid droplets (LDs) and the development of adipocytes are two key aspects of mammalian fat storage. SEIPIN, an integral membrane protein of the endoplasmic reticulum (ER), plays a critical role in both LD formation and adipogenesis. The molecular function of SEIPIN, however, has yet to be elucidated...

journal_title：Developmental cell

authors： Yan R,Qian H,Lukmantara I,Gao M,Du X,Yan N,Yang H

更新日期：2018-10-22 00:00:00

abstract：:Morphological plasticity and front-rear polarity are essential for directed cell migration. In this issue of Developmental Cell, Witze et al. (2013) demonstrate that Wnt5a-mediated signaling induces localization of the cortical endoplasmic reticulum to the trailing edge of melanoma cells and mediates calcium flux, rea...

journal_title：Developmental cell

authors： Mladinich KM,Huttenlocher A

更新日期：2013-09-30 00:00:00

abstract：:In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targetin...

journal_title：Developmental cell

authors： Kim DH,Park MJ,Gwon GH,Silkov A,Xu ZY,Yang EC,Song S,Song K,Kim Y,Yoon HS,Honig B,Cho W,Cho Y,Hwang I

更新日期：2014-09-08 00:00:00

abstract：:Spindle checkpoint silencing is crucial for cell-cycle progression, but mechanisms underlying this process remain mysterious. Two papers, one in this issue of Developmental Cell (Meadows et al., 2011) and one in Current Biology (Rosenberg et al., 2011), begin to show how phosphatase PP1-gamma connects chromosome-micro...

journal_title：Developmental cell

authors： Maldonado M,Kapoor TM

更新日期：2011-06-14 00:00:00

abstract：:Dynamin family members are large GTPases that assemble into multimeric spirals. These spirals promote membrane fission or fusion, or they inhibit processes such as viral replication. Two new studies by Chappie et al. and Gao et al. in a recent issue of Nature identify interactions between subunits of dynamin spirals, ...

journal_title：Developmental cell

authors： van der Bliek AM,Payne GS

更新日期：2010-05-18 00:00:00

abstract：:Asymmetric cell division--where two dissimilar daughter cells are produced--relies on asymmetric positioning of the telophase spindle midzone, which specifies the cleavage furrow. Ou et al. (2010) now report in Science a mechanism of asymmetric midzone positioning driven by a polarized cortical distribution of the con...

journal_title：Developmental cell

authors： Li R

更新日期：2010-11-16 00:00:00

abstract：:Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures defined as regions of the ER that tightly associate with the plasma membrane. However, little is known about the mechanisms that tether these organelles together and why such connections are maintained. Using a quantitative proteomic appr...

journal_title：Developmental cell

authors： Manford AG,Stefan CJ,Yuan HL,Macgurn JA,Emr SD

更新日期：2012-12-11 00:00:00

abstract：:When two colonies of the tunicate Botryllus contact each other, they either fuse into a single colony or mount a destructive reaction, which keeps them apart. Which of the two reactions takes place is determined by a single, highly polymorphic fusion/histocompatibility (FuHC) locus. Recent communications report the cl...

journal_title：Developmental cell

authors： Klein J

更新日期：2006-01-01 00:00:00

abstract：:Many patterns of cell and tissue organization are specified during development by gradients of morphogens, substances that assign different cell fates at different concentrations. Gradients form by morphogen transport from a localized site, but whether this occurs by simple diffusion or by more elaborate mechanisms is...

journal_title：Developmental cell

authors： Lander AD,Nie Q,Wan FY

更新日期：2002-06-01 00:00:00

abstract：:Signaling circuits often coordinate cellular membranes and actin filaments at distinct sites to direct cell behavior. In this issue of Developmental Cell, Bershteyn et al. outline how the molecular scaffold protein, MIM, which bends membranes and binds actin filaments, is at the middle of one such circuit to regulate ...

journal_title：Developmental cell

authors： Kozminski KG,Schafer DA

更新日期：2010-08-17 00:00:00

abstract：:Local translation allows spatial control of gene expression. Here, we performed a dual protein-mRNA localization screen, using smFISH on 523 human cell lines expressing GFP-tagged genes. 32 mRNAs displayed specific cytoplasmic localizations with local translation at unexpected locations, including cytoplasmic protrusi...

journal_title：Developmental cell

authors： Chouaib R,Safieddine A,Pichon X,Imbert A,Kwon OS,Samacoits A,Traboulsi AM,Robert MC,Tsanov N,Coleno E,Poser I,Zimmer C,Hyman A,Le Hir H,Zibara K,Peter M,Mueller F,Walter T,Bertrand E

更新日期：2020-09-28 00:00:00

abstract：:Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here...

journal_title：Developmental cell

authors： Bordt EA,Clerc P,Roelofs BA,Saladino AJ,Tretter L,Adam-Vizi V,Cherok E,Khalil A,Yadava N,Ge SX,Francis TC,Kennedy NW,Picton LK,Kumar T,Uppuluri S,Miller AM,Itoh K,Karbowski M,Sesaki H,Hill RB,Polster BM

更新日期：2017-03-27 00:00:00

abstract：:Microtubules are normally organized at centrosomes, but other sites can also serve as microtubule organizing centers (MTOCs). In this issue of Developmental Cell, Procter et al. (2018) show that the human cytomegalovirus virion assembly compartment acts as a dynamic Golgi-derived MTOC where EB3 nucleates microtubules ...

journal_title：Developmental cell

authors： Lyon SM,Kalejta RF

更新日期：2018-04-09 00:00:00

abstract：:Little is known about the mechanisms governing neonatal growth and maturation of organs. Here we demonstrate that calcineurin/Nuclear Factor of Activated T cells (Cn/NFAT) signaling regulates neonatal pancreatic development in mouse and human islets. Inactivation of calcineurin b1 (Cnb1) in mouse islets impaired dense...

journal_title：Developmental cell

authors： Goodyer WR,Gu X,Liu Y,Bottino R,Crabtree GR,Kim SK

更新日期：2012-07-17 00:00:00

abstract：:COPII vesicles assemble at ER subdomains called transitional ER (tER) sites, but the mechanism that generates tER sites is unknown. To study tER biogenesis, we analyzed the transmembrane protein Sec12, which initiates COPII vesicle formation. Sec12 is concentrated at discrete tER sites in the budding yeast Pichia past...

journal_title：Developmental cell

authors： Soderholm J,Bhattacharyya D,Strongin D,Markovitz V,Connerly PL,Reinke CA,Glick BS

更新日期：2004-05-01 00:00:00

abstract：:CPEB is a sequence-specific RNA binding protein that regulates translation during vertebrate oocyte maturation. Adult female CPEB knockout mice contained vestigial ovaries that were devoid of oocytes; ovaries from mid-gestation embryos contained oocytes that were arrested at the pachytene stage. Male CPEB null mice al...

journal_title：Developmental cell

authors： Tay J,Richter JD

更新日期：2001-08-01 00:00:00

abstract：:Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types. This is especially critical during embryogenesis, when extensive cell proliferation, patterning, and migration events take place. Here we show that vertebrate primordial germ cells (PGCs) are pr...

journal_title：Developmental cell

authors： Gross-Thebing T,Yigit S,Pfeiffer J,Reichman-Fried M,Bandemer J,Ruckert C,Rathmer C,Goudarzi M,Stehling M,Tarbashevich K,Seggewiss J,Raz E

更新日期：2017-12-18 00:00:00

abstract：:PTEN is one of the most commonly lost tumor suppressors in human cancer and is known to inhibit insulin signaling. Eph receptor tyrosine kinases (RTKs) have also been implicated in cancer formation and progression, and they have diverse functions, including nervous and vascular system development. We show that in C. e...

journal_title：Developmental cell

authors： Brisbin S,Liu J,Boudreau J,Peng J,Evangelista M,Chin-Sang I

更新日期：2009-10-01 00:00:00

abstract：:Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we ...

journal_title：Developmental cell

authors： Centanin L,Dekanty A,Romero N,Irisarri M,Gorr TA,Wappner P

更新日期：2008-04-01 00:00:00

abstract：:Septins are polymerizing GTP binding proteins required for cortical organization during cytokinesis and other cellular processes. A mammalian septin gene Sept4 is expressed mainly in postmitotic neural cells and postmeiotic male germ cells. In mouse and human spermatozoa, SEPT4 and other septins are found in the annul...

journal_title：Developmental cell

authors： Ihara M,Kinoshita A,Yamada S,Tanaka H,Tanigaki A,Kitano A,Goto M,Okubo K,Nishiyama H,Ogawa O,Takahashi C,Itohara S,Nishimune Y,Noda M,Kinoshita M

更新日期：2005-03-01 00:00:00

abstract：:Chronic inflammation is associated with tumorigenesis, but how acute inflammation affects the tumor microenvironment is less known. Recently, Antonio et al. (2015) found that neutrophils attracted to an acute wound such as a biopsy drive cell proliferation of nearby pre-neoplastic cells, suggesting that acute wounds m...

journal_title：Developmental cell

authors： Rosowski EE,Huttenlocher A

更新日期：2015-07-27 00:00:00

abstract：:p120-catenin is an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. Despite recent advances in understanding the roles that p120-catenin and Kaiso play in downstream modulation of Wnt/beta-catenin signaling, the identity of t...

journal_title：Developmental cell

authors： Park JI,Ji H,Jun S,Gu D,Hikasa H,Li L,Sokol SY,McCrea PD

更新日期：2006-11-01 00:00:00

abstract：:Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to si...

journal_title：Developmental cell

authors： Graml V,Studera X,Lawson JLD,Chessel A,Geymonat M,Bortfeld-Miller M,Walter T,Wagstaff L,Piddini E,Carazo Salas RE

更新日期：2014-10-27 00:00:00

abstract：:Neuroblastomas are associated with KIF1Bβ mutations within tumor suppressor region 1p36. In this issue of Developmental Cell, Li et al. (2016) show that KIF1Bβ binding releases calcineurin autoinhibition, leading to dephosphorylation of the DRP1 GTPase and subsequent mitochondrial fragmentation. KIF1Bβ impairment caus...

journal_title：Developmental cell

authors： Blackstone C

更新日期：2016-01-25 00:00:00