C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair.

abstract：:NAD(H)-binding proteins play important roles in cell-cycle and developmental signaling in eukaryotes. We identified a bifunctional NAD(H)-binding regulator (KidO) that integrates cell-fate signaling with cytokinesis in the bacterium Caulobacter crescentus. KidO stimulates the DivJ kinase and directly acts on the cytok...

journal_title：Developmental cell

authors： Radhakrishnan SK,Pritchard S,Viollier PH

更新日期：2010-01-19 00:00:00

abstract：:Determination of left-right asymmetry in mouse embryos is established by a leftward fluid flow that is generated by clockwise rotation of node cilia. How node cilia achieve stable unidirectional rotation has remained unknown, however. Here we show that brief exposure to the microtubule-stabilizing drug paclitaxel (Tax...

journal_title：Developmental cell

authors： Shinohara K,Chen D,Nishida T,Misaki K,Yonemura S,Hamada H

更新日期：2015-10-26 00:00:00

abstract：:Changes in the genetic makeup of an organism can extend lifespan significantly if they promote tolerance to environmental insults and thus prevent the general deterioration of cellular function that is associated with aging. Here, we introduce the Jun N-terminal kinase (JNK) signaling pathway as a genetic determinant ...

journal_title：Developmental cell

authors： Wang MC,Bohmann D,Jasper H

更新日期：2003-11-01 00:00:00

abstract：:The mechanism responsible for subdividing the embryo into individual tissues is a fundamental, yet still poorly understood, question in developmental biology. Various general hypotheses have been proposed, involving differences in cell adhesion, contractility, or contact-mediated repulsion. However, the key parameter ...

journal_title：Developmental cell

authors： Fagotto F,Rohani N,Touret AS,Li R

更新日期：2013-10-14 00:00:00

abstract：:Several genes have been implicated in heart tube formation, yet we know little about underlying cellular mechanisms. We analyzed the cellular architecture of the migrating myocardial precursors, and find that they form coherent epithelia that mature as they move medially. Mutant analyses indicate that the cardia bifid...

journal_title：Developmental cell

authors： Trinh LA,Stainier DY

更新日期：2004-03-01 00:00:00

abstract：:In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes an...

journal_title：Developmental cell

authors： Karsenty G,Wagner EF

更新日期：2002-04-01 00:00:00

abstract：:During organogenesis, coherent organ growth arises from spatiotemporally coordinated decisions of individual cells. In the root of Arabidopsis thaliana, this coordination results in the establishment of a division and a differentiation zone. Cells continuously move through these zones; thus, a major question is how th...

journal_title：Developmental cell

authors： Salvi E,Rutten JP,Di Mambro R,Polverari L,Licursi V,Negri R,Dello Ioio R,Sabatini S,Ten Tusscher K

更新日期：2020-05-18 00:00:00

abstract：:Polarized delivery of signaling and adhesion molecules to the leading edge is required for directional migration of cells. Here, we describe a role for the PIP(2)-synthesizing enzyme, PIPKIγi2, in regulation of exocyst complex control of cell polarity and polarized integrin trafficking during migration. Loss of PIPKIγ...

journal_title：Developmental cell

authors： Thapa N,Sun Y,Schramp M,Choi S,Ling K,Anderson RA

更新日期：2012-01-17 00:00:00

abstract：:All complex multicellular organisms must solve the problem of generating diverse and appropriately patterned cell types. Asymmetric division, in which a single mother cell gives rise to daughters with distinct identities, is instrumental in the generation of cellular diversity and higher-level patterns. In animal syst...

journal_title：Developmental cell

authors： Abrash EB,Bergmann DC

更新日期：2009-06-01 00:00:00

abstract：:Accurate chromosome segregation in mitosis and meiosis requires that the cohesin complex be protected at the centromere by the Shugoshin/MEI-S332 protein family. Recent studies show that Sgo directly binds the phosphatase PP2A, tethering it to the centromere where it can protect cohesin subunits from phosphorylation, ...

journal_title：Developmental cell

authors： Clarke A,Orr-Weaver TL

更新日期：2006-05-01 00:00:00

abstract：:Pontin and reptin are conserved AAA+ ATPases identified in chromatin-remodeling complexes. In a recent issue of Cell, Venteicher et al. provide new insight into the function of pontin and reptin in telomerase biogenesis, which is important for cellular senescence, aging, and cancer. These unexpected findings have impl...

journal_title：Developmental cell

authors： Baek SH

更新日期：2008-04-01 00:00:00

abstract：:Intercellular communication is vital to tumor progression. In this issue of Developmental Cell, Bertolini et al. (2020) describe how small extracellular vesicles released from hypoxic mammary tumor cells facilitate intercellular communication, leading to alterations in mitochondrial dynamics and acquisition of invasiv...

journal_title：Developmental cell

authors： Boomgarden AC,Clancy JW,D'Souza-Schorey C

更新日期：2020-10-26 00:00:00

abstract：:The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell autonomously and nonautonomously. We demonstrate that these two activities of fz in planar polarity are temporally separable in both the eye and wing. The nonautonomous function is dishevelled (dsh...

journal_title：Developmental cell

authors： Strutt H,Strutt D

更新日期：2002-12-01 00:00:00

abstract：:Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essent...

journal_title：Developmental cell

authors： Miao R,Li M,Zhang Q,Yang C,Wang X

更新日期：2020-01-06 00:00:00

abstract：:Asymmetric cell division--where two dissimilar daughter cells are produced--relies on asymmetric positioning of the telophase spindle midzone, which specifies the cleavage furrow. Ou et al. (2010) now report in Science a mechanism of asymmetric midzone positioning driven by a polarized cortical distribution of the con...

journal_title：Developmental cell

authors： Li R

更新日期：2010-11-16 00:00:00

abstract：:Little is known about the mechanisms governing neonatal growth and maturation of organs. Here we demonstrate that calcineurin/Nuclear Factor of Activated T cells (Cn/NFAT) signaling regulates neonatal pancreatic development in mouse and human islets. Inactivation of calcineurin b1 (Cnb1) in mouse islets impaired dense...

journal_title：Developmental cell

authors： Goodyer WR,Gu X,Liu Y,Bottino R,Crabtree GR,Kim SK

更新日期：2012-07-17 00:00:00

abstract：:In response to cellular stress, mitochondria remodel their structure by organelle division and fusion. In this issue of Developmental Cell, Cooper et al. (2014) report that a nuclear protein, cyclin C, is recruited from nuclei to mitochondria upon oxidative stress and promotes mitochondrial division and apoptosis of t...

journal_title：Developmental cell

authors： Adachi Y,Sesaki H

更新日期：2014-01-27 00:00:00

abstract：:CLIPs are microtubule plus end-associated proteins that mediate interactions required for cell polarity and cell division. Here we demonstrate that budding yeast Bik1, unlike its human ortholog CLIP-170, is targeted to the microtubule plus end by a kinesin-dependent transport mechanism. Bik1 forms a complex with the k...

journal_title：Developmental cell

authors： Carvalho P,Gupta ML Jr,Hoyt MA,Pellman D

更新日期：2004-06-01 00:00:00

abstract：:Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al.(2007) present evidence to indicate that Chk1 als...

journal_title：Developmental cell

authors： Yu H

更新日期：2007-02-01 00:00:00

abstract：:Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players. ...

journal_title：Developmental cell

authors： Donaldson JG

更新日期：2003-10-01 00:00:00

abstract：:Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for either Tet1 or Tet2 are viable, raising the question of whether these enzymes have overlapping roles in development. Here we have generated Tet1 and Tet2 double-knockout (DKO)...

journal_title：Developmental cell

authors： Dawlaty MM,Breiling A,Le T,Raddatz G,Barrasa MI,Cheng AW,Gao Q,Powell BE,Li Z,Xu M,Faull KF,Lyko F,Jaenisch R

更新日期：2013-02-11 00:00:00

abstract：:In this issue of Developmental Cell, Schuster et al. (2014) describe the signals regulated by the bHLH transcription factor HEC1 during Arabidopsis stem cell maintenance. HEC1 acts antagonistically with other factors, integrating multiple cues to provide a balance between cellular differentiation and proliferation. ...

journal_title：Developmental cell

authors： Sparks EE,Benfey PN

更新日期：2014-02-24 00:00:00

abstract：:Apoptosis has been implicated in compensatory proliferation signaling (CPS), whereby dying cells induce proliferation in neighboring cells as a means to restore homeostasis. The nature of signaling between apoptotic cells and their neighboring cells remains largely unknown. Here we show that a fraction of apoptotic ce...

journal_title：Developmental cell

authors： Gupta KH,Goldufsky JW,Wood SJ,Tardi NJ,Moorthy GS,Gilbert DZ,Zayas JP,Hahm E,Altintas MM,Reiser J,Shafikhani SH

更新日期：2017-06-19 00:00:00

abstract：:The lymphatic system is crucial for fluid homeostasis, immune responses, and numerous pathological processes. However, the molecular mechanisms responsible for establishing the anatomical form of the lymphatic vascular network remain largely unknown. Here, we show that chemokine signaling provides critical guidance cu...

journal_title：Developmental cell

authors： Cha YR,Fujita M,Butler M,Isogai S,Kochhan E,Siekmann AF,Weinstein BM

更新日期：2012-04-17 00:00:00

abstract：:The actin remodeling factor N-WASP is best known as an Arp2/3 complex activator in processes like endocytosis, extracellular matrix degradation, and host-pathogen interaction. In this issue of Developmental Cell, Juin et al. establish a novel trafficking function for N-WASP in driving lysophosphatidic acid-dependent c...

journal_title：Developmental cell

authors： Rottner K,Schaks M

更新日期：2019-11-18 00:00:00

abstract：:The ability of cells to form and release multiple classes of extracellular vesicles (EVs) is an increasingly well-recognized phenomenon. EVs are best known as mediators of intercellular communication. However, in a recent issue of Nature, Keller et al. show that they function as decoys to mitigate bacterial toxins. ...

journal_title：Developmental cell

authors： Panizza E,Cerione RA,Antonyak MA

更新日期：2020-04-20 00:00:00

abstract：:Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue...

journal_title：Developmental cell

authors： Shimada Y,Yonemura S,Ohkura H,Strutt D,Uemura T

更新日期：2006-02-01 00:00:00

abstract：:Precise cell division control is critical for developmental patterning. For the differentiation of a functional stoma, a cellular valve for efficient gas exchange, the single symmetric division of an immediate precursor is absolutely essential. Yet, the mechanism governing this event remains unclear. Here we report co...

journal_title：Developmental cell

authors： Han SK,Qi X,Sugihara K,Dang JH,Endo TA,Miller KL,Kim ED,Miura T,Torii KU

更新日期：2018-05-07 00:00:00

abstract：:Recent studies have demonstrated that MyoD initiates a feed-forward regulation of skeletal muscle gene expression, predicting that MyoD binds directly to many genes expressed during differentiation. We have used chromatin immunoprecipitation and high-throughput sequencing to identify genome-wide binding of MyoD in sev...

journal_title：Developmental cell

authors： Cao Y,Yao Z,Sarkar D,Lawrence M,Sanchez GJ,Parker MH,MacQuarrie KL,Davison J,Morgan MT,Ruzzo WL,Gentleman RC,Tapscott SJ

更新日期：2010-04-20 00:00:00

abstract：:Wingless (Wg) is a morphogen required for the patterning of many Drosophila tissues. Several lines of evidence implicate heparan sulfate-modified proteoglycans (HSPGs) such as Dally-like protein (Dlp) in the control of Wg distribution and signaling. We show that dlp is required to limit Wg levels in the matrix, contra...

journal_title：Developmental cell

authors： Kirkpatrick CA,Dimitroff BD,Rawson JM,Selleck SB

更新日期：2004-10-01 00:00:00