A role for C. elegans Eph RTK signaling in PTEN regulation.

abstract：:The function of local protein synthesis in synaptic plasticity and its dysregulation in fragile X syndrome (FXS) is well studied, however the contribution of regulated mRNA transport to this function remains unclear. We report a function for the fragile X mental retardation protein (FMRP) in the rapid, activity-regula...

journal_title：Developmental cell

authors： Dictenberg JB,Swanger SA,Antar LN,Singer RH,Bassell GJ

更新日期：2008-06-01 00:00:00

abstract：:Formation of the embryonic heart tube requires the medial migration and merger of bilateral precursor populations. A new study of zebrafish cardiogenesis published in this issue of Developmental Cell indicates that precursor migration involves formation of a coherent epithelium and that fibronectin plays an important ...

journal_title：Developmental cell

authors： Glickman NS,Yelon D

更新日期：2004-03-01 00:00:00

abstract：:Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear. Here, we show that mice lacking Gadd45γ also exhibit XY gonadal sex reversal ca...

journal_title：Developmental cell

authors： Warr N,Carre GA,Siggers P,Faleato JV,Brixey R,Pope M,Bogani D,Childers M,Wells S,Scudamore CL,Tedesco M,del Barco Barrantes I,Nebreda AR,Trainor PA,Greenfield A

更新日期：2012-11-13 00:00:00

abstract：:Asymmetric cell divisions generate cellular diversity. In Drosophila, embryonic neuroblasts target cell fate determinants basally, rotate their spindles by 90 degrees to align with the apical-basal axis, and divide asymmetrically in a stem cell-like fashion. In this process, apically localized Bazooka recruits Inscute...

journal_title：Developmental cell

authors： Petritsch C,Tavosanis G,Turck CW,Jan LY,Jan YN

更新日期：2003-02-01 00:00:00

abstract：:The zona pellucida surrounding ovulated mouse eggs contains three glycoproteins, two of which (ZP2 and ZP3) are reported sperm receptors. After fertilization, the zona pellucida is modified ad minimus by cleavage of ZP2, and sperm no longer bind. Crosstaxa sperm binding is limited among mammals, and human sperm do not...

journal_title：Developmental cell

authors： Rankin TL,Coleman JS,Epifano O,Hoodbhoy T,Turner SG,Castle PE,Lee E,Gore-Langton R,Dean J

更新日期：2003-07-01 00:00:00

abstract：:During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell-cycle progression, and cytokinesis. Rac1 null cells migrate markedly less efficiently, but s...

journal_title：Developmental cell

authors： Li A,Ma Y,Yu X,Mort RL,Lindsay CR,Stevenson D,Strathdee D,Insall RH,Chernoff J,Snapper SB,Jackson IJ,Larue L,Sansom OJ,Machesky LM

更新日期：2011-10-18 00:00:00

abstract：:The cilia and cell cycles are inextricably linked. Centrioles in the basal body of cilia nucleate the ciliary axoneme and sequester pericentriolar matrix (PCM) at the centrosome to organize the mitotic spindle. Cilia themselves respond to growth signals, prompting cilia resorption and cell cycle re-entry. We describe ...

journal_title：Developmental cell

authors： Ford MJ,Yeyati PL,Mali GR,Keighren MA,Waddell SH,Mjoseng HK,Douglas AT,Hall EA,Sakaue-Sawano A,Miyawaki A,Meehan RR,Boulter L,Jackson IJ,Mill P,Mort RL

更新日期：2018-11-19 00:00:00

abstract：:The Par polarity complex creates mutually exclusive cortical domains in diverse animal cells. Activity of the atypical protein kinase C (aPKC) is a key output of the Par complex as phosphorylation removes substrates from the Par domain. Here, we investigate how diverse, apparently unrelated Par substrates couple phosp...

journal_title：Developmental cell

authors： Bailey MJ,Prehoda KE

更新日期：2015-10-26 00:00:00

abstract：:The ability of the death ligand TRAIL to induce tumor cell apoptosis has led to the development of TRAIL-based cancer therapies. Reporting recently in Molecular Cell, Lu et al. (2014) show that the basis for differential TRAIL responses involves clustering of death receptor complexes by E-cadherin and the actin cytosk...

journal_title：Developmental cell

authors： Gallegos LL,Brugge JS

更新日期：2014-07-14 00:00:00

abstract：:Oxysterol binding protein-related proteins (ORPs) are conserved lipid binding polypeptides, enriched at ER contacts sites. ORPs promote non-vesicular lipid transport and work as lipid sensors in the context of many cellular tasks, but the determinants of their distinct localization and function are not understood. Her...

journal_title：Developmental cell

authors： Encinar Del Dedo J,Idrissi FZ,Fernandez-Golbano IM,Garcia P,Rebollo E,Krzyzanowski MK,Grötsch H,Geli MI

更新日期：2017-12-04 00:00:00

abstract：:The connection between cell fate transitions and metabolic shifts is gaining momentum in the study of cell differentiation in embryonic development, adult stem cells, and cancer pathogenesis. Here, we explore how metabolic transitions influence post-translational modifications (PTMs), which play central roles in the a...

journal_title：Developmental cell

authors： Tarazona OA,Pourquié O

更新日期：2020-07-20 00:00:00

abstract：:Novel body structures are often generated by the redeployment of ancestral components of the genome. In this issue of Developmental Cell, Glassford et al. (2015) present a thorough analysis of the co-option of a gene regulatory network in the origin of an evolutionary novelty. ...

journal_title：Developmental cell

authors： Preger-Ben Noon E,Frankel N

更新日期：2015-09-14 00:00:00

abstract：:One G protein-coupled receptor (GPCR) can activate more than one G protein, but the physiologic importance of such activation has not been demonstrated in vivo. We have generated mice expressing exclusively a mutant form of the PTH/PTHrP receptor (DSEL) that activates adenylyl cyclase normally but not phospholipase C ...

journal_title：Developmental cell

authors： Guo J,Chung UI,Kondo H,Bringhurst FR,Kronenberg HM

更新日期：2002-08-01 00:00:00

abstract：:T-box genes encode DNA binding transcription factors known to regulate a wide variety of developmental processes during embryogenesis and are present in the genomes of all multicellular animals. Indeed, alongside other more familiar families of developmental regulators such as Hox, Sox, and Pax, T-box genes constitute...

journal_title：Developmental cell

authors： Gibson-Brown JJ

更新日期：2002-11-01 00:00:00

abstract：:The binding of Hedgehog (Hh) to its receptor Patched causes derepression of Smoothened (Smo), resulting in the activation of the Hh pathway. Here, we show that Smo activation is dependent on the levels of the phospholipid phosphatidylinositol-4 phosphate (PI4P). Loss of STT4 kinase, which is required for the generatio...

journal_title：Developmental cell

authors： Yavari A,Nagaraj R,Owusu-Ansah E,Folick A,Ngo K,Hillman T,Call G,Rohatgi R,Scott MP,Banerjee U

更新日期：2010-07-20 00:00:00

abstract：:The developmental mechanisms that orchestrate differentiation of specific nephron segments are incompletely understood, and the factors that maintain their terminal differentiation after nephrogenesis remain largely unknown. Here, the transcription factor AP-2β is shown to be required for the differentiation of distal...

journal_title：Developmental cell

authors： Marneros AG

更新日期：2020-08-10 00:00:00

abstract：:Oncogenic alterations in epithelial tissues often trigger apoptosis, suggesting an evolutionary mechanism by which organisms eliminate aberrant cells from epithelia. In Drosophila imaginal epithelia, clones of cells mutant for tumor suppressors, such as scrib or dlg, lose their polarity and are eliminated by cell deat...

journal_title：Developmental cell

authors： Igaki T,Pastor-Pareja JC,Aonuma H,Miura M,Xu T

更新日期：2009-03-01 00:00:00

abstract：:Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players. ...

journal_title：Developmental cell

authors： Donaldson JG

更新日期：2003-10-01 00:00:00

abstract：:Efficient regeneration following injury is critical for maintaining tissue function and enabling organismal survival. Cells reconstituting damaged tissue are often generated from resident stem or progenitor cells or from cells that have dedifferentiated and become proliferative. While lineage-tracing studies have defi...

journal_title：Developmental cell

authors： Iyengar S,Kasheta M,Ceol CJ

更新日期：2015-06-22 00:00:00

abstract：:A paper in the February issue of Molecular Cell describes the structure of the apoptosome, a multicomponent death machine, deciphered by cryoelectron microscopy. This structure explains the assembly of the machine, the tentative location of the subcomponents, and proposes a mechanism for initiating the death signal. ...

journal_title：Developmental cell

authors： Salvesen GS,Renatus M

更新日期：2002-03-01 00:00:00

abstract：:The Hippo/Yki and RB/E2F pathways both regulate tissue growth by affecting cell proliferation and survival, but interactions between these parallel control systems are poorly defined. In this study, we demonstrate that interaction between Drosophila E2F1 and Sd disrupts Yki/Sd complex formation and thereby suppresses ...

journal_title：Developmental cell

authors： Zhang P,Pei C,Wang X,Xiang J,Sun BF,Cheng Y,Qi X,Marchetti M,Xu JW,Sun YP,Edgar BA,Yuan Z

更新日期：2017-12-04 00:00:00

abstract：:The viral genomes of alpha- and gamma-retroviruses follow an outbound route through the cytoplasm before assembling with the budding particle at the plasma membrane. We show here that murine leukemia virus (MLV) RNAs are transported on lysosomes and transferrin-positive endosomes. Transport on transferrin-positive ves...

journal_title：Developmental cell

authors： Basyuk E,Galli T,Mougel M,Blanchard JM,Sitbon M,Bertrand E

更新日期：2003-07-01 00:00:00

abstract：:Growth and development are coordinated by an array of intercellular communications. Known plant signaling molecules include phytohormones and hormone peptides. Although both classes can be implicated in the same developmental processes, little is known about the interplay between phytohormone action and peptide signal...

journal_title：Developmental cell

authors： Whitford R,Fernandez A,Tejos R,Pérez AC,Kleine-Vehn J,Vanneste S,Drozdzecki A,Leitner J,Abas L,Aerts M,Hoogewijs K,Baster P,De Groodt R,Lin YC,Storme V,Van de Peer Y,Beeckman T,Madder A,Devreese B,Luschnig C,Friml

更新日期：2012-03-13 00:00:00

abstract：:Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here...

journal_title：Developmental cell

authors： Bordt EA,Clerc P,Roelofs BA,Saladino AJ,Tretter L,Adam-Vizi V,Cherok E,Khalil A,Yadava N,Ge SX,Francis TC,Kennedy NW,Picton LK,Kumar T,Uppuluri S,Miller AM,Itoh K,Karbowski M,Sesaki H,Hill RB,Polster BM

更新日期：2017-03-27 00:00:00

abstract：:Earlier, we reported that S6K1(-/-) mice have reduced body fat mass, have elevated rates of lipolysis, have severely decreased adipocyte size, and are resistant to high fat diet (HFD)-induced obesity. Here we report that adipocytes of S6K1(-/-) mice on a HFD have the capacity to increase in size to a degree comparable...

journal_title：Developmental cell

authors： Carnevalli LS,Masuda K,Frigerio F,Le Bacquer O,Um SH,Gandin V,Topisirovic I,Sonenberg N,Thomas G,Kozma SC

更新日期：2010-05-18 00:00:00

abstract：:Metastasizing breast carcinoma cells have been hypothesized to mobilize tissue-invasive activity by co-opting the proteolytic systems employed by normal mammary epithelial cells undergoing branching morphogenesis. However, the critical effectors underlying morphogenesis remain unidentified, and their relationship to b...

journal_title：Developmental cell

authors： Feinberg TY,Zheng H,Liu R,Wicha MS,Yu SM,Weiss SJ

更新日期：2018-10-22 00:00:00

abstract：:Numerous signals drive the proliferative expansion of the distal endoderm and the underlying mesenchyme during lung branching morphogenesis, but little is known about how these signals are integrated. Here, we show by analysis of conditional double mutants that the two T-box transcription factor genes Tbx2 and Tbx3 ac...

journal_title：Developmental cell

authors： Lüdtke TH,Rudat C,Wojahn I,Weiss AC,Kleppa MJ,Kurz J,Farin HF,Moon A,Christoffels VM,Kispert A

更新日期：2016-10-24 00:00:00

abstract：:The identities of the ubiquitin-ligases active during myogenesis are largely unknown. Here we describe a RING-type E3 ligase complex specified by the adaptor protein, Ozz, a novel SOCS protein that is developmentally regulated and expressed exclusively in striated muscle. In mice, the absence of Ozz results in overt m...

journal_title：Developmental cell

authors： Nastasi T,Bongiovanni A,Campos Y,Mann L,Toy JN,Bostrom J,Rottier R,Hahn C,Conaway JW,Harris AJ,D'Azzo A

更新日期：2004-02-01 00:00:00

abstract：:Although autophagy is being pursued as a therapeutic target in clinical oncology trials, its effects on metastasis, the principal cause of cancer mortality, remain unclear. Here, we utilize mammary cancer models to temporally delete essential autophagy regulators during carcinoma progression. Though genetic ablation o...

journal_title：Developmental cell

authors： Marsh T,Kenific CM,Suresh D,Gonzalez H,Shamir ER,Mei W,Tankka A,Leidal AM,Kalavacherla S,Woo K,Werb Z,Debnath J

更新日期：2020-03-09 00:00:00

abstract：:TORC1 regulates growth and metabolism, in part, by influencing transcriptional programs. Here, we identify REPTOR and REPTOR-BP as transcription factors downstream of TORC1 that are required for ∼ 90% of the transcriptional induction that occurs upon TORC1 inhibition in Drosophila. Thus, REPTOR and REPTOR-BP are major...

journal_title：Developmental cell

authors： Tiebe M,Lutz M,De La Garza A,Buechling T,Boutros M,Teleman AA

更新日期：2015-05-04 00:00:00