Abstract：
:Asymmetric cell divisions generate cellular diversity. In Drosophila, embryonic neuroblasts target cell fate determinants basally, rotate their spindles by 90 degrees to align with the apical-basal axis, and divide asymmetrically in a stem cell-like fashion. In this process, apically localized Bazooka recruits Inscuteable and other proteins to form an apical complex, which then specifies spindle orientation and basal localization of the cell fate determinants and their adapter proteins such as Miranda. Here we report that Miranda localization requires the unconventional myosin VI Jaguar (Jar). In jar null mutant embryos, Miranda is delocalized and the spindle is misoriented, but the Inscuteable crescent remains apical. Miranda directly binds to Jar, raising the possibility that Miranda and its associated proteins are translocated basally by this actin-based motor. Our studies demonstrate that a class VI myosin is necessary for basal protein targeting and spindle orientation in neuroblasts.
journal_name
Dev Celljournal_title
Developmental cellauthors
Petritsch C,Tavosanis G,Turck CW,Jan LY,Jan YNdoi
10.1016/s1534-5807(03)00020-0keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
273-81issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(03)00020-0journal_volume
4pub_type
杂志文章abstract：:In vertebrate embryos, retinoic acid (RA) synthesized in the mesoderm by Raldh2 emanates to the hindbrain neuroepithelium, where it induces anteroposterior (AP)-restricted Hox expression patterns and rhombomere segmentation. However, how appropriate spatiotemporal RA activity is generated in the hindbrain is poorly un...
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更新日期：2013-03-25 00:00:00
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journal_title：Developmental cell
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pub_type： 评论,杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.05.010
更新日期：2010-06-15 00:00:00
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journal_title：Developmental cell
pub_type： 评论,杂志文章,评审
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journal_title：Developmental cell
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journal_title：Developmental cell
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