The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C.

abstract：:The interchromosome domain (ICD) model proposes that genes are selectively positioned at the surfaces of chromosome territories to facilitate their regulation. A paper in the May 13 issue of the Journal of Cell Biology provides evidence that supports a reinterpretation of this model. ...

journal_title：Developmental cell

authors： Kosak ST,Groudine M

更新日期：2002-06-01 00:00:00

abstract：:The 6th European Meiosis Workshop, sponsored by EMBO and organized by Franz Klein of the University of Vienna, met in mid-September. More than 150 participants who have not discovered anything more interesting than sex gathered in a bucolic Alpine valley near the town of Obertraun, Austria, surrounded by granite massi...

journal_title：Developmental cell

authors： Dernburg AF

更新日期：2003-11-01 00:00:00

abstract：:Sister chromatids are held together by the cohesin complex from the time they are made until cell division. In recent articles published in Cell and Current Biology, the characterization of Wapl, a newly identified cohesin-interacting protein, suggests that a dynamic interaction between the cohesin complex and chromat...

journal_title：Developmental cell

authors： Rankin S

更新日期：2006-12-01 00:00:00

abstract：:piRNAs are known to silence transposable elements, but not all piRNAs match transposon sequences. Recent studies from Shen et al. (2018) and Zhang et al. (2018) identify rules for piRNA target recognition in Caenorhabditis elegans. Permissive pairing rules allow targeting of essentially all germline mRNAs, while prote...

journal_title：Developmental cell

authors： Svendsen JM,Montgomery TA

更新日期：2018-03-26 00:00:00

abstract：:During chick gastrulation, inhibition of BMP signaling is required for primitive streak formation and induction of Hensen's node. We have identified a unique secreted protein, Tsukushi (TSK), which belongs to the Small Leucine-Rich Proteoglycan (SLRP) family and is expressed in the primitive streak and Hensen's node. ...

journal_title：Developmental cell

authors： Ohta K,Lupo G,Kuriyama S,Keynes R,Holt CE,Harris WA,Tanaka H,Ohnuma SI

更新日期：2004-09-01 00:00:00

abstract：:Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation...

journal_title：Developmental cell

authors： Wang X,Kopinke D,Lin J,McPherson AD,Duncan RN,Otsuna H,Moro E,Hoshijima K,Grunwald DJ,Argenton F,Chien CB,Murtaugh LC,Dorsky RI

更新日期：2012-09-11 00:00:00

abstract：:Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...

journal_title：Developmental cell

authors： Ewen-Campen B,Mohr SE,Hu Y,Perrimon N

更新日期：2017-10-09 00:00:00

abstract：:For 20 years, researchers have thought that circadian clocks are defined by feedback loops of transcription and translation. The rediscovery of posttranslational circadian oscillators in diverse organisms forces us to rethink this paradigm. Meanwhile, the original "basic" feedback loops of canonical circadian clocks h...

journal_title：Developmental cell

authors： Brown SA,Kowalska E,Dallmann R

更新日期：2012-03-13 00:00:00

abstract：:Intercellular communication is vital to tumor progression. In this issue of Developmental Cell, Bertolini et al. (2020) describe how small extracellular vesicles released from hypoxic mammary tumor cells facilitate intercellular communication, leading to alterations in mitochondrial dynamics and acquisition of invasiv...

journal_title：Developmental cell

authors： Boomgarden AC,Clancy JW,D'Souza-Schorey C

更新日期：2020-10-26 00:00:00

abstract：:Axillary meristems (AMs) give rise to lateral shoots and are critical to plant architecture. Understanding how developmental cues and environmental signals impact AM development will enable the improvement of plant architecture in agriculture. Here, we show that ARGONAUTE10 (AGO10), which sequesters miR165/166, promot...

journal_title：Developmental cell

authors： Zhang C,Fan L,Le BH,Ye P,Mo B,Chen X

更新日期：2020-12-07 00:00:00

abstract：:Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish "winners" from "losers" during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including ...

journal_title：Developmental cell

authors： Rhiner C,López-Gay JM,Soldini D,Casas-Tinto S,Martín FA,Lombardía L,Moreno E

更新日期：2010-06-15 00:00:00

abstract：:The adaptor complex AP-2 plays an important role in cargo selection and clathrin lattice formation during clathrin-mediated endocytosis. In a recent issue of Molecular Cell, Honing et al. demonstrate that high-affinity AP-2 membrane association is achieved through a combination of low-affinity interactions with membra...

journal_title：Developmental cell

authors： Gaidarov I,Keen JH

更新日期：2005-06-01 00:00:00

abstract：:The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transi...

journal_title：Developmental cell

authors： Jung H,Mazzoni EO,Soshnikova N,Hanley O,Venkatesh B,Duboule D,Dasen JS

更新日期：2014-04-28 00:00:00

abstract：:SAG/RBX2/ROC2 protein is an essential RING component of SCF E3 ubiquitin ligase. The role of SAG during embryogenesis remains unknown. We report a critical role for SAG in controlling vascular and neural development by modulating RAS activity via promoting degradation of neurofibromatosis type 1 (NF1). Mice mutant for...

journal_title：Developmental cell

authors： Tan M,Zhao Y,Kim SJ,Liu M,Jia L,Saunders TL,Zhu Y,Sun Y

更新日期：2011-12-13 00:00:00

abstract：:The monoallelic expression of imprinted genes is regulated by DNA methylation marks that originate from the oocyte or sperm. Li et al. (2008) show in this issue of Developmental Cell that the KRAB zinc finger protein Zfp57 contributes to the embryonic maintenance of these imprints. At one locus, Zfp57 is also involved...

journal_title：Developmental cell

authors： Hirasawa R,Feil R

更新日期：2008-10-01 00:00:00

abstract：:RhoA stimulates cell contractility by recruiting downstream effectors to the cortical plasma membrane. We now show that direct binding by anillin is required for effective signaling: this antagonizes the otherwise labile membrane association of GTP-RhoA to promote effector recruitment. However, since its binding to Rh...

journal_title：Developmental cell

authors： Budnar S,Husain KB,Gomez GA,Naghibosadat M,Varma A,Verma S,Hamilton NA,Morris RG,Yap AS

更新日期：2019-06-17 00:00:00

abstract：:Spindle positioning is an essential feature of asymmetric cell division. The conserved PAR proteins together with heterotrimeric G proteins control spindle positioning in animal cells, but how these are linked is not known. In C. elegans, PAR protein activity leads to asymmetric spindle placement through cortical asym...

journal_title：Developmental cell

authors： Panbianco C,Weinkove D,Zanin E,Jones D,Divecha N,Gotta M,Ahringer J

更新日期：2008-08-01 00:00:00

abstract：:The early midgut undergoes intensive elongation, but the underlying cellular and molecular mechanisms are unknown. The early midgut epithelium is pseudostratified, and its nuclei travel between apical and basal surfaces in concert with cell cycle. Using 3D confocal imaging and 2D live imaging, we profiled behaviors of...

journal_title：Developmental cell

authors： Wang S,Cebrian C,Schnell S,Gumucio DL

更新日期：2018-07-16 00:00:00

abstract：:The intestine is an organ with an exceptionally high rate of cell turnover, and perturbations in this process can lead to severe diseases such as cancer or intestinal atrophy. Nutrition has a profound impact on intestinal volume and cellular architecture. However, how intestinal homeostasis is maintained in fluctuatin...

journal_title：Developmental cell

authors： Mattila J,Kokki K,Hietakangas V,Boutros M

更新日期：2018-10-08 00:00:00

abstract：:The eukaryotic nucleus has been the neglected child of cell biology. The "International Symposium on Functional Organization of the Nucleus" held in January on Awaji Island, Japan, highlighted recent work on nuclear organization and function. Emerging from this conference was a holistic view in which diverse chemical ...

journal_title：Developmental cell

authors： Dernburg AF,Misteli T

更新日期：2007-03-01 00:00:00

abstract：:To maintain proper organ size, nature has devised trans-organ communication systems-involving both paracrine and circulating regulatory factors-to safeguard homeostasis. In this issue of Developmental Cell, Ji et al. (2019) now describe an enterohepatic feedback loop that balances tissue size and function in the mamma...

journal_title：Developmental cell

authors： Merrell AJ,Stanger BZ

更新日期：2019-02-25 00:00:00

abstract：:The Drosophila lipoprotein particle, Lipophorin, bears lipid-linked morphogens on its surface and is required for long-range signaling activity of Wingless and Hedgehog. Heparan sulfate proteoglycans are also critical for trafficking and signaling of these morphogens. Here we show that Lipophorin interacts with the he...

journal_title：Developmental cell

authors： Eugster C,Panáková D,Mahmoud A,Eaton S

更新日期：2007-07-01 00:00:00

abstract：:Changes to cell shape and interaction drive animal tissue morphogenesis. Reporting now in Developmental Cell, Del Signore et al. (2018) describe active lengthening of cell-cell contacts by Arp2/3-based actin networks. Through cycles of contact lengthening and shortening, the developing Drosophila eye passes through va...

journal_title：Developmental cell

authors： Zhang Y,Harris TJC

更新日期：2018-02-26 00:00:00

abstract：:Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H₂O₂)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly w...

journal_title：Developmental cell

authors： DeGennaro M,Hurd TR,Siekhaus DE,Biteau B,Jasper H,Lehmann R

更新日期：2011-02-15 00:00:00

abstract：:Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue...

journal_title：Developmental cell

authors： Shimada Y,Yonemura S,Ohkura H,Strutt D,Uemura T

更新日期：2006-02-01 00:00:00

abstract：:Centromere chromatin containing histone H3 variant CENP-A is required for accurate chromosome segregation as a foundation for kinetochore assembly. Human centromere chromatin assembles on a part of the long α-satellite (alphoid) DNA array, where it is flanked by pericentric heterochromatin. Heterochromatin spreads int...

journal_title：Developmental cell

authors： Ohzeki J,Shono N,Otake K,Martins NM,Kugou K,Kimura H,Nagase T,Larionov V,Earnshaw WC,Masumoto H

更新日期：2016-06-06 00:00:00

abstract：:The intricate interplay between NF-kappaB and JNK determines TNF-alpha cytotoxicity. In a recent Cell paper, report that prolonged JNK1 activation promotes TNF-alpha killing via E3 ligase-mediated degradation of the caspase 8 inhibitor cFLIP(L). On the other hand, Ventura et al. (2006) show in their recent Molecular C...

journal_title：Developmental cell

authors： Lin A

更新日期：2006-03-01 00:00:00

abstract：:The Hox family transcription factors control diversified morphogenesis during development and evolution. They function in concert with Pbc cofactor proteins. Pbc proteins bind the Hox hexapeptide (HX) motif and are thereby thought to confer DNA binding specificity. Here we report that mutation of the AbdA HX motif doe...

journal_title：Developmental cell

authors： Merabet S,Kambris Z,Capovilla M,Bérenger H,Pradel J,Graba Y

更新日期：2003-05-01 00:00:00

abstract：:The size of an organism is determined by the number and size of its constituent cells. The insulin/IGF-1 signaling systems have been long recognized to play a critical role in the determination of body size. Now the generation of mice deficient for a RhoGAP suggests that this small G protein might also regulate the gr...

journal_title：Developmental cell

authors： Birnbaum MJ

更新日期：2002-05-01 00:00:00

abstract：:Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types. This is especially critical during embryogenesis, when extensive cell proliferation, patterning, and migration events take place. Here we show that vertebrate primordial germ cells (PGCs) are pr...

journal_title：Developmental cell

authors： Gross-Thebing T,Yigit S,Pfeiffer J,Reichman-Fried M,Bandemer J,Ruckert C,Rathmer C,Goudarzi M,Stehling M,Tarbashevich K,Seggewiss J,Raz E

更新日期：2017-12-18 00:00:00