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A KRAB domain zinc finger protein in imprinting and disease.

Abstract：

:The monoallelic expression of imprinted genes is regulated by DNA methylation marks that originate from the oocyte or sperm. Li et al. (2008) show in this issue of Developmental Cell that the KRAB zinc finger protein Zfp57 contributes to the embryonic maintenance of these imprints. At one locus, Zfp57 is also involved in imprint establishment. These findings provide a mechanistic interpretation for Mackay et al.'s recently reported ZFP57 mutations in patients with transient neonatal diabetes.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Hirasawa R,Feil R

doi

10.1016/j.devcel.2008.09.006

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

487-8

issue

4

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(08)00387-0

journal_volume

15

pub_type

评论,杂志文章

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