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Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium.

Abstract：

:Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue involves assembly of a multiprotein complex that spans distal and proximal boundaries of adjacent cells. Here we pursue the mechanisms that place one of the components, Frizzled (Fz), at the distal side. Intracellular particles of GFP-tagged Fz moved preferentially toward distal boundaries before Fz::GFP and other components were tightly localized at the P/D cortex. Arrays of microtubules (MTs) were approximately oriented along the P-D axis and these MTs contributed to the formation of the cortical complex. Furthermore, there appeared to be a bias in the P-D MTs, with slightly more plus ends oriented distally. The hypothesis of polarized vesicular trafficking of Fz is discussed.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Shimada Y,Yonemura S,Ohkura H,Strutt D,Uemura T

doi

10.1016/j.devcel.2005.11.016

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

209-22

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(05)00476-4

journal_volume

10

pub_type

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