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FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation.

Abstract：

:Vertebrate gastrulation requires coordination of mesoderm specification with morphogenetic movements. While both of these processes require FGF signaling, it is not known how mesoderm specification and cell movements are coordinated during gastrulation. The related Sprouty and Spred protein families are recently discovered regulators of receptor tyrosine kinase signaling. We identified two genes for each family in Xenopus tropicalis: Xtsprouty1, Xtsprouty2, Xtspred1, and Xtspred2. In gain- and loss-of-function experiments we show that XtSprouty and XtSpred proteins modulate different signaling pathways downstream of the FGF receptor (FGFR), and consequently different developmental processes. Notably, XtSproutys inhibit morphogenesis and Ca(2+) and PKCdelta signaling, leaving MAPK activation and mesoderm specification intact. In contrast, XtSpreds inhibit MAPK activation and mesoderm specification, with little effect on Ca(2+) or PKCdelta signaling. These differences, combined with the timing of their developmental expression, suggest a mechanism to switch FGFR signal interpretation to coordinate mesoderm formation and cell movements during gastrulation.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Sivak JM,Petersen LF,Amaya E

doi

10.1016/j.devcel.2005.02.011

keywords:

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

689-701

issue

5

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(05)00084-5

journal_volume

8

pub_type

杂志文章

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