Abstract：
:MEF2 transcription factors are well-established regulators of muscle development. We have discovered an unanticipated role for MEF2C in the neural crest, where tissue-specific inactivation results in neonatal lethality due to severe craniofacial defects. We show that MEF2C is required for expression of the Dlx5, Dlx6, and Hand2 transcription factor genes in the branchial arches, and we identify a branchial arch-specific enhancer in the Dlx5/6 locus, which is activated synergistically by MEF2C and Dlx5, demonstrating that these factors interact to induce transcription. Mef2c and Dlx5/6 also interact genetically. Mice heterozygous for either Dlx5/6 or Mef2c are normal at birth and survive to weaning. By contrast, heterozygosity for both Mef2c and Dlx5/6 results in defective palate development and neonatal lethality. Taken together, the studies presented here define a feed-forward transcriptional circuit between the MADS-box transcription factor MEF2C and the homeodomain transcription factors Dlx5 and Dlx6 in craniofacial development.
journal_name
Dev Celljournal_title
Developmental cellauthors
Verzi MP,Agarwal P,Brown C,McCulley DJ,Schwarz JJ,Black BLdoi
10.1016/j.devcel.2007.03.007subject
Has Abstractpub_date
2007-04-01 00:00:00pages
645-52issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(07)00107-4journal_volume
12pub_type
杂志文章abstract：:We use the Dpp morphogen gradient in the Drosophila wing disc as a model to address the fundamental question of how a gradient of a growth factor can produce uniform growth. We first show that proper expression and subcellular localization of components in the Fat tumor-suppressor pathway, which have been argued to de...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.11.007
更新日期：2011-01-18 00:00:00
abstract：:Metastasizing breast carcinoma cells have been hypothesized to mobilize tissue-invasive activity by co-opting the proteolytic systems employed by normal mammary epithelial cells undergoing branching morphogenesis. However, the critical effectors underlying morphogenesis remain unidentified, and their relationship to b...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.08.025
更新日期：2018-10-22 00:00:00
abstract：:BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell proliferation in the mouse intestine and skin. However, it remains unknown whether BMP signaling can promote self-renewal of adult somatic stem cells. In this study, we sh...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.09.013
更新日期：2005-11-01 00:00:00
abstract：:Neutrophils, in response to a chemoattractant gradient, undergo dynamic F-actin remodeling, a process important for their directional migration or chemotaxis. However, signaling mechanisms for chemoattractants to regulate the process are incompletely understood. Here, we characterized chemoattractant-activated signali...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.10.023
更新日期：2011-12-13 00:00:00
abstract：:The Par polarity complex creates mutually exclusive cortical domains in diverse animal cells. Activity of the atypical protein kinase C (aPKC) is a key output of the Par complex as phosphorylation removes substrates from the Par domain. Here, we investigate how diverse, apparently unrelated Par substrates couple phosp...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.09.016
更新日期：2015-10-26 00:00:00
abstract：:Plants assemble beneficial root-associated microbiomes to support growth, especially in nutrient-poor conditions. To do so, however, plants have to suppress their immune system. Reporting in Nature, Castrillo et al. (2017) identified PHOSPHATE STARVATION RESPONSE1 (PHR1) as a central regulator in this balance between ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2017.03.019
更新日期：2017-04-10 00:00:00
abstract：:beta-Catenin signaling determines the proximal-distal axis of the C. elegans gonad by promoting distal fate in asymmetrically dividing somatic gonad precursor cells (SGPs). Impaired function of the Wnt effector POP-1/TCF, its coactivator SYS-1/beta-catenin, and of upstream components including beta-catenin WRM-1 cause...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.06.003
更新日期：2006-08-01 00:00:00
abstract：:Dickkopf-1 (Dkk1) is a secreted Wnt antagonist with a well-established role in head induction during development. Numerous studies have emerged implicating Dkk1 in various malignancies and neurodegenerative diseases through an unknown mechanism. Using zebrafish gastrulation as a model for collective cell migration, we...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.10.026
更新日期：2019-12-16 00:00:00
abstract：:The Arf tumor suppressor is a key component of the p53 tumor surveillance pathway, and its expression is activated by abnormal proliferation signals. In a recent paper, Lees and coworkers investigate the regulation of Arf expression by E2Fs and demonstrate that in normal cells E2F3 is a pivotal repressor of Arf. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.devcel.2004.05.012
更新日期：2004-06-01 00:00:00
abstract：:Oxysterol binding protein-related proteins (ORPs) are conserved lipid binding polypeptides, enriched at ER contacts sites. ORPs promote non-vesicular lipid transport and work as lipid sensors in the context of many cellular tasks, but the determinants of their distinct localization and function are not understood. Her...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.10.031
更新日期：2017-12-04 00:00:00
abstract：:Orientation of cell division is a vital aspect of tissue morphogenesis and growth. Asymmetric divisions generate cell fate diversity and epithelial stratification, whereas symmetric divisions contribute to tissue growth, spreading, and elongation. Here, we describe a mechanism for positioning the spindle in symmetric ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.01.002
更新日期：2012-04-17 00:00:00
abstract：:The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, c...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2007.03.020
更新日期：2007-04-01 00:00:00
abstract：:Hearts of mice lacking Isl1, a LIM homeodomain transcription factor, are completely missing the outflow tract, right ventricle, and much of the atria. isl1 expression and lineage tracing of isl1-expressing progenitors demonstrate that Isl1 is a marker for a distinct population of undifferentiated cardiac progenitors t...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00363-0
更新日期：2003-12-01 00:00:00
abstract：:Initiation of DNA replication must be restricted to occur only once per cell cycle. In most bacteria, DnaA protein binds replication origins and promotes the initiation of DNA replication. We have found that in Bacillus subtilis, DnaA only colocalizes with origin regions at early or late stages of the cell cycle, when...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.09.010
更新日期：2008-12-01 00:00:00
abstract：:TORC1 is arguably the best-studied regulator of cellular growth in eukaryotes. However, its activity has not been assessed in vivo in developing multicellular organisms. Two studies in this issue of Developmental Cell (Kim et al., 2017; Romero-Pozuelo et al., 2017) surprisingly reveal a patchy, cell-cycle-controlled p...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2017.08.007
更新日期：2017-08-21 00:00:00
abstract：:The noncoding Xist RNA triggers silencing of one of the two female X chromosomes during X inactivation in mammals. Gene silencing by Xist is restricted to a special developmental context in early embryos and specific hematopoietic precursors. Here, we show that Xist can initiate silencing in a lymphoma model. We ident...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.03.006
更新日期：2009-04-01 00:00:00
abstract：:Ribosomes perform protein synthesis but are also involved in signaling processes, the full extent of which are still being uncovered. We report that phenotypes of mutating ribosomal proteins (Rps) are largely due to signaling. Using Drosophila, we discovered that a bZip-domain protein, Xrp1, becomes elevated in Rp mut...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.07.003
更新日期：2018-08-20 00:00:00
abstract：:How kinetochores regulate microtubule dynamics to ensure proper kinetochore-microtubule interactions is unknown. Here, we studied this during early mitosis in Saccharomyces cerevisiae. When a microtubule shrinks and its plus end reaches a kinetochore bound to its lateral surface, the microtubule end attempts to tether...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.09.006
更新日期：2011-11-15 00:00:00
abstract：:A remarkable feature of development is its reproducibility, the ability to correct embryo-to-embryo variations and instruct precise patterning. In Drosophila, embryonic patterning along the anterior-posterior axis is controlled by the morphogen gradient Bicoid (Bcd). In this article, we describe quantitative studies o...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.09.004
更新日期：2008-10-01 00:00:00
abstract：:Eukaryotic genomes are organized within the nucleus through interactions with inner nuclear membrane (INM) proteins. How chromatin tethering to the INM is controlled in interphase and how this process contributes to subsequent mitotic nuclear envelope (NE) remodeling remains unclear. We have probed these fundamental q...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.01.028
更新日期：2020-04-06 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.11.005
更新日期：2020-12-07 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.06.009
更新日期：2004-07-01 00:00:00
abstract：:Passenger proteins migrate from inner centromeres to the spindle midzone during late mitosis, and those described to date are essential both for proper chromosome segregation and for completion of cell cleavage. We have purified and cloned the human passenger protein TD-60, and we here report that it is a member of th...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00205-3
更新日期：2003-08-01 00:00:00
abstract：:Caspase proteases execute apoptosis but also function in development. In this issue of Developmental Cell, Weaver et al. report that C. elegans CED-3 caspase promotes animal growth through PMK-1/p38 kinase cleavage, and at the expense of pathogen and stress immunity, revealing an unexpected homeostatic relationship be...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2020.04.006
更新日期：2020-05-04 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.05.002
更新日期：2016-06-06 00:00:00
abstract：:How adherens junctions (AJs) are formed upon cell division is largely unexplored. Here, we found that AJ formation is coordinated with cytokinesis and relies on an interplay between the dividing cell and its neighbors. During contraction of the cytokinetic ring, the neighboring cells locally accumulate Myosin II and p...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.11.019
更新日期：2013-02-11 00:00:00
abstract：:Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown (Rhee et al.,2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by the Wnt/beta-catenin...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2006.05.007
更新日期：2006-06-01 00:00:00
abstract：:In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targetin...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.07.026
更新日期：2014-09-08 00:00:00
abstract：:Messenger RNAs (mRNAs) are synthesized in the cell nucleus and transported through nuclear pores to the cytoplasm for protein synthesis. Reporting in Nature Cell Biology, Mor et al. now track in living cells in real time the journey of single mRNA molecules as they transit from nucleus to cytoplasm. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2010.05.021
更新日期：2010-06-15 00:00:00
abstract：:Somatic muscle formation in Drosophila requires fusion of muscle founder cells with fusion-competent myoblasts. In a genetic screen for genes that control muscle development, we identified antisocial (ants), a gene that encodes an ankyrin repeat-, TPR repeat-, and RING finger-containing protein, required for myoblast ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(01)00084-3
更新日期：2001-11-01 00:00:00
