E2F3-a novel repressor of the ARF/p53 pathway.

abstract：:While autophagy is thought to be an essential process in some cancer cells, it is unknown if or how such cancer cells can circumvent autophagy inhibition. To address this, we developed a CRISPR/Cas9 assay with dynamic live-cell imaging to measure acute effects of knockout (KO) of autophagy genes compared to known esse...

journal_title：Developmental cell

authors： Towers CG,Fitzwalter BE,Regan D,Goodspeed A,Morgan MJ,Liu CW,Gustafson DL,Thorburn A

更新日期：2019-09-23 00:00:00

abstract：:Macropinocytosis coordinates non-specific uptake of macromolecules and fluid. Cancers employ macropinocytosis to obtain nutrients to support their metabolic homeostasis. In this issue of Developmental Cell, Lee et al. (2019) report that glutamine deprivation boosts macropinocytosis via EGFR signaling induction, provid...

journal_title：Developmental cell

authors： Weerasekara VK,Patra KC,Bardeesy N

更新日期：2019-08-05 00:00:00

abstract：:Netrin-1 was recently proposed to play an important role in embryonic and pathological angiogenesis. However, data reported led to the apparently contradictory conclusions that netrin-1 is either a pro- or an antiangiogenic factor. Here, we reconcile these opposing observations by demonstrating that netrin-1 acts as a...

journal_title：Developmental cell

authors： Castets M,Coissieux MM,Delloye-Bourgeois C,Bernard L,Delcros JG,Bernet A,Laudet V,Mehlen P

更新日期：2009-04-01 00:00:00

abstract：:Theoretical modeling is central to elucidating underlying principles of emergent properties of complex systems. In cell and developmental biology, the last 15 years have witnessed a convergence of empirical and modeling approaches for fresh perspectives. The role of cell division in coordinating size, shape, and fate ...

journal_title：Developmental cell

authors： Bellaïche Y

更新日期：2016-09-26 00:00:00

abstract：:Embryonic organizers establish gradients of diffusible signaling molecules to pattern the surrounding cells. Here, we elucidate an additional mechanism of embryonic organizers that is a secondary consequence of morphogen signaling. Using pharmacological and localized transgenic perturbations, 4D imaging of the zebrafi...

journal_title：Developmental cell

authors： Das D,Jülich D,Schwendinger-Schreck J,Guillon E,Lawton AK,Dray N,Emonet T,O'Hern CS,Shattuck MD,Holley SA

更新日期：2019-06-17 00:00:00

abstract：:Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7-/- T cells are deficient in Fas-receptor-induced apoptosis and that TRPM7 channel activity participates in the apoptotic process and is regulated by caspa...

journal_title：Developmental cell

authors： Desai BN,Krapivinsky G,Navarro B,Krapivinsky L,Carter BC,Febvay S,Delling M,Penumaka A,Ramsey IS,Manasian Y,Clapham DE

更新日期：2012-06-12 00:00:00

abstract：:Major histocompatibility complex class Ib molecules may play a surprising role in pheromone detection in mammals. ...

journal_title：Developmental cell

authors： Scott K

更新日期：2003-03-01 00:00:00

abstract：:Strigolactones secreted by plant roots are exploited by parasitic plants as germination triggers, making their synthesis and signaling important targets for crop protection. Meanwhile, genetic analyses have identified several genes required for the synthesis and signaling of an unknown shoot branching inhibitor. Two r...

journal_title：Developmental cell

authors： Leyser O

更新日期：2008-09-01 00:00:00

abstract：:The TGF-beta family member Nodal is one of the most potent molecules known to an embryo. Studies on Nodal regulation thus far have focused on its transcription, maturation, and interaction with antagonists. Two recent studies on the role of microRNAs (miRNAs) in Nodal signaling now reveal that something important was ...

journal_title：Developmental cell

authors： Collignon J

更新日期：2007-10-01 00:00:00

abstract：:In yeast and animal cells, the sterol composition of membranes is a key factor that controls the polarity of membrane proteins by regulating their intracellular trafficking or lateral diffusion. A recent study in Nature Cell Biology demonstrates that plant sterols play a major role in the acquisition of cell polarity ...

journal_title：Developmental cell

authors： Jaillais Y,Gaude T

更新日期：2008-03-01 00:00:00

abstract：:The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the consequences of depleting breast cancer cells of SIRT1. We discovered tha...

journal_title：Developmental cell

authors： Latifkar A,Ling L,Hingorani A,Johansen E,Clement A,Zhang X,Hartman J,Fischbach C,Lin H,Cerione RA,Antonyak MA

更新日期：2019-05-06 00:00:00

abstract：:Secreted molecules coordinate organ function. In a recent issue of Cell, Hudry et al. (2019) uncover a Drosophila testis-midgut interaction via cytokine and citrate signaling that regulates intestinal metabolism, spermatogenesis, and food intake. This impressive study is a striking example of the role of spatial organ...

journal_title：Developmental cell

authors： Droujinine IA,Perrimon N

更新日期：2019-08-19 00:00:00

abstract：:Egg production declines with age in many species, a process linked with stem cell loss. Diet-dependent signaling has emerged as critical for stem cell maintenance during aging. Follicle stem cells (FSCs) in the Drosophila ovary are exquisitely responsive to diet-induced signals including Hedgehog (Hh) and insulin-IGF ...

journal_title：Developmental cell

authors： Singh T,Lee EH,Hartman TR,Ruiz-Whalen DM,O'Reilly AM

更新日期：2018-09-24 00:00:00

abstract：:Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players. ...

journal_title：Developmental cell

authors： Donaldson JG

更新日期：2003-10-01 00:00:00

abstract：:How adherens junctions (AJs) are formed upon cell division is largely unexplored. Here, we found that AJ formation is coordinated with cytokinesis and relies on an interplay between the dividing cell and its neighbors. During contraction of the cytokinetic ring, the neighboring cells locally accumulate Myosin II and p...

journal_title：Developmental cell

authors： Herszterg S,Leibfried A,Bosveld F,Martin C,Bellaiche Y

更新日期：2013-02-11 00:00:00

abstract：:Dominant VAPB mutations are implicated in neurodegenerative disease, including amyotrophic lateral sclerosis and spinal muscular atrophy. In the current issue, Han et al. (2012) uncover a mechanism through which the secreted VAPB MSP domain regulates actin organization and mitochondrial function in muscle cells throug...

journal_title：Developmental cell

authors： Long JB,Van Vactor D

更新日期：2012-02-14 00:00:00

abstract：:The Decapentaplegic and Notch signaling pathways are thought to direct regional specification in the Drosophila eye-antennal epithelium by controlling the expression of selector genes for the eye (Eyeless/Pax6, Eyes absent) and/or antenna (Distal-less). Here, we investigate the function of these signaling pathways in ...

journal_title：Developmental cell

authors： Kenyon KL,Ranade SS,Curtiss J,Mlodzik M,Pignoni F

更新日期：2003-09-01 00:00:00

abstract：:The shape of most complex organ systems arises from the directed migration of cohesive groups of cells. Here, we dissect the role of the chemokine guidance receptor Cxcr4b in regulating the collective migration of one such cohesive tissue, the zebrafish lateral line primordium. Using in vivo imaging, we show that the ...

journal_title：Developmental cell

authors： Haas P,Gilmour D

更新日期：2006-05-01 00:00:00

abstract：:In a recent issue of Nature, Bohnert and Kenyon (2017) describe a signaling pathway that prevents transgenerational inheritance of cytoplasmic protein aggregates. Fertilizing sperm trigger aggregate clearance in the ovum by a microautophagy-like effector mechanism mediated by inter-organelle communication between lyso...

journal_title：Developmental cell

authors： Patil CK,Denic V

更新日期：2018-01-08 00:00:00

abstract：:FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that comprise the mouse blastocyst. However, ERK signaling dynamics have never been directly visualized in live embryos. To address whether differential signaling is associated with particular cell fates and states, we generated a targe...

journal_title：Developmental cell

authors： Simon CS,Rahman S,Raina D,Schröter C,Hadjantonakis AK

更新日期：2020-11-09 00:00:00

abstract：:Spindle checkpoint silencing is crucial for cell-cycle progression, but mechanisms underlying this process remain mysterious. Two papers, one in this issue of Developmental Cell (Meadows et al., 2011) and one in Current Biology (Rosenberg et al., 2011), begin to show how phosphatase PP1-gamma connects chromosome-micro...

journal_title：Developmental cell

authors： Maldonado M,Kapoor TM

更新日期：2011-06-14 00:00:00

abstract：:Hox proteins gain specificity by interacting with TALE-class cofactors. In a recent issue of Cell and in this issue of Developmental Cell, Crocker et al. (2015) and Amin et al. (2015), respectively, demonstrate that non-canonical Hox/TALE binding sequences play a major role in the regionalized regulation of target gen...

journal_title：Developmental cell

authors： Merabet S,Lohmann I

更新日期：2015-02-09 00:00:00

abstract：:Protein transport between the ER and the Golgi in mammalian cells occurs via large pleiomorphic carriers, and most current models suggest that these are formed by the fusion of small ER-derived COPII vesicles. We have examined the dynamics and structural features of these carriers during and after their formation from...

journal_title：Developmental cell

authors： Mironov AA,Mironov AA Jr,Beznoussenko GV,Trucco A,Lupetti P,Smith JD,Geerts WJ,Koster AJ,Burger KN,Martone ME,Deerinck TJ,Ellisman MH,Luini A

更新日期：2003-10-01 00:00:00

abstract：:Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types. This is especially critical during embryogenesis, when extensive cell proliferation, patterning, and migration events take place. Here we show that vertebrate primordial germ cells (PGCs) are pr...

journal_title：Developmental cell

authors： Gross-Thebing T,Yigit S,Pfeiffer J,Reichman-Fried M,Bandemer J,Ruckert C,Rathmer C,Goudarzi M,Stehling M,Tarbashevich K,Seggewiss J,Raz E

更新日期：2017-12-18 00:00:00

abstract：:Although many features of neurogenesis during development and in the adult are intrinsic to the neurogenic cells themselves, the role of the microenvironment is irrefutable. The neurogenic niche is a melting pot of cells and factors that influence CNS development. How do the diverse elements assemble and when? How doe...

journal_title：Developmental cell

authors： Bjornsson CS,Apostolopoulou M,Tian Y,Temple S

更新日期：2015-02-23 00:00:00

abstract：:MEF2 transcription factors are well-established regulators of muscle development. We have discovered an unanticipated role for MEF2C in the neural crest, where tissue-specific inactivation results in neonatal lethality due to severe craniofacial defects. We show that MEF2C is required for expression of the Dlx5, Dlx6,...

journal_title：Developmental cell

authors： Verzi MP,Agarwal P,Brown C,McCulley DJ,Schwarz JJ,Black BL

更新日期：2007-04-01 00:00:00

abstract：:Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...

journal_title：Developmental cell

authors： Carballido-López R,Errington J

更新日期：2003-01-01 00:00:00

abstract：:Wingless (Wg) is a morphogen required for the patterning of many Drosophila tissues. Several lines of evidence implicate heparan sulfate-modified proteoglycans (HSPGs) such as Dally-like protein (Dlp) in the control of Wg distribution and signaling. We show that dlp is required to limit Wg levels in the matrix, contra...

journal_title：Developmental cell

authors： Kirkpatrick CA,Dimitroff BD,Rawson JM,Selleck SB

更新日期：2004-10-01 00:00:00

abstract：:Regulated turnover of integrin receptors is essential for cell adhesion and migration. Pathways selectively regulating β1-integrin recycling are implicated in cancer invasion and metastasis, yet proteins required for the internalization of this pro-invasive integrin remain to be identified. Here, we uncover formin-lik...

journal_title：Developmental cell

authors： Wang Y,Arjonen A,Pouwels J,Ta H,Pausch P,Bange G,Engel U,Pan X,Fackler OT,Ivaska J,Grosse R

更新日期：2015-08-24 00:00:00

abstract：:Renewing tissues have the remarkable ability to continually produce both proliferative progenitor and specialized differentiated cell types. How are complex milieus of microenvironmental signals interpreted to coordinate tissue-cell-type composition? Here, we investigate the responses of intestinal epithelium to indiv...

journal_title：Developmental cell

authors： Sanman LE,Chen IW,Bieber JM,Steri V,Trentesaux C,Hann B,Klein OD,Wu LF,Altschuler SJ

更新日期：2021-01-15 00:00:00