Interplay between the dividing cell and its neighbors regulates adherens junction formation during cytokinesis in epithelial tissue.

abstract：:High-molecular-weight hyaluronan, a major component of the extracellular matrix, is anti-oncogenic, whereas low-molecular-weight hyaluronan is pro-oncogenic, though the mechanisms underlying the size-dependent opposite bioactivities of hyaluronan remain uncertain. We show here that treatment with high-molecular-weight...

journal_title：Developmental cell

authors： Ooki T,Murata-Kamiya N,Takahashi-Kanemitsu A,Wu W,Hatakeyama M

更新日期：2019-05-20 00:00:00

abstract：:Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...

journal_title：Developmental cell

authors： Ewen-Campen B,Mohr SE,Hu Y,Perrimon N

更新日期：2017-10-09 00:00:00

abstract：:Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A. Propagation of CENP-A chromatin is uncoupled from DNA replication initiating only during mitotic exit. We now demonstrate that ...

journal_title：Developmental cell

authors： Silva MC,Bodor DL,Stellfox ME,Martins NM,Hochegger H,Foltz DR,Jansen LE

更新日期：2012-01-17 00:00:00

abstract：:The Arf tumor suppressor is a key component of the p53 tumor surveillance pathway, and its expression is activated by abnormal proliferation signals. In a recent paper, Lees and coworkers investigate the regulation of Arf expression by E2Fs and demonstrate that in normal cells E2F3 is a pivotal repressor of Arf. ...

journal_title：Developmental cell

authors： Ginsberg D

更新日期：2004-06-01 00:00:00

abstract：:Translation of ribosomal protein-coding mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in coordination with other cellular processes are poorly defined. Here, we show that subcellular localization of RP-mRNAs acts as a key regulator of their transla...

journal_title：Developmental cell

authors： Dermit M,Dodel M,Lee FCY,Azman MS,Schwenzer H,Jones JL,Blagden SP,Ule J,Mardakheh FK

更新日期：2020-11-09 00:00:00

abstract：:Axillary meristems (AMs) give rise to lateral shoots and are critical to plant architecture. Understanding how developmental cues and environmental signals impact AM development will enable the improvement of plant architecture in agriculture. Here, we show that ARGONAUTE10 (AGO10), which sequesters miR165/166, promot...

journal_title：Developmental cell

authors： Zhang C,Fan L,Le BH,Ye P,Mo B,Chen X

更新日期：2020-12-07 00:00:00

abstract：:We have identified and characterized a novel C. elegans gene, ced-12, that functions in the conserved GTPase signaling pathway mediated by CED-2/Crkll, CED-5/DOCK180, and CED-10/Rac to control cell migration and phagocytosis of apoptotic cells. We provide evidence that ced-12 likely acts upstream of ced-10 during cell...

journal_title：Developmental cell

authors： Wu YC,Tsai MC,Cheng LC,Chou CJ,Weng NY

更新日期：2001-10-01 00:00:00

abstract：:Apoptosis has been implicated in compensatory proliferation signaling (CPS), whereby dying cells induce proliferation in neighboring cells as a means to restore homeostasis. The nature of signaling between apoptotic cells and their neighboring cells remains largely unknown. Here we show that a fraction of apoptotic ce...

journal_title：Developmental cell

authors： Gupta KH,Goldufsky JW,Wood SJ,Tardi NJ,Moorthy GS,Gilbert DZ,Zayas JP,Hahm E,Altintas MM,Reiser J,Shafikhani SH

更新日期：2017-06-19 00:00:00

abstract：:The serine threonine kinase Akt is a core survival factor that underlies a variety of human diseases. Although regulatory phosphorylation and dephosphorylation have been well documented, the other posttranslational mechanisms that modulate Akt activity remain unclear. We show here that tetratricopeptide repeat domain ...

journal_title：Developmental cell

authors： Suizu F,Hiramuki Y,Okumura F,Matsuda M,Okumura AJ,Hirata N,Narita M,Kohno T,Yokota J,Bohgaki M,Obuse C,Hatakeyama S,Obata T,Noguchi M

更新日期：2009-12-01 00:00:00

abstract：:SAG/RBX2/ROC2 protein is an essential RING component of SCF E3 ubiquitin ligase. The role of SAG during embryogenesis remains unknown. We report a critical role for SAG in controlling vascular and neural development by modulating RAS activity via promoting degradation of neurofibromatosis type 1 (NF1). Mice mutant for...

journal_title：Developmental cell

authors： Tan M,Zhao Y,Kim SJ,Liu M,Jia L,Saunders TL,Zhu Y,Sun Y

更新日期：2011-12-13 00:00:00

abstract：:Normal cellular development and function require tight spatiotemporal control of actin assembly. Formins are potent actin assembly factors that protect the growing ends of actin filaments from capping proteins. However, it is unresolved how the duration of formin-mediated actin assembly events is controlled, whether f...

journal_title：Developmental cell

authors： Chesarone M,Gould CJ,Moseley JB,Goode BL

更新日期：2009-02-01 00:00:00

abstract：:Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we ...

journal_title：Developmental cell

authors： Centanin L,Dekanty A,Romero N,Irisarri M,Gorr TA,Wappner P

更新日期：2008-04-01 00:00:00

abstract：:Differentiated cells have evolved mechanisms to adapt the functions of the late secretory pathway to the specific needs of the organism. Reporting in this issue of Developmental Cell, Polishchuk et al. (2014) demonstrate that hepatocytes utilize a unique exocytic aspect of the late endosomal/lysosomal compartment to m...

journal_title：Developmental cell

authors： Gitlin JD

更新日期：2014-06-23 00:00:00

abstract：:Myosin phosphatase-targeting subunit 1 (MYPT1) binds to the catalytic subunit of protein phosphatase 1 (PP1C). This binding is believed to target PP1C to specific substrates including myosin II, thus controlling cellular contractility. Surprisingly, we found that during mitosis, mammalian MYPT1 binds to polo-like kina...

journal_title：Developmental cell

authors： Yamashiro S,Yamakita Y,Totsukawa G,Goto H,Kaibuchi K,Ito M,Hartshorne DJ,Matsumura F

更新日期：2008-05-01 00:00:00

abstract：:Appropriate axonal growth and connectivity are essential for functional wiring of the brain. Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations disrupt primary cilia function, are characterized by axonal tract malformations. However, little is known about how cilia-driven signaling r...

journal_title：Developmental cell

authors： Guo J,Otis JM,Suciu SK,Catalano C,Xing L,Constable S,Wachten D,Gupton S,Lee J,Lee A,Blackley KH,Ptacek T,Simon JM,Schurmans S,Stuber GD,Caspary T,Anton ES

更新日期：2019-12-16 00:00:00

abstract：:p120-catenin is an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. Despite recent advances in understanding the roles that p120-catenin and Kaiso play in downstream modulation of Wnt/beta-catenin signaling, the identity of t...

journal_title：Developmental cell

authors： Park JI,Ji H,Jun S,Gu D,Hikasa H,Li L,Sokol SY,McCrea PD

更新日期：2006-11-01 00:00:00

abstract：:Netrin-1 was recently proposed to play an important role in embryonic and pathological angiogenesis. However, data reported led to the apparently contradictory conclusions that netrin-1 is either a pro- or an antiangiogenic factor. Here, we reconcile these opposing observations by demonstrating that netrin-1 acts as a...

journal_title：Developmental cell

authors： Castets M,Coissieux MM,Delloye-Bourgeois C,Bernard L,Delcros JG,Bernet A,Laudet V,Mehlen P

更新日期：2009-04-01 00:00:00

abstract：:Gap junctions are present in most tissues and play essential roles in various biological processes. However, we know surprisingly little about the molecular mechanisms underlying gap junction formation. Here, we uncover the essential role of a conserved EGF- and laminin-G-domain-containing protein nlr-1/CASPR in the r...

journal_title：Developmental cell

authors： Meng L,Yan D

更新日期：2020-12-07 00:00:00

abstract：:Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for either Tet1 or Tet2 are viable, raising the question of whether these enzymes have overlapping roles in development. Here we have generated Tet1 and Tet2 double-knockout (DKO)...

journal_title：Developmental cell

authors： Dawlaty MM,Breiling A,Le T,Raddatz G,Barrasa MI,Cheng AW,Gao Q,Powell BE,Li Z,Xu M,Faull KF,Lyko F,Jaenisch R

更新日期：2013-02-11 00:00:00

abstract：:The Frizzled (Fz) receptor is required cell autonomously in Wnt/beta-catenin and planar cell polarity (PCP) signaling. In addition to these requirements, Fz acts nonautonomously during PCP establishment: wild-type cells surrounding fz(-) patches reorient toward the fz(-) cells. The molecular mechanism(s) of nonautonom...

journal_title：Developmental cell

authors： Wu J,Mlodzik M

更新日期：2008-09-01 00:00:00

abstract：:CPEB is a sequence-specific RNA binding protein that regulates translation during vertebrate oocyte maturation. Adult female CPEB knockout mice contained vestigial ovaries that were devoid of oocytes; ovaries from mid-gestation embryos contained oocytes that were arrested at the pachytene stage. Male CPEB null mice al...

journal_title：Developmental cell

authors： Tay J,Richter JD

更新日期：2001-08-01 00:00:00

abstract：:The majority of excitatory synaptic transmission in the brain occurs at dendritic spines, which are actin-rich protrusions on the dendrites. The asymmetric nature of these structures suggests that proteins regulating cell polarity might be involved in their formation. Indeed, the polarity protein PAR-3 is required for...

journal_title：Developmental cell

authors： Zhang H,Macara IG

更新日期：2008-02-01 00:00:00

abstract：:Cytokinins affect plant immunity to various pathogens; however, the mechanisms coupling plant-derived cytokinins to pathogen responses have been elusive. Here, we found that plant-derived cytokinins promote resistance of Arabidopsis to Pseudomonas syringae pv. tomato DC3000 (Pst). Modulated cytokinin levels or signali...

journal_title：Developmental cell

authors： Choi J,Huh SU,Kojima M,Sakakibara H,Paek KH,Hwang I

更新日期：2010-08-17 00:00:00

abstract：:The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney deve...

journal_title：Developmental cell

authors： Humbert PO,Gödde NJ

更新日期：2015-05-04 00:00:00

abstract：:Septins are polymerizing GTP binding proteins required for cortical organization during cytokinesis and other cellular processes. A mammalian septin gene Sept4 is expressed mainly in postmitotic neural cells and postmeiotic male germ cells. In mouse and human spermatozoa, SEPT4 and other septins are found in the annul...

journal_title：Developmental cell

authors： Ihara M,Kinoshita A,Yamada S,Tanaka H,Tanigaki A,Kitano A,Goto M,Okubo K,Nishiyama H,Ogawa O,Takahashi C,Itohara S,Nishimune Y,Noda M,Kinoshita M

更新日期：2005-03-01 00:00:00

abstract：:Microglia are the primary immune cells in the brain. Under physiological conditions, they typically stay in a "resting" state, with ramified processes continuously extending to and retracting from surrounding neural tissues. Whether and how such highly dynamic resting microglia functionally interact with surrounding n...

journal_title：Developmental cell

authors： Li Y,Du XF,Liu CS,Wen ZL,Du JL

更新日期：2012-12-11 00:00:00

abstract：:Embryonic development of the liver has been studied intensely, yielding insights that impact diverse areas of developmental and cell biology. Understanding the fundamental mechanisms that control hepatogenesis has also laid the basis for the rational differentiation of stem cells into cells that display many hepatic f...

journal_title：Developmental cell

authors： Si-Tayeb K,Lemaigre FP,Duncan SA

更新日期：2010-02-16 00:00:00

abstract：:Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to si...

journal_title：Developmental cell

authors： Graml V,Studera X,Lawson JLD,Chessel A,Geymonat M,Bortfeld-Miller M,Walter T,Wagstaff L,Piddini E,Carazo Salas RE

更新日期：2014-10-27 00:00:00

abstract：:In multicellular organisms, cell size is tightly controlled by nutrients and growth factors. Increasing ambient glucose induces enhanced protein synthesis and cell size. Continued exposure of cells to high glucose in vivo, as apparent under pathological conditions, results in cell hypertrophy and tissue damage. We dem...

journal_title：Developmental cell

authors： Wu L,Derynck R

更新日期：2009-07-01 00:00:00

abstract：:In this issue of Developmental Cell, Ren et al. (2019) identify the embryonic origin of cardiac pacemaker cells in zebrafish and implicate Wnt5b in promoting their differentiation. Furthermore, canonical Wnt activation in human stem cell-derived cardiac progenitors produces functional pacemaker cells in vitro, advanci...

journal_title：Developmental cell

authors： Burns CG,Burns CE

更新日期：2019-09-23 00:00:00