Abstract：
:We have identified and characterized a novel C. elegans gene, ced-12, that functions in the conserved GTPase signaling pathway mediated by CED-2/Crkll, CED-5/DOCK180, and CED-10/Rac to control cell migration and phagocytosis of apoptotic cells. We provide evidence that ced-12 likely acts upstream of ced-10 during cell migration and phagocytosis and that CED-12 physically interacts with CED-5 and forms a ternary complex with CED-2 in vitro. We propose that the formation and localization of a CED-2-CED-5-CED-12 ternary complex to the plasma membrane activates CED-10, leading to the cytoskeletal reorganization that occurs in the polarized extension of cell surfaces in engulfing cells and migrating cells. We suggest that CED-12 counterparts in higher organisms regulate cytoskeleton dynamics, as CED-12 does in C. elegans.
journal_name
Dev Celljournal_title
Developmental cellauthors
Wu YC,Tsai MC,Cheng LC,Chou CJ,Weng NYdoi
10.1016/s1534-5807(01)00056-9keywords:
subject
Has Abstractpub_date
2001-10-01 00:00:00pages
491-502issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(01)00056-9journal_volume
1pub_type
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