Abstract：
:Neutrophils are essential to the homeostatic mission of safeguarding host tissues, responding rapidly and diversely to breaches of the host's barriers to infection, and returning tissues to a sterile state. In response to specific stimuli, neutrophils extrude modified chromatin structures decorated with specific cytoplasmic and granular proteins called neutrophil extracellular traps (NETs). Several pathways lead to this unique form of cell death (NETosis). Extracellular chromatin may have evolved to defend eukaryotic organisms against infection, and its release has at least three functions: trapping and killing of microbes, amplifying immune responses, and inducing coagulation. Here we review neutrophil development and heterogeneity with a focus on NETs, NET formation, and their relevance in host defense and disease.
journal_name
Dev Celljournal_title
Developmental cellauthors
Sollberger G,Tilley DO,Zychlinsky Adoi
10.1016/j.devcel.2018.01.019subject
Has Abstractpub_date
2018-03-12 00:00:00pages
542-553issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(18)30054-6journal_volume
44pub_type
杂志文章,评审abstract：:Yeast cells track gradients of pheromones to locate mating partners. Intuition suggests that uniform distribution of pheromone receptors over the cell surface would yield optimal gradient sensing. However, yeast cells display polarized receptors. The benefit of such polarization was unknown. During gradient tracking, ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.10.024
更新日期：2015-11-23 00:00:00
abstract：:Integrin expression and activity have been strongly correlated with developmental and pathological processes involving cell invasion through basement membranes. The role of integrins in mediating these invasions, however, remains unclear. Utilizing the genetically and visually accessible model of anchor cell (AC) inva...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.06.006
更新日期：2009-08-01 00:00:00
abstract：:The dorsoventral axis of the Drosophila embryo is patterned by a gradient of bone morphogenetic protein (BMP) ligands. In a process requiring at least three additional extracellular proteins, a broad domain of weak signaling forms and then abruptly sharpens into a narrow dorsal midline peak. Using experimental and com...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.04.009
更新日期：2005-06-01 00:00:00
abstract：:Transmission of the human parasite Brugia malayi relies on the sustained production of larvae in blood. In this issue of Developmental Cell,Foray et al. (2018) use methods developed in the model nematode C. elegans to reveal how a symbiotic bacterium supports the female germ cell development underlying this massive fe...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.04.006
更新日期：2018-04-23 00:00:00
abstract：:Connecting phosphorylation events to kinases and phosphatases is key to understanding the molecular organization and signaling dynamics of networks. We have generated a validated set of transgenic RNA-interference reagents for knockdown and characterization of all protein kinases and phosphatases present during early ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.07.027
更新日期：2014-10-13 00:00:00
abstract：:The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting system. Although development of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlying this process remain obscure. Here, we used time-lapse microscopy together with several ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.09.001
更新日期：2013-11-11 00:00:00
abstract：:Earlier, we reported that S6K1(-/-) mice have reduced body fat mass, have elevated rates of lipolysis, have severely decreased adipocyte size, and are resistant to high fat diet (HFD)-induced obesity. Here we report that adipocytes of S6K1(-/-) mice on a HFD have the capacity to increase in size to a degree comparable...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.02.018
更新日期：2010-05-18 00:00:00
abstract：:A central enigma in epigenetics is how epigenetic factors are guided to specific genomic sites for their function. Previously, we reported that a Piwi-piRNA complex associates with the piRNA-complementary site in the Drosophila genome and regulates its epigenetic state. Here, we report that Piwi-piRNA complexes bind t...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.01.023
更新日期：2013-03-11 00:00:00
abstract：:Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules leading to the perception of smell. ORs are expressed in many tissues but their functions are largely unknown. We show multiple ORs display distinct mRNA expression patterns during myogenesis in vitro and muscle regeneration in vivo. ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.09.004
更新日期：2009-11-01 00:00:00
abstract：:Vertebrate hematopoiesis first produces primitive (embryonic) lineages and ultimately generates the definitive (adult) blood. Whereas definitive hematopoiesis may produce many diverse blood types via a common multipotent progenitor, primitive hematopoiesis has been thought to produce only erythrocytes or macrophages v...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.04.007
更新日期：2009-05-01 00:00:00
abstract：:Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate Rab GDP-GTP exchange factors (GEFs) FAM116A and AVL9 are required for cell migration. Rab14 and its GEF FAM116A localize to and act on an intermediate compartmen...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.04.010
更新日期：2012-05-15 00:00:00
abstract：:To maintain mechanical homeostasis, cells must recognize and respond to changes in cytoskeletal integrity. By imaging live cells expressing fluorescently tagged cytoskeletal proteins, we observed that actin stress fibers undergo local, acute, force-induced elongation and thinning events that compromise their stress tr...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.08.008
更新日期：2010-09-14 00:00:00
abstract：:Cell polarity plays a key role in the development of the central nervous system (CNS). Interestingly, disruption of cell polarity is seen in many cancers. ASPP2 is a haplo-insufficient tumor suppressor and an activator of the p53 family. In this study, we show that ASPP2 controls the polarity and proliferation of neur...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.06.003
更新日期：2010-07-20 00:00:00
abstract：:MicroRNAs are abundant in animal genomes, yet little is known about their functions in vivo. Here, we report the production of 80 new Drosophila miRNA mutants by targeted homologous recombination. These mutants remove 104 miRNAs. Together with 15 previously reported mutants, this collection includes 95 mutants deletin...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.11.029
更新日期：2014-12-22 00:00:00
abstract：:COPII vesicles assemble at ER subdomains called transitional ER (tER) sites, but the mechanism that generates tER sites is unknown. To study tER biogenesis, we analyzed the transmembrane protein Sec12, which initiates COPII vesicle formation. Sec12 is concentrated at discrete tER sites in the budding yeast Pichia past...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(04)00129-7
更新日期：2004-05-01 00:00:00
abstract：:In this issue of Developmental Cell, Gibson and colleagues (Ramanathan et al., 2019) investigate the relationship between size and shape in epithelial cells. They find that cell size impacts cell shape, with unexpected consequences for epithelial growth and morphogenesis, particularly the clonal dynamics of epithelial...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.09.015
更新日期：2019-10-07 00:00:00
abstract：:Apoptosis has been implicated in compensatory proliferation signaling (CPS), whereby dying cells induce proliferation in neighboring cells as a means to restore homeostasis. The nature of signaling between apoptotic cells and their neighboring cells remains largely unknown. Here we show that a fraction of apoptotic ce...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.05.014
更新日期：2017-06-19 00:00:00
abstract：:Exposing cells to folding stress causes a subset of their proteins to misfold and accumulate in inclusion bodies (IBs). IB formation and clearance are both active processes, but little is known about their mechanism. To shed light on this issue, we performed a screen with over 4,000 fluorescently tagged yeast proteins...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.04.015
更新日期：2015-06-08 00:00:00
abstract：:Germ cells, the cells that give rise to sperm and egg, maintain the potential to recreate all cell types in a new individual. This wide developmental potential, or totipotency, is manifested in unusual tumors called teratomas, in which germ cells undergo somatic differentiation. Although recent studies have implicated...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.08.003
更新日期：2009-09-01 00:00:00
abstract：:During embryonic development, cells must establish fates, morphologies, and behaviors in coordination with one another to form a functional body. A prevalent hypothesis for how this coordination is achieved is that each cell's fate and behavior is determined by a defined mixture of RNAs. Only recently has it become po...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.07.025
更新日期：2016-08-22 00:00:00
abstract：:Molecular signatures defining quiescence in muscle satellite cells (mSCs) remain enigmatic. In this issue of Developmental Cell, Yue et al. adapted an in vivo fixation approach to isolate dormant mSCs from healthy muscle. Characterizing the transcriptome from these cells, they identified intron retention as a novel ha...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2020.05.028
更新日期：2020-06-22 00:00:00
abstract：:The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell autonomously and nonautonomously. We demonstrate that these two activities of fz in planar polarity are temporally separable in both the eye and wing. The nonautonomous function is dishevelled (dsh...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00363-5
更新日期：2002-12-01 00:00:00
abstract：:The expression of autophagy and lysosomal genes is coordinated by the transcription factor EB (TFEB). In this issue of Developmental Cell, Chen et al. identify an evolutionary conserved mode of TFEB regulation, which entails the inhibition of TFEB phase separation in the nucleus by inositol polyphosphate multikinase. ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.11.005
更新日期：2020-12-07 00:00:00
abstract：:Tight junctions contribute to epithelial barrier function by selectively regulating the quantity and type of molecules that cross the paracellular barrier. Experimental approaches to evaluate the effectiveness of tight junctions are typically global, tissue-scale measures. Here, we introduce Zinc-based Ultrasensitive ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.01.016
更新日期：2019-02-25 00:00:00
abstract：:Drosophila neuroblasts sequentially express a set of four transcription factors that specify the fates of their progeny according to the successive order of their generation. In analogy to spatial coordinate genes that specify neuroblasts by position, these sequentially expressed genes can be called "temporal coordina...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(01)00047-8
更新日期：2001-09-01 00:00:00
abstract：:The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transi...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.03.008
更新日期：2014-04-28 00:00:00
abstract：:Processing bodies (P bodies) are discrete cytoplasmic foci to which mRNA is routed for degradation. In mammalian cells, they are also associated with miRNA-induced translational silencing and siRNA-induced mRNA degradation. In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting prot...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2005.08.003
更新日期：2005-09-01 00:00:00
abstract：:The eukaryotic cell cycle, driven by both transcriptional and posttranslational mechanisms, is the central molecular oscillator underlying tissue growth throughout animals. Although genome-wide studies have investigated cell-cycle-associated transcription in unicellular systems, global patterns of periodic transcripti...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.02.018
更新日期：2014-04-14 00:00:00
abstract：:In Drosophila, left/right (LR) asymmetry is apparent in the directional looping of the gut and male genitalia. The dextral orientation of the organs depends on the activity of a single gene, MyosinID (myoID), whose mutation leads to a fully inverted LR axis, thus revealing the activity of a recessive sinistral pathway...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.11.013
更新日期：2013-01-14 00:00:00
abstract：:During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell-cycle progression, and cytokinesis. Rac1 null cells migrate markedly less efficiently, but s...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.07.008
更新日期：2011-10-18 00:00:00
