Neutrophil Extracellular Traps: The Biology of Chromatin Externalization.

Abstract:

:Neutrophils are essential to the homeostatic mission of safeguarding host tissues, responding rapidly and diversely to breaches of the host's barriers to infection, and returning tissues to a sterile state. In response to specific stimuli, neutrophils extrude modified chromatin structures decorated with specific cytoplasmic and granular proteins called neutrophil extracellular traps (NETs). Several pathways lead to this unique form of cell death (NETosis). Extracellular chromatin may have evolved to defend eukaryotic organisms against infection, and its release has at least three functions: trapping and killing of microbes, amplifying immune responses, and inducing coagulation. Here we review neutrophil development and heterogeneity with a focus on NETs, NET formation, and their relevance in host defense and disease.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Sollberger G,Tilley DO,Zychlinsky A

doi

10.1016/j.devcel.2018.01.019

subject

Has Abstract

pub_date

2018-03-12 00:00:00

pages

542-553

issue

5

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(18)30054-6

journal_volume

44

pub_type

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