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Rab6 regulates transport and targeting of exocytotic carriers.

Abstract：

:Constitutive exocytosis delivers newly synthesized proteins, lipids, and other molecules from the Golgi apparatus to the cell surface. This process is mediated by vesicles, which bud off the trans-Golgi network, move along cytoskeletal filaments, and fuse with the plasma membrane. Here, we show that the small GTPase Rab6 marks exocytotic vesicles and, together with the microtubule plus-end-directed motor kinesin-1, stimulates their processive microtubule-based transport to the cell periphery. Furthermore, Rab6 directs targeting of secretory vesicles to plasma-membrane sites enriched in the cortical protein ELKS, a known Rab6 binding partner. Our data demonstrate that although Rab6 is not essential for secretion, it controls the organization of exocytosis within the cellular space.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Grigoriev I,Splinter D,Keijzer N,Wulf PS,Demmers J,Ohtsuka T,Modesti M,Maly IV,Grosveld F,Hoogenraad CC,Akhmanova A

doi

10.1016/j.devcel.2007.06.010

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

305-14

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(07)00259-6

journal_volume

13

pub_type

杂志文章

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