Cdk activity couples epigenetic centromere inheritance to cell cycle progression.

abstract：:Dickkopf-1 (Dkk1) is a secreted Wnt antagonist with a well-established role in head induction during development. Numerous studies have emerged implicating Dkk1 in various malignancies and neurodegenerative diseases through an unknown mechanism. Using zebrafish gastrulation as a model for collective cell migration, we...

journal_title：Developmental cell

authors： Johansson M,Giger FA,Fielding T,Houart C

更新日期：2019-12-16 00:00:00

abstract：:Sea squirts are simple invertebrate chordates. In this issue of Developmental Cell, Takatori et al. show nuclear migration within ascidian mesendodermal cells enables polarized localization of Not mRNA, which encodes a homeobox protein that distinguishes mesoderm from endoderm fates. The link between nuclear migration...

journal_title：Developmental cell

authors： Parton RM,Davis I

更新日期：2010-10-19 00:00:00

abstract：:The lymphatic system is crucial for fluid homeostasis, immune responses, and numerous pathological processes. However, the molecular mechanisms responsible for establishing the anatomical form of the lymphatic vascular network remain largely unknown. Here, we show that chemokine signaling provides critical guidance cu...

journal_title：Developmental cell

authors： Cha YR,Fujita M,Butler M,Isogai S,Kochhan E,Siekmann AF,Weinstein BM

更新日期：2012-04-17 00:00:00

abstract：:In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which the SSC-ECM interface is regulated and the outcome of such interactions on stem cell fate in vivo remain unknown. Here we demonstrate...

journal_title：Developmental cell

authors： Tang Y,Rowe RG,Botvinick EL,Kurup A,Putnam AJ,Seiki M,Weaver VM,Keller ET,Goldstein S,Dai J,Begun D,Saunders T,Weiss SJ

更新日期：2013-05-28 00:00:00

abstract：:In Drosophila, commitment of a cell to a sense organ precursor (SOP) fate requires bHLH proneural transcription factor upregulation, a process that depends in most cases on the interplay of proneural gene autoregulation and inhibitory Notch signaling. A subset of SOPs are selected by a recruitment pathway involving EG...

journal_title：Developmental cell

authors： zur Lage PI,Powell LM,Prentice DR,McLaughlin P,Jarman AP

更新日期：2004-11-01 00:00:00

abstract：:The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting system. Although development of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlying this process remain obscure. Here, we used time-lapse microscopy together with several ...

journal_title：Developmental cell

authors： Packard A,Georgas K,Michos O,Riccio P,Cebrian C,Combes AN,Ju A,Ferrer-Vaquer A,Hadjantonakis AK,Zong H,Little MH,Costantini F

更新日期：2013-11-11 00:00:00

abstract：:Genome condensation during mitosis presents a chromatin landscape largely inaccessible to RNA polymerase II and most transcription factors. Caravaca et al. (2013) now report in Genes and Development that the pioneer transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable gene ex...

journal_title：Developmental cell

authors： Rada-Iglesias A

更新日期：2013-02-25 00:00:00

abstract：:Integrin expression and activity have been strongly correlated with developmental and pathological processes involving cell invasion through basement membranes. The role of integrins in mediating these invasions, however, remains unclear. Utilizing the genetically and visually accessible model of anchor cell (AC) inva...

journal_title：Developmental cell

authors： Hagedorn EJ,Yashiro H,Ziel JW,Ihara S,Wang Z,Sherwood DR

更新日期：2009-08-01 00:00:00

abstract：:Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling. ...

journal_title：Developmental cell

authors： Perdiguero E,Serrano AL,Muñoz-Cánoves P

更新日期：2017-07-24 00:00:00

abstract：:Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types. This is especially critical during embryogenesis, when extensive cell proliferation, patterning, and migration events take place. Here we show that vertebrate primordial germ cells (PGCs) are pr...

journal_title：Developmental cell

authors： Gross-Thebing T,Yigit S,Pfeiffer J,Reichman-Fried M,Bandemer J,Ruckert C,Rathmer C,Goudarzi M,Stehling M,Tarbashevich K,Seggewiss J,Raz E

更新日期：2017-12-18 00:00:00

abstract：:Airway smooth muscle is best known for its role as an airway constrictor in diseases such as asthma. However, its function in lung development is debated. A prevalent model, supported by in vitro data, posits that airway smooth muscle promotes lung branching through peristalsis and pushing intraluminal fluid to branch...

journal_title：Developmental cell

authors： Young RE,Jones MK,Hines EA,Li R,Luo Y,Shi W,Verheyden JM,Sun X

更新日期：2020-04-06 00:00:00

abstract：:Stem cell differentiation involves a delicate balance of gene expression and transposon repression. In this issue of Developmental Cell, Shibata et al. (2016) show that a PIWI protein expressed in planarian stem cells is inherited by their differentiating descendants to ensure regenerative capacity of the flatworm via...

journal_title：Developmental cell

authors： Tharp ME,Bortvin A

更新日期：2016-05-09 00:00:00

abstract：:In Drosophila, left/right (LR) asymmetry is apparent in the directional looping of the gut and male genitalia. The dextral orientation of the organs depends on the activity of a single gene, MyosinID (myoID), whose mutation leads to a fully inverted LR axis, thus revealing the activity of a recessive sinistral pathway...

journal_title：Developmental cell

authors： Coutelis JB,Géminard C,Spéder P,Suzanne M,Petzoldt AG,Noselli S

更新日期：2013-01-14 00:00:00

abstract：:Epithelial reorganization involves coordinated changes in cell shapes and movements. This restructuring occurs during formation of placodes, ectodermal thickenings that initiate the morphogenesis of epithelial organs including hair, mammary gland, and tooth. Signaling pathways in ectodermal placode formation are well ...

journal_title：Developmental cell

authors： Ahtiainen L,Lefebvre S,Lindfors PH,Renvoisé E,Shirokova V,Vartiainen MK,Thesleff I,Mikkola ML

更新日期：2014-03-10 00:00:00

abstract：:Infectious, self-propagating protein aggregates (prions) as well as structurally related amyloid fibrils have traditionally been associated with neurodegenerative diseases in mammals. However, recent work in fungi indicates that prions are not simply aberrations of protein folding, but are in fact widespread, conserve...

journal_title：Developmental cell

authors： Osherovich LZ,Weissman JS

更新日期：2002-02-01 00:00:00

abstract：:In the field of breast biology, there is a growing appreciation for the "gatekeeping function" of basal cells during development and disease processes yet mechanisms regulating the generation of these cells are poorly understood. Here, we report that the proliferation of basal cells is controlled by SLIT/ROBO1 signali...

journal_title：Developmental cell

authors： Macias H,Moran A,Samara Y,Moreno M,Compton JE,Harburg G,Strickland P,Hinck L

更新日期：2011-06-14 00:00:00

abstract：:Microtubules are normally organized at centrosomes, but other sites can also serve as microtubule organizing centers (MTOCs). In this issue of Developmental Cell, Procter et al. (2018) show that the human cytomegalovirus virion assembly compartment acts as a dynamic Golgi-derived MTOC where EB3 nucleates microtubules ...

journal_title：Developmental cell

authors： Lyon SM,Kalejta RF

更新日期：2018-04-09 00:00:00

abstract：:Optimal cell performance depends on cell size and the appropriate relative size, i.e., scaling, of the nucleus. How nuclear scaling is regulated and contributes to cell function is poorly understood, especially in skeletal muscle fibers, which are among the largest cells, containing hundreds of nuclei. Here, we presen...

journal_title：Developmental cell

authors： Windner SE,Manhart A,Brown A,Mogilner A,Baylies MK

更新日期：2019-04-08 00:00:00

abstract：:Several genes are known to regulate circadian rhythms in Arabidopsis, but the identity of the central oscillator has not been established. LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved. Here we demonstrate that, as shown previously for CCA1, inactivation of LHY shortens the pe...

journal_title：Developmental cell

authors： Mizoguchi T,Wheatley K,Hanzawa Y,Wright L,Mizoguchi M,Song HR,Carré IA,Coupland G

更新日期：2002-05-01 00:00:00

abstract：:Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging. Here, we developed an optimized protocol for single-molecule transcript imaging in the intact pancreas and used it to identify a sub-po...

journal_title：Developmental cell

authors： Farack L,Golan M,Egozi A,Dezorella N,Bahar Halpern K,Ben-Moshe S,Garzilli I,Tóth B,Roitman L,Krizhanovsky V,Itzkovitz S

更新日期：2019-01-07 00:00:00

abstract：:Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown (Rhee et al.,2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by the Wnt/beta-catenin...

journal_title：Developmental cell

authors： Korswagen HC

更新日期：2006-06-01 00:00:00

abstract：:Although many features of neurogenesis during development and in the adult are intrinsic to the neurogenic cells themselves, the role of the microenvironment is irrefutable. The neurogenic niche is a melting pot of cells and factors that influence CNS development. How do the diverse elements assemble and when? How doe...

journal_title：Developmental cell

authors： Bjornsson CS,Apostolopoulou M,Tian Y,Temple S

更新日期：2015-02-23 00:00:00

abstract：:In a recent issue of Molecular Cell, Cairo et al. (2013) report that the spindle checkpoint protein Mad1 shuttles between unattached kinetochores and nuclear pores. Mobile Mad1 inhibits the import receptor Kap121p, thus indirectly changing spindle dynamics. This adds nuclear transport control to the mitotic roles of M...

journal_title：Developmental cell

authors： Dasso M

更新日期：2013-01-28 00:00:00

abstract：:MicroRNAs are abundant in animal genomes, yet little is known about their functions in vivo. Here, we report the production of 80 new Drosophila miRNA mutants by targeted homologous recombination. These mutants remove 104 miRNAs. Together with 15 previously reported mutants, this collection includes 95 mutants deletin...

journal_title：Developmental cell

authors： Chen YW,Song S,Weng R,Verma P,Kugler JM,Buescher M,Rouam S,Cohen SM

更新日期：2014-12-22 00:00:00

abstract：:The kinase Plk1 plays multiple roles in regulating mitotic progression, including stabilization of spindle poles, but its substrates are largely unknown. A new study by Yamamoto and coworkers has identified a centrosomal protein, Kizuna (Kiz), as a mitotic substrate of Plk1 (Oshimori et al., 2006). Phosphorylation of ...

journal_title：Developmental cell

authors： Fry AM,Baxter JE

更新日期：2006-10-01 00:00:00

abstract：:Lipid droplets are fat storage organelles in cells that physically resemble stable oil-water emulsion droplets. In this issue of Developmental Cell, Ben M'barek et al. (2017) show that the resemblance is more than superficial: physical principles governing emulsion stability also control lipid droplet nucleation and g...

journal_title：Developmental cell

authors： Roux A,Loewith R

更新日期：2017-06-19 00:00:00

abstract：:In this issue of Developmental Cell, Tang et al. (2018) and Li et al. (2018) combine genetic manipulation, mechanical perturbation, and live imaging to show how mechanical forces and local growth factors intersect to influence epithelial behavior and cell fate specification within the developing lung. ...

journal_title：Developmental cell

authors： Hogan BLM

更新日期：2018-02-05 00:00:00

abstract：:Myosin phosphatase-targeting subunit 1 (MYPT1) binds to the catalytic subunit of protein phosphatase 1 (PP1C). This binding is believed to target PP1C to specific substrates including myosin II, thus controlling cellular contractility. Surprisingly, we found that during mitosis, mammalian MYPT1 binds to polo-like kina...

journal_title：Developmental cell

authors： Yamashiro S,Yamakita Y,Totsukawa G,Goto H,Kaibuchi K,Ito M,Hartshorne DJ,Matsumura F

更新日期：2008-05-01 00:00:00

abstract：:Molecular signatures defining quiescence in muscle satellite cells (mSCs) remain enigmatic. In this issue of Developmental Cell, Yue et al. adapted an in vivo fixation approach to isolate dormant mSCs from healthy muscle. Characterizing the transcriptome from these cells, they identified intron retention as a novel ha...

journal_title：Developmental cell

authors： Nakka K,Kovac R,Wong MM,Dilworth FJ

更新日期：2020-06-22 00:00:00

abstract：:Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...

journal_title：Developmental cell

authors： Carballido-López R,Errington J

更新日期：2003-01-01 00:00:00