Chemokine signaling directs trunk lymphatic network formation along the preexisting blood vasculature.

Abstract:

:The lymphatic system is crucial for fluid homeostasis, immune responses, and numerous pathological processes. However, the molecular mechanisms responsible for establishing the anatomical form of the lymphatic vascular network remain largely unknown. Here, we show that chemokine signaling provides critical guidance cues directing early trunk lymphatic network assembly and patterning. The chemokine receptors Cxcr4a and Cxcr4b are expressed in lymphatic endothelium, whereas chemokine ligands Cxcl12a and Cxcl12b are expressed in adjacent tissues along which the developing lymphatics align. Loss- and gain-of-function studies in zebrafish demonstrate that chemokine signaling orchestrates the stepwise assembly of the trunk lymphatic network. In addition to providing evidence for a lymphatic vascular guidance mechanism, these results also suggest a molecular basis for the anatomical coalignment of lymphatic and blood vessels.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Cha YR,Fujita M,Butler M,Isogai S,Kochhan E,Siekmann AF,Weinstein BM

doi

10.1016/j.devcel.2012.01.011

subject

Has Abstract

pub_date

2012-04-17 00:00:00

pages

824-36

issue

4

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(12)00045-7

journal_volume

22

pub_type

杂志文章
  • A wapl a day keeps the sisters apart: wapl and cohesin dynamics.

    abstract::Sister chromatids are held together by the cohesin complex from the time they are made until cell division. In recent articles published in Cell and Current Biology, the characterization of Wapl, a newly identified cohesin-interacting protein, suggests that a dynamic interaction between the cohesin complex and chromat...

    journal_title:Developmental cell

    pub_type: 社论

    doi:10.1016/j.devcel.2006.11.010

    authors: Rankin S

    更新日期:2006-12-01 00:00:00

  • Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice.

    abstract::CPEB is a sequence-specific RNA binding protein that regulates translation during vertebrate oocyte maturation. Adult female CPEB knockout mice contained vestigial ovaries that were devoid of oocytes; ovaries from mid-gestation embryos contained oocytes that were arrested at the pachytene stage. Male CPEB null mice al...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(01)00025-9

    authors: Tay J,Richter JD

    更新日期:2001-08-01 00:00:00

  • Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology.

    abstract::The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2016.04.019

    authors: Desrochers LM,Antonyak MA,Cerione RA

    更新日期:2016-05-23 00:00:00

  • Terminating histone synthesis to preserve centromere integrity.

    abstract::Histone protein synthesis is activated as cells enter S phase to allow packaging of the newly replicated DNA into chromatin. In this issue of Developmental Cell, Takayama and coworkers elucidate a mechanism for silencing histone expression at the end of S phase in S. pombe. Failure to shut off histone expression disru...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2010.03.004

    authors: Marzluff WF

    更新日期:2010-03-16 00:00:00

  • Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles.

    abstract::Apoptosis has been implicated in compensatory proliferation signaling (CPS), whereby dying cells induce proliferation in neighboring cells as a means to restore homeostasis. The nature of signaling between apoptotic cells and their neighboring cells remains largely unknown. Here we show that a fraction of apoptotic ce...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2017.05.014

    authors: Gupta KH,Goldufsky JW,Wood SJ,Tardi NJ,Moorthy GS,Gilbert DZ,Zayas JP,Hahm E,Altintas MM,Reiser J,Shafikhani SH

    更新日期:2017-06-19 00:00:00

  • gurken and the I factor retrotransposon RNAs share common localization signals and machinery.

    abstract::Drosophila gurken mRNA is localized by dynein-mediated transport to a crescent near the oocyte nucleus, thus targeting the TGFalpha signal and forming the primary embryonic axes. Here, we show that gurken and the I factor, a non-LTR retrotransposon, share a small consensus RNA stem loop of defined secondary structure,...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2005.04.012

    authors: Van De Bor V,Hartswood E,Jones C,Finnegan D,Davis I

    更新日期:2005-07-01 00:00:00

  • Development or Disease: Caspases Balance Growth and Immunity in C. elegans.

    abstract::Caspase proteases execute apoptosis but also function in development. In this issue of Developmental Cell, Weaver et al. report that C. elegans CED-3 caspase promotes animal growth through PMK-1/p38 kinase cleavage, and at the expense of pathogen and stress immunity, revealing an unexpected homeostatic relationship be...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2020.04.006

    authors: Yarychkivska O,Shaham S

    更新日期:2020-05-04 00:00:00

  • Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation.

    abstract::Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA synthesis phase. Cyclin E expression is normally restricted to proliferating cells. However, high levels of cyclin E are expressed in the adult brain. The function of ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.08.009

    authors: Odajima J,Wills ZP,Ndassa YM,Terunuma M,Kretschmannova K,Deeb TZ,Geng Y,Gawrzak S,Quadros IM,Newman J,Das M,Jecrois ME,Yu Q,Li N,Bienvenu F,Moss SJ,Greenberg ME,Marto JA,Sicinski P

    更新日期:2011-10-18 00:00:00

  • A molecular switch for the orientation of epithelial cell polarization.

    abstract::The formation of epithelial tissues containing lumens requires not only the apical-basolateral polarization of cells, but also the coordinated orientation of this polarity such that the apical surfaces of neighboring cells all point toward the central lumen. Defects in extracellular matrix (ECM) signaling lead to inve...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2014.08.027

    authors: Bryant DM,Roignot J,Datta A,Overeem AW,Kim M,Yu W,Peng X,Eastburn DJ,Ewald AJ,Werb Z,Mostov KE

    更新日期:2014-10-27 00:00:00

  • Toward a new twist in Hox and TALE DNA-binding specificity.

    abstract::Hox proteins gain specificity by interacting with TALE-class cofactors. In a recent issue of Cell and in this issue of Developmental Cell, Crocker et al. (2015) and Amin et al. (2015), respectively, demonstrate that non-canonical Hox/TALE binding sequences play a major role in the regionalized regulation of target gen...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2015.01.030

    authors: Merabet S,Lohmann I

    更新日期:2015-02-09 00:00:00

  • Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche.

    abstract::The gut absorbs dietary nutrients and provides a barrier to xenobiotics and microbiome metabolites. To cope with toxin exposures, the intestinal epithelium is one of the most rapidly proliferating tissues in the body. The stem cell niche supplies essential signaling factors including Wnt proteins secreted by subepithe...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.07.023

    authors: Chee YC,Pahnke J,Bunte R,Adsool VA,Madan B,Virshup DM

    更新日期:2018-09-24 00:00:00

  • The CXCL12/CXCR4 Axis Plays a Critical Role in Coronary Artery Development.

    abstract::The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling in cardiac development and found that embryonic Cxcl12-null hearts lacked intra-ventricular coronary arteries (CAs) and exhibited absent or mispl...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2015.03.026

    authors: Ivins S,Chappell J,Vernay B,Suntharalingham J,Martineau A,Mohun TJ,Scambler PJ

    更新日期:2015-05-26 00:00:00

  • C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.

    abstract::We have identified and characterized a novel C. elegans gene, ced-12, that functions in the conserved GTPase signaling pathway mediated by CED-2/Crkll, CED-5/DOCK180, and CED-10/Rac to control cell migration and phagocytosis of apoptotic cells. We provide evidence that ced-12 likely acts upstream of ced-10 during cell...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(01)00056-9

    authors: Wu YC,Tsai MC,Cheng LC,Chou CJ,Weng NY

    更新日期:2001-10-01 00:00:00

  • A Hierarchical Regulatory Landscape during the Multiple Stages of EMT.

    abstract::Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive features underlined by major transcriptional and epigenetic reprogramming. However, most studies have focused on the endpoints of the EMT process, and the epistatic hierarchy of the transcriptional networks underlying EMT has remained...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.12.023

    authors: Meyer-Schaller N,Cardner M,Diepenbruck M,Saxena M,Tiede S,Lüönd F,Ivanek R,Beerenwinkel N,Christofori G

    更新日期:2019-02-25 00:00:00

  • Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models.

    abstract::Appropriate axonal growth and connectivity are essential for functional wiring of the brain. Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations disrupt primary cilia function, are characterized by axonal tract malformations. However, little is known about how cilia-driven signaling r...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.11.005

    authors: Guo J,Otis JM,Suciu SK,Catalano C,Xing L,Constable S,Wachten D,Gupton S,Lee J,Lee A,Blackley KH,Ptacek T,Simon JM,Schurmans S,Stuber GD,Caspary T,Anton ES

    更新日期:2019-12-16 00:00:00

  • PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts.

    abstract::Bazooka/Par-3 (Baz) is a key regulator of cell polarity in epithelial cells and neuroblasts (NBs). Phosphorylation of Baz by PAR-1 and aPKC is required for its function in epithelia, but little is known about the dephosphorylation mechanisms that antagonize the activities of these kinases or about the relevance of Baz...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.04.011

    authors: Krahn MP,Egger-Adam D,Wodarz A

    更新日期:2009-06-01 00:00:00

  • Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.

    abstract::Angiogenesis is responsible for tissue vascularization during development, as well as in pathological contexts, including cancer and ischemia. Vascular endothelial growth factors (VEGFs) regulate angiogenesis by acting through VEGF receptors to induce endothelial cell signaling. VEGF is processed in the extracellular ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2016.12.017

    authors: De Angelis JE,Lagendijk AK,Chen H,Tromp A,Bower NI,Tunny KA,Brooks AJ,Bakkers J,Francois M,Yap AS,Simons C,Wicking C,Hogan BM,Smith KA

    更新日期:2017-01-23 00:00:00

  • Combinatorial Contact Cues Specify Cell Division Orientation by Directing Cortical Myosin Flows.

    abstract::Cell division axes during development are specified in different orientations to establish multicellular assemblies, but the mechanisms that generate division axis diversity remain unclear. We show here that patterns of cell contact provide cues that diversify cell division orientation by modulating cortical non-muscl...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.06.020

    authors: Sugioka K,Bowerman B

    更新日期:2018-08-06 00:00:00

  • An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles.

    abstract::In vertebrates, the microtubule binding protein TPX2 is required for meiotic and mitotic spindle assembly. TPX2 is also known to bind to and activate Aurora A kinase and target it to the spindle. However, the relationship between the TPX2-Aurora A interaction and the role of TPX2 in spindle assembly is unclear. Here, ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2005.07.002

    authors: Ozlü N,Srayko M,Kinoshita K,Habermann B,O'toole ET,Müller-Reichert T,Schmalz N,Desai A,Hyman AA

    更新日期:2005-08-01 00:00:00

  • Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway.

    abstract::The regulated release of polypeptides has a central role in physiology, behavior, and development, but the mechanisms responsible for production of the large dense core vesicles (LDCVs) capable of regulated release have remained poorly understood. Recent work has implicated cytosolic adaptor protein AP-3 in the recrui...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.10.007

    authors: Asensio CS,Sirkis DW,Maas JW Jr,Egami K,To TL,Brodsky FM,Shu X,Cheng Y,Edwards RH

    更新日期:2013-11-25 00:00:00

  • Specific Isoforms of the Guanine-Nucleotide Exchange Factor dPix Couple Neuromuscular Synapse Growth to Muscle Growth.

    abstract::Developmental growth requires coordination between the growth rates of individual tissues and organs. Here, we examine how Drosophila neuromuscular synapses grow to match the size of their target muscles. We show that changes in muscle growth driven by autonomous modulation of insulin receptor signaling produce corres...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2020.05.015

    authors: Ho CH,Treisman JE

    更新日期:2020-07-06 00:00:00

  • Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming.

    abstract::Recent studies have demonstrated that MyoD initiates a feed-forward regulation of skeletal muscle gene expression, predicting that MyoD binds directly to many genes expressed during differentiation. We have used chromatin immunoprecipitation and high-throughput sequencing to identify genome-wide binding of MyoD in sev...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2010.02.014

    authors: Cao Y,Yao Z,Sarkar D,Lawrence M,Sanchez GJ,Parker MH,MacQuarrie KL,Davison J,Morgan MT,Ruzzo WL,Gentleman RC,Tapscott SJ

    更新日期:2010-04-20 00:00:00

  • Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1.

    abstract::Myosin phosphatase-targeting subunit 1 (MYPT1) binds to the catalytic subunit of protein phosphatase 1 (PP1C). This binding is believed to target PP1C to specific substrates including myosin II, thus controlling cellular contractility. Surprisingly, we found that during mitosis, mammalian MYPT1 binds to polo-like kina...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.02.013

    authors: Yamashiro S,Yamakita Y,Totsukawa G,Goto H,Kaibuchi K,Ito M,Hartshorne DJ,Matsumura F

    更新日期:2008-05-01 00:00:00

  • Mammalian limbs take flight.

    abstract::Tetrapod limbs display a great variety of forms and functions. In an attempt to understand factors influencing this diversity, Cretekos and colleagues, in a recent issue of Genes & Development, provide molecular insight into the evolution of wing morphology in bats. ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.01.011

    authors: Weatherbee SD

    更新日期:2008-02-01 00:00:00

  • Moving right along: how PP1 helps clear the checkpoint.

    abstract::Spindle checkpoint silencing is crucial for cell-cycle progression, but mechanisms underlying this process remain mysterious. Two papers, one in this issue of Developmental Cell (Meadows et al., 2011) and one in Current Biology (Rosenberg et al., 2011), begin to show how phosphatase PP1-gamma connects chromosome-micro...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2011.05.017

    authors: Maldonado M,Kapoor TM

    更新日期:2011-06-14 00:00:00

  • Essential role of TGF-beta signaling in glucose-induced cell hypertrophy.

    abstract::In multicellular organisms, cell size is tightly controlled by nutrients and growth factors. Increasing ambient glucose induces enhanced protein synthesis and cell size. Continued exposure of cells to high glucose in vivo, as apparent under pathological conditions, results in cell hypertrophy and tissue damage. We dem...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.05.010

    authors: Wu L,Derynck R

    更新日期:2009-07-01 00:00:00

  • NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.

    abstract::Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling functions require precise regulation of lysosomal cholesterol content. In Niemann-Pick type C (NPC), loss of the cholestero...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2020.11.016

    authors: Davis OB,Shin HR,Lim CY,Wu EY,Kukurugya M,Maher CF,Perera RM,Ordonez MP,Zoncu R

    更新日期:2020-12-07 00:00:00

  • Sex and the MHC.

    abstract::Major histocompatibility complex class Ib molecules may play a surprising role in pheromone detection in mammals. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章,评审

    doi:10.1016/s1534-5807(03)00066-2

    authors: Scott K

    更新日期:2003-03-01 00:00:00

  • Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo.

    abstract::Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the bloodstream, reach distant organs, and locally modify the microenvironment. However, visualizing these events in vivo still faces major hurdles. Here...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.01.014

    authors: Hyenne V,Ghoroghi S,Collot M,Bons J,Follain G,Harlepp S,Mary B,Bauer J,Mercier L,Busnelli I,Lefebvre O,Fekonja N,Garcia-Leon MJ,Machado P,Delalande F,López AA,Silva SG,Verweij FJ,van Niel G,Djouad F,Peinado H,Ca

    更新日期:2019-02-25 00:00:00

  • It takes a village: constructing the neurogenic niche.

    abstract::Although many features of neurogenesis during development and in the adult are intrinsic to the neurogenic cells themselves, the role of the microenvironment is irrefutable. The neurogenic niche is a melting pot of cells and factors that influence CNS development. How do the diverse elements assemble and when? How doe...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2015.01.010

    authors: Bjornsson CS,Apostolopoulou M,Tian Y,Temple S

    更新日期:2015-02-23 00:00:00