Abstract:
:The lymphatic system is crucial for fluid homeostasis, immune responses, and numerous pathological processes. However, the molecular mechanisms responsible for establishing the anatomical form of the lymphatic vascular network remain largely unknown. Here, we show that chemokine signaling provides critical guidance cues directing early trunk lymphatic network assembly and patterning. The chemokine receptors Cxcr4a and Cxcr4b are expressed in lymphatic endothelium, whereas chemokine ligands Cxcl12a and Cxcl12b are expressed in adjacent tissues along which the developing lymphatics align. Loss- and gain-of-function studies in zebrafish demonstrate that chemokine signaling orchestrates the stepwise assembly of the trunk lymphatic network. In addition to providing evidence for a lymphatic vascular guidance mechanism, these results also suggest a molecular basis for the anatomical coalignment of lymphatic and blood vessels.
journal_name
Dev Celljournal_title
Developmental cellauthors
Cha YR,Fujita M,Butler M,Isogai S,Kochhan E,Siekmann AF,Weinstein BMdoi
10.1016/j.devcel.2012.01.011subject
Has Abstractpub_date
2012-04-17 00:00:00pages
824-36issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(12)00045-7journal_volume
22pub_type
杂志文章abstract::Sister chromatids are held together by the cohesin complex from the time they are made until cell division. In recent articles published in Cell and Current Biology, the characterization of Wapl, a newly identified cohesin-interacting protein, suggests that a dynamic interaction between the cohesin complex and chromat...
journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 评论,杂志文章
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journal_title:Developmental cell
pub_type: 杂志文章
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journal_title:Developmental cell
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doi:10.1016/j.devcel.2018.12.023
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journal_title:Developmental cell
pub_type: 评论,杂志文章
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journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 杂志文章
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journal_title:Developmental cell
pub_type: 评论,杂志文章
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journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 杂志文章,评审
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