DjPiwiB: A Rich Nuclear Inheritance for Descendants of Planarian Stem Cells.

abstract：:Cell-to-cell communication coordinates the behavior of individual cells to establish organ patterning and development. Although mobile signals are known to be important in lateral root development, the role of plasmodesmata (PD)-mediated transport in this process has not been investigated. Here, we show that changes i...

journal_title：Developmental cell

authors： Benitez-Alfonso Y,Faulkner C,Pendle A,Miyashima S,Helariutta Y,Maule A

更新日期：2013-07-29 00:00:00

abstract：:The eukaryotic cell cycle, driven by both transcriptional and posttranslational mechanisms, is the central molecular oscillator underlying tissue growth throughout animals. Although genome-wide studies have investigated cell-cycle-associated transcription in unicellular systems, global patterns of periodic transcripti...

journal_title：Developmental cell

authors： Liang L,Haug JS,Seidel CW,Gibson MC

更新日期：2014-04-14 00:00:00

abstract：:In this issue of Developmental Cell, Ren et al. (2019) identify the embryonic origin of cardiac pacemaker cells in zebrafish and implicate Wnt5b in promoting their differentiation. Furthermore, canonical Wnt activation in human stem cell-derived cardiac progenitors produces functional pacemaker cells in vitro, advanci...

journal_title：Developmental cell

authors： Burns CG,Burns CE

更新日期：2019-09-23 00:00:00

abstract：:Lymphatic vessels are essential for tissue homeostasis and immune surveillance and contribute to pathological conditions. Lymphatic endothelium differentiates from veins and forms an independent vascular tree with only few connections to the venous circulation. Failure of blood and lymphatic vessel separation results ...

journal_title：Developmental cell

authors： Böhmer R,Neuhaus B,Bühren S,Zhang D,Stehling M,Böck B,Kiefer F

更新日期：2010-03-16 00:00:00

abstract：:Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essent...

journal_title：Developmental cell

authors： Miao R,Li M,Zhang Q,Yang C,Wang X

更新日期：2020-01-06 00:00:00

abstract：:Integrin expression and activity have been strongly correlated with developmental and pathological processes involving cell invasion through basement membranes. The role of integrins in mediating these invasions, however, remains unclear. Utilizing the genetically and visually accessible model of anchor cell (AC) inva...

journal_title：Developmental cell

authors： Hagedorn EJ,Yashiro H,Ziel JW,Ihara S,Wang Z,Sherwood DR

更新日期：2009-08-01 00:00:00

abstract：:The mTOR kinase controls cell growth, proliferation, and survival through two distinct multiprotein complexes, mTORC1 and mTORC2. mTOR and mLST8 are in both complexes, while raptor and rictor are part of only mTORC1 and mTORC2, respectively. To investigate mTORC1 and mTORC2 function in vivo, we generated mice deficien...

journal_title：Developmental cell

authors： Guertin DA,Stevens DM,Thoreen CC,Burds AA,Kalaany NY,Moffat J,Brown M,Fitzgerald KJ,Sabatini DM

更新日期：2006-12-01 00:00:00

abstract：:Asymmetric division, a hallmark of endospore development, generates two cells, a larger mother cell and a smaller forespore. Approximately 75% of the forespore chromosome must be translocated across the division septum into the forespore by the DNA translocase SpoIIIE. Asymmetric division also triggers cell-specific t...

journal_title：Developmental cell

authors： Mohamed A,Chan H,Luhur J,Bauda E,Gallet B,Morlot C,Cole L,Awad M,Crawford S,Lyras D,Rudner DZ,Rodrigues CDA

更新日期：2021-01-11 00:00:00

abstract：:Localization of the actin crosslinking protein, alpha-actinin, to the cleavage furrow has been previously reported. However, its functions during cytokinesis remain poorly understood. We have analyzed the functions of alpha-actinin during cytokinesis by a combination of molecular manipulations and imaging-based techni...

journal_title：Developmental cell

authors： Mukhina S,Wang YL,Murata-Hori M

更新日期：2007-10-01 00:00:00

abstract：:During the first five rounds of cell division in the mouse embryo, spindles assemble in the absence of centrioles. Spindle formation initiates around chromosomes, but the microtubule nucleating process remains unclear. Here we demonstrate that Plk4, a protein kinase known as a master regulator of centriole formation, ...

journal_title：Developmental cell

authors： Coelho PA,Bury L,Sharif B,Riparbelli MG,Fu J,Callaini G,Glover DM,Zernicka-Goetz M

更新日期：2013-12-09 00:00:00

abstract：:The biogenesis of lipid droplets (LDs) and the development of adipocytes are two key aspects of mammalian fat storage. SEIPIN, an integral membrane protein of the endoplasmic reticulum (ER), plays a critical role in both LD formation and adipogenesis. The molecular function of SEIPIN, however, has yet to be elucidated...

journal_title：Developmental cell

authors： Yan R,Qian H,Lukmantara I,Gao M,Du X,Yan N,Yang H

更新日期：2018-10-22 00:00:00

abstract：:Understanding the mechanisms driving tissue and organ formation requires knowledge across scales. How do signaling pathways specify distinct tissue types? How does the patterning system control morphogenesis? How do these processes evolve? The Drosophila egg chamber, where EGF and BMP signaling intersect to specify un...

journal_title：Developmental cell

authors： Osterfield M,Berg CA,Shvartsman SY

更新日期：2017-05-22 00:00:00

abstract：:During zebrafish gastrulation, mesendoderm progenitor cells differentiate to mesoderm or endoderm cells. In this issue of Developmental Cell, Barone and colleagues (2017) show that the interplay between cell-cell contact duration and morphogen signaling can control this fate segregation, providing a new framework for ...

journal_title：Developmental cell

authors： Chan CJ,Hiiragi T

更新日期：2017-10-23 00:00:00

abstract：:The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell autonomously and nonautonomously. We demonstrate that these two activities of fz in planar polarity are temporally separable in both the eye and wing. The nonautonomous function is dishevelled (dsh...

journal_title：Developmental cell

authors： Strutt H,Strutt D

更新日期：2002-12-01 00:00:00

abstract：:In multicellular organisms, cell size is tightly controlled by nutrients and growth factors. Increasing ambient glucose induces enhanced protein synthesis and cell size. Continued exposure of cells to high glucose in vivo, as apparent under pathological conditions, results in cell hypertrophy and tissue damage. We dem...

journal_title：Developmental cell

authors： Wu L,Derynck R

更新日期：2009-07-01 00:00:00

abstract：:The large GTPase Dynamin 2 (Dyn2) is markedly upregulated in pancreatic cancer, is a potent activator of metastatic migration, and is required for Rac1-mediated formation of lamellipodia. Here we demonstrate an unexpected mechanism of Dyn2 action in these contexts via direct binding to the Rac1 guanine nucleotide exch...

journal_title：Developmental cell

authors： Razidlo GL,Wang Y,Chen J,Krueger EW,Billadeau DD,McNiven MA

更新日期：2013-03-25 00:00:00

abstract：:Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear. Here, we show that mice lacking Gadd45γ also exhibit XY gonadal sex reversal ca...

journal_title：Developmental cell

authors： Warr N,Carre GA,Siggers P,Faleato JV,Brixey R,Pope M,Bogani D,Childers M,Wells S,Scudamore CL,Tedesco M,del Barco Barrantes I,Nebreda AR,Trainor PA,Greenfield A

更新日期：2012-11-13 00:00:00

abstract：:hunchback regulates the temporal identity of neuroblasts in Drosophila. Here we show that hbl-1, the C. elegans hunchback ortholog, also controls temporal patterning. Furthermore, hbl-1 is a probable target of microRNA regulation through its 3'UTR. hbl-1 loss-of-function causes the precocious expression of adult seam ...

journal_title：Developmental cell

authors： Lin SY,Johnson SM,Abraham M,Vella MC,Pasquinelli A,Gamberi C,Gottlieb E,Slack FJ

更新日期：2003-05-01 00:00:00

abstract：:The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling in cardiac development and found that embryonic Cxcl12-null hearts lacked intra-ventricular coronary arteries (CAs) and exhibited absent or mispl...

journal_title：Developmental cell

authors： Ivins S,Chappell J,Vernay B,Suntharalingham J,Martineau A,Mohun TJ,Scambler PJ

更新日期：2015-05-26 00:00:00

abstract：:Myosin phosphatase-targeting subunit 1 (MYPT1) binds to the catalytic subunit of protein phosphatase 1 (PP1C). This binding is believed to target PP1C to specific substrates including myosin II, thus controlling cellular contractility. Surprisingly, we found that during mitosis, mammalian MYPT1 binds to polo-like kina...

journal_title：Developmental cell

authors： Yamashiro S,Yamakita Y,Totsukawa G,Goto H,Kaibuchi K,Ito M,Hartshorne DJ,Matsumura F

更新日期：2008-05-01 00:00:00

abstract：:Polarized delivery of signaling and adhesion molecules to the leading edge is required for directional migration of cells. Here, we describe a role for the PIP(2)-synthesizing enzyme, PIPKIγi2, in regulation of exocyst complex control of cell polarity and polarized integrin trafficking during migration. Loss of PIPKIγ...

journal_title：Developmental cell

authors： Thapa N,Sun Y,Schramp M,Choi S,Ling K,Anderson RA

更新日期：2012-01-17 00:00:00

abstract：:Preventing inappropriate gene expression in time and space is as fundamental as triggering the activation of tissue- or cell-type-specific factors at the correct developmental stage and in the correct cells. Here, we study the impact of Polycomb repressive complex 2 (PRC2) function on HoxA gene regulation. We analyze ...

journal_title：Developmental cell

authors： Gentile C,Berlivet S,Mayran A,Paquette D,Guerard-Millet F,Bajon E,Dostie J,Kmita M

更新日期：2019-07-22 00:00:00

abstract：:Secreted molecules coordinate organ function. In a recent issue of Cell, Hudry et al. (2019) uncover a Drosophila testis-midgut interaction via cytokine and citrate signaling that regulates intestinal metabolism, spermatogenesis, and food intake. This impressive study is a striking example of the role of spatial organ...

journal_title：Developmental cell

authors： Droujinine IA,Perrimon N

更新日期：2019-08-19 00:00:00

abstract：:Chronic inflammation is associated with tumorigenesis, but how acute inflammation affects the tumor microenvironment is less known. Recently, Antonio et al. (2015) found that neutrophils attracted to an acute wound such as a biopsy drive cell proliferation of nearby pre-neoplastic cells, suggesting that acute wounds m...

journal_title：Developmental cell

authors： Rosowski EE,Huttenlocher A

更新日期：2015-07-27 00:00:00

abstract：:Somatic muscle formation in Drosophila requires fusion of muscle founder cells with fusion-competent myoblasts. In a genetic screen for genes that control muscle development, we identified antisocial (ants), a gene that encodes an ankyrin repeat-, TPR repeat-, and RING finger-containing protein, required for myoblast ...

journal_title：Developmental cell

authors： Chen EH,Olson EN

更新日期：2001-11-01 00:00:00

abstract：:The gastrulating vertebrate embryo develops three germlayers: ectoderm, mesoderm, and endoderm. Zebrafish endoderm differentiation starts with the activation of sox17 by casanova (cas). We report that spg (pou2/Oct4) is essential for endoderm formation. Embryos devoid of maternal and zygotic spg function (MZspg) lack ...

journal_title：Developmental cell

authors： Reim G,Mizoguchi T,Stainier DY,Kikuchi Y,Brand M

更新日期：2004-01-01 00:00:00

abstract：:The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids once all chromosomes are attached via kinetochores by microtubules of the mitotic spindle. Reporting in Developmental Cell, Silió et al. (2015) show that in human cells the signaling cascade controlling the checkpoint ope...

journal_title：Developmental cell

authors： Meraldi P

更新日期：2015-12-07 00:00:00

abstract：:Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate Rab GDP-GTP exchange factors (GEFs) FAM116A and AVL9 are required for cell migration. Rab14 and its GEF FAM116A localize to and act on an intermediate compartmen...

journal_title：Developmental cell

authors： Linford A,Yoshimura S,Nunes Bastos R,Langemeyer L,Gerondopoulos A,Rigden DJ,Barr FA

更新日期：2012-05-15 00:00:00

abstract：:In migrating cells, Rho family GTPases and their effectors play a central role in polarizing and in organizing the actin and microtubule cytoskeletons. A study by Fukata et al. in the June 28th issue of Cell now shows that the Rac1/Cdc42 effector IQGAP1 captures microtubules by binding to CLIP170. ...

journal_title：Developmental cell

authors： Brunner D

更新日期：2002-07-01 00:00:00

abstract：:Embryonic development of the liver has been studied intensely, yielding insights that impact diverse areas of developmental and cell biology. Understanding the fundamental mechanisms that control hepatogenesis has also laid the basis for the rational differentiation of stem cells into cells that display many hepatic f...

journal_title：Developmental cell

authors： Si-Tayeb K,Lemaigre FP,Duncan SA

更新日期：2010-02-16 00:00:00