Luminal mitosis drives epithelial cell dispersal within the branching ureteric bud.

abstract：:In a recent issue of Molecular Cell, Cairo et al. (2013) report that the spindle checkpoint protein Mad1 shuttles between unattached kinetochores and nuclear pores. Mobile Mad1 inhibits the import receptor Kap121p, thus indirectly changing spindle dynamics. This adds nuclear transport control to the mitotic roles of M...

journal_title：Developmental cell

authors： Dasso M

更新日期：2013-01-28 00:00:00

abstract：:Tight junctions contribute to epithelial barrier function by selectively regulating the quantity and type of molecules that cross the paracellular barrier. Experimental approaches to evaluate the effectiveness of tight junctions are typically global, tissue-scale measures. Here, we introduce Zinc-based Ultrasensitive ...

journal_title：Developmental cell

authors： Stephenson RE,Higashi T,Erofeev IS,Arnold TR,Leda M,Goryachev AB,Miller AL

更新日期：2019-02-25 00:00:00

abstract：:We studied the role of the target of rapamycin complex 2 (mTORC2) during neutrophil chemotaxis, a process that is mediated through the polarization of actin and myosin filament networks. We show that inhibition of mTORC2 activity, achieved via knock down (KD) of Rictor, severely inhibits neutrophil polarization and di...

journal_title：Developmental cell

authors： Liu L,Das S,Losert W,Parent CA

更新日期：2010-12-14 00:00:00

abstract：:Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively stud...

journal_title：Developmental cell

authors： Curran S,Strandkvist C,Bathmann J,de Gennes M,Kabla A,Salbreux G,Baum B

更新日期：2017-11-20 00:00:00

abstract：:The ability of the death ligand TRAIL to induce tumor cell apoptosis has led to the development of TRAIL-based cancer therapies. Reporting recently in Molecular Cell, Lu et al. (2014) show that the basis for differential TRAIL responses involves clustering of death receptor complexes by E-cadherin and the actin cytosk...

journal_title：Developmental cell

authors： Gallegos LL,Brugge JS

更新日期：2014-07-14 00:00:00

abstract：:Nuclear size plays pivotal roles in gene expression, embryo development, and disease. A central hypothesis in organisms ranging from yeast to vertebrates is that nuclear size scales to cell size. This implies that nuclei may reach steady-state sizes set by limiting cytoplasmic pools of size-regulating components. By m...

journal_title：Developmental cell

authors： Mukherjee RN,Sallé J,Dmitrieff S,Nelson KM,Oakey J,Minc N,Levy DL

更新日期：2020-08-10 00:00:00

abstract：:The orientation of the mitotic spindle plays a key role in determining whether a polarized cell will divide symmetrically or asymmetrically. In most cell types, cytoplasmic dynein plays a critical role in spindle orientation. However, how dynein directs opposite spindle poles toward distinct and predetermined cell end...

journal_title：Developmental cell

authors： Grava S,Schaerer F,Faty M,Philippsen P,Barral Y

更新日期：2006-04-01 00:00:00

abstract：:Zebrafish heart regeneration occurs through the activation of cardiomyocyte proliferation in areas of trauma. Here, we show that within 3 hr of ventricular injury, the entire endocardium undergoes morphological changes and induces expression of the retinoic acid (RA)-synthesizing enzyme raldh2. By one day posttrauma, ...

journal_title：Developmental cell

authors： Kikuchi K,Holdway JE,Major RJ,Blum N,Dahn RD,Begemann G,Poss KD

更新日期：2011-03-15 00:00:00

abstract：:Translation of ribosomal protein-coding mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in coordination with other cellular processes are poorly defined. Here, we show that subcellular localization of RP-mRNAs acts as a key regulator of their transla...

journal_title：Developmental cell

authors： Dermit M,Dodel M,Lee FCY,Azman MS,Schwenzer H,Jones JL,Blagden SP,Ule J,Mardakheh FK

更新日期：2020-11-09 00:00:00

abstract：:Although we know that mesenchymal progenitors give rise to nephrons in the kidney, how they balance self-renewal versus differentiation is still unclear. In this issue of Developmental Cell, Chen et al. (2015) show that nephron progenitors age, but not necessarily irreversibly: old progenitors can be "rejuvenated" by ...

journal_title：Developmental cell

authors： Little MH

更新日期：2015-10-12 00:00:00

abstract：:For 20 years, researchers have thought that circadian clocks are defined by feedback loops of transcription and translation. The rediscovery of posttranslational circadian oscillators in diverse organisms forces us to rethink this paradigm. Meanwhile, the original "basic" feedback loops of canonical circadian clocks h...

journal_title：Developmental cell

authors： Brown SA,Kowalska E,Dallmann R

更新日期：2012-03-13 00:00:00

abstract：:Gastric acid secretion by parietal cells requires trafficking and exocytosis of H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation via cyclic AMP elevation. Here, we found that TRPML1 (ML1), a protein that is mutated in type IV mucolipidosis (ML-IV), is a tubulovesicular ...

journal_title：Developmental cell

authors： Sahoo N,Gu M,Zhang X,Raval N,Yang J,Bekier M,Calvo R,Patnaik S,Wang W,King G,Samie M,Gao Q,Sahoo S,Sundaresan S,Keeley TM,Wang Y,Marugan J,Ferrer M,Samuelson LC,Merchant JL,Xu H

更新日期：2017-05-08 00:00:00

abstract：:IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote ...

journal_title：Developmental cell

authors： Hassler J,Cao SS,Kaufman RJ

更新日期：2012-11-13 00:00:00

abstract：:Reporting in Cell, Berg et al. (2016) reveal a connection between genetic lysosomal storage disorders and the ability of macrophages to migrate and control mycobacterial infection. This insight, resulting from a zebrafish genetic screen, inspired the authors to propose an explanation for the increased susceptibility o...

journal_title：Developmental cell

authors： Meijer AH,Aerts JM

更新日期：2016-04-18 00:00:00

abstract：:The insulin-like peptide (ILP) family plays key biological roles in the control of body growth. Although the functions of ILPs are well understood, the mechanisms by which organisms sense their nutrient status and thereby control ILP production remain largely unknown. Here, we show that signaling relay and feedback me...

journal_title：Developmental cell

authors： Okamoto N,Nishimura T

更新日期：2015-11-09 00:00:00

abstract：:In vertebrate embryos, retinoic acid (RA) synthesized in the mesoderm by Raldh2 emanates to the hindbrain neuroepithelium, where it induces anteroposterior (AP)-restricted Hox expression patterns and rhombomere segmentation. However, how appropriate spatiotemporal RA activity is generated in the hindbrain is poorly un...

journal_title：Developmental cell

authors： Vitobello A,Ferretti E,Lampe X,Vilain N,Ducret S,Ori M,Spetz JF,Selleri L,Rijli FM

更新日期：2011-04-19 00:00:00

abstract：:Sea squirts are simple invertebrate chordates. In this issue of Developmental Cell, Takatori et al. show nuclear migration within ascidian mesendodermal cells enables polarized localization of Not mRNA, which encodes a homeobox protein that distinguishes mesoderm from endoderm fates. The link between nuclear migration...

journal_title：Developmental cell

authors： Parton RM,Davis I

更新日期：2010-10-19 00:00:00

abstract：:Plasma membrane subdomains enriched in sphingolipids, cholesterol, and signaling proteins are critical for organization of actin, membrane trafficking, and cell polarity, but the role of such domains in cytokinesis in animal cells is unknown. Here, we show that eggs form a plasma membrane domain enriched in gangliosid...

journal_title：Developmental cell

authors： Ng MM,Chang F,Burgess DR

更新日期：2005-12-01 00:00:00

abstract：:Secreted molecules coordinate organ function. In a recent issue of Cell, Hudry et al. (2019) uncover a Drosophila testis-midgut interaction via cytokine and citrate signaling that regulates intestinal metabolism, spermatogenesis, and food intake. This impressive study is a striking example of the role of spatial organ...

journal_title：Developmental cell

authors： Droujinine IA,Perrimon N

更新日期：2019-08-19 00:00:00

abstract：:Presenilins are components of the gamma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch proteins. A C. elegans genetic screen revealed two genes, aph-1 and pen-2, encoding multipass transmembrane proteins, that interact strongly with sel-12/presenilin and aph-2/nicastrin. Human ap...

journal_title：Developmental cell

authors： Francis R,McGrath G,Zhang J,Ruddy DA,Sym M,Apfeld J,Nicoll M,Maxwell M,Hai B,Ellis MC,Parks AL,Xu W,Li J,Gurney M,Myers RL,Himes CS,Hiebsch R,Ruble C,Nye JS,Curtis D

更新日期：2002-07-01 00:00:00

abstract：:Regulating cell proliferation and differentiation in CNS development requires both extraordinary complexity and precision. Neural progenitors receive graded overlapping signals from midline signaling centers, yet each makes a unique cell fate decision in a spatiotemporally restricted pattern. The Nde1-Lis1 complex reg...

journal_title：Developmental cell

authors： Lanctot AA,Peng CY,Pawlisz AS,Joksimovic M,Feng Y

更新日期：2013-05-13 00:00:00

abstract：:Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players. ...

journal_title：Developmental cell

authors： Donaldson JG

更新日期：2003-10-01 00:00:00

abstract：:Hearts of mice lacking Isl1, a LIM homeodomain transcription factor, are completely missing the outflow tract, right ventricle, and much of the atria. isl1 expression and lineage tracing of isl1-expressing progenitors demonstrate that Isl1 is a marker for a distinct population of undifferentiated cardiac progenitors t...

journal_title：Developmental cell

authors： Cai CL,Liang X,Shi Y,Chu PH,Pfaff SL,Chen J,Evans S

更新日期：2003-12-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive features underlined by major transcriptional and epigenetic reprogramming. However, most studies have focused on the endpoints of the EMT process, and the epistatic hierarchy of the transcriptional networks underlying EMT has remained...

journal_title：Developmental cell

authors： Meyer-Schaller N,Cardner M,Diepenbruck M,Saxena M,Tiede S,Lüönd F,Ivanek R,Beerenwinkel N,Christofori G

更新日期：2019-02-25 00:00:00

abstract：:All complex multicellular organisms must solve the problem of generating diverse and appropriately patterned cell types. Asymmetric division, in which a single mother cell gives rise to daughters with distinct identities, is instrumental in the generation of cellular diversity and higher-level patterns. In animal syst...

journal_title：Developmental cell

authors： Abrash EB,Bergmann DC

更新日期：2009-06-01 00:00:00

abstract：:The eukaryotic cell cycle, driven by both transcriptional and posttranslational mechanisms, is the central molecular oscillator underlying tissue growth throughout animals. Although genome-wide studies have investigated cell-cycle-associated transcription in unicellular systems, global patterns of periodic transcripti...

journal_title：Developmental cell

authors： Liang L,Haug JS,Seidel CW,Gibson MC

更新日期：2014-04-14 00:00:00

abstract：:The connection between cell fate transitions and metabolic shifts is gaining momentum in the study of cell differentiation in embryonic development, adult stem cells, and cancer pathogenesis. Here, we explore how metabolic transitions influence post-translational modifications (PTMs), which play central roles in the a...

journal_title：Developmental cell

authors： Tarazona OA,Pourquié O

更新日期：2020-07-20 00:00:00

abstract：:SnoN regulates multiple signaling pathways, including TGF-β/Smad and p53, and displays both pro-oncogenic and anti-oncogenic activities in human cancer. We have observed previously that both its intracellular localization and expression levels are sensitive to cell density, suggesting that it may crosstalk with Hippo ...

journal_title：Developmental cell

authors： Zhu Q,Le Scolan E,Jahchan N,Ji X,Xu A,Luo K

更新日期：2016-06-06 00:00:00

abstract：:What are the thermodynamic costs of development? In this issue of Developmental Cell, Rodenfels et al. (2019) demonstrate that the high energetic cost of coordinated cell division that is regulated by phospho-signaling gives rise to a measurable periodicity in the heat dissipated during zebrafish embryogenesis. ...

journal_title：Developmental cell

authors： Foster PJ,Razo-Mejia M,Phillips R

更新日期：2019-03-11 00:00:00

abstract：:Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation...

journal_title：Developmental cell

authors： Wang X,Kopinke D,Lin J,McPherson AD,Duncan RN,Otsuna H,Moro E,Hoshijima K,Grunwald DJ,Argenton F,Chien CB,Murtaugh LC,Dorsky RI

更新日期：2012-09-11 00:00:00