Abstract:
:Reporting in Cell, Berg et al. (2016) reveal a connection between genetic lysosomal storage disorders and the ability of macrophages to migrate and control mycobacterial infection. This insight, resulting from a zebrafish genetic screen, inspired the authors to propose an explanation for the increased susceptibility of cigarette smokers to tuberculosis.
journal_name
Dev Celljournal_title
Developmental cellauthors
Meijer AH,Aerts JMdoi
10.1016/j.devcel.2016.04.004subject
Has Abstractpub_date
2016-04-18 00:00:00pages
112-3issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(16)30199-Xjournal_volume
37pub_type
杂志文章,评审abstract::Regulation of microtubule organizing centers (MTOCs) orchestrates the reorganization of the microtubule (MT) cytoskeleton. In the fission yeast Schizosaccharomyces pombe, an equatorial MTOC (eMTOC) at the cell division site disassembles after cytokinesis, and multiple interphase MTOCs (iMTOCs) appear on the nucleus. H...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(04)00096-6
更新日期:2004-04-01 00:00:00
abstract::Renewing tissues have the remarkable ability to continually produce both proliferative progenitor and specialized differentiated cell types. How are complex milieus of microenvironmental signals interpreted to coordinate tissue-cell-type composition? Here, we investigate the responses of intestinal epithelium to indiv...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.12.020
更新日期:2021-01-15 00:00:00
abstract::BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell proliferation in the mouse intestine and skin. However, it remains unknown whether BMP signaling can promote self-renewal of adult somatic stem cells. In this study, we sh...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.09.013
更新日期:2005-11-01 00:00:00
abstract::Serrate (SE) is a key component in RNA metabolism. Little is known about whether and how it can regulate epigenetic silencing. Here, we report histone methyltransferases ATXR5 and ATXR6 (ATXR5/6) as novel partners of SE. ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formatio...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.05.023
更新日期:2018-06-18 00:00:00
abstract::Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.01.020
更新日期:2008-04-01 00:00:00
abstract::Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the bloodstream, reach distant organs, and locally modify the microenvironment. However, visualizing these events in vivo still faces major hurdles. Here...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.01.014
更新日期:2019-02-25 00:00:00
abstract::p120-catenin is an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. Despite recent advances in understanding the roles that p120-catenin and Kaiso play in downstream modulation of Wnt/beta-catenin signaling, the identity of t...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.09.022
更新日期:2006-11-01 00:00:00
abstract::Enhancers are the primary determinants of cell identity, but the regulatory components controlling enhancer turnover during lineage commitment remain largely unknown. Here we compare the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progeni...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.12.014
更新日期:2016-01-11 00:00:00
abstract::Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H₂O₂)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly w...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.12.007
更新日期:2011-02-15 00:00:00
abstract::Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively stud...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2017.09.018
更新日期:2017-11-20 00:00:00
abstract::Many human genes generate mRNAs with alternative 3' untranslated regions (3' UTRs), which can modulate protein function. In a recent Cell paper, Ma and Mayr (2018) unveil a major membraneless organelle, termed the TIS granule-endoplasmic reticulum (TIGER), which enables specific 3' UTRs to encipher protein localizatio...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2018.11.022
更新日期:2018-12-03 00:00:00
abstract::In this issue of Developmental Cell, Marhavý et al. (2011) uncover a transcription-independent molecular mechanism of interaction between auxin and cytokinin in the regulation of plant meristem function. By modulating endocytic trafficking of PIN1, cytokinin controls auxin flux and, therefore, auxin gradients. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2011.09.016
更新日期:2011-10-18 00:00:00
abstract::Dickkopf-1 (Dkk1) is a secreted Wnt antagonist with a well-established role in head induction during development. Numerous studies have emerged implicating Dkk1 in various malignancies and neurodegenerative diseases through an unknown mechanism. Using zebrafish gastrulation as a model for collective cell migration, we...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.10.026
更新日期:2019-12-16 00:00:00
abstract::The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell autonomously and nonautonomously. We demonstrate that these two activities of fz in planar polarity are temporally separable in both the eye and wing. The nonautonomous function is dishevelled (dsh...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00363-5
更新日期:2002-12-01 00:00:00
abstract::Transmission of the human parasite Brugia malayi relies on the sustained production of larvae in blood. In this issue of Developmental Cell,Foray et al. (2018) use methods developed in the model nematode C. elegans to reveal how a symbiotic bacterium supports the female germ cell development underlying this massive fe...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2018.04.006
更新日期:2018-04-23 00:00:00
abstract::A paper in the February issue of Molecular Cell describes the structure of the apoptosome, a multicomponent death machine, deciphered by cryoelectron microscopy. This structure explains the assembly of the machine, the tentative location of the subcomponents, and proposes a mechanism for initiating the death signal. ...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/s1534-5807(02)00137-5
更新日期:2002-03-01 00:00:00
abstract::We use the Dpp morphogen gradient in the Drosophila wing disc as a model to address the fundamental question of how a gradient of a growth factor can produce uniform growth. We first show that proper expression and subcellular localization of components in the Fat tumor-suppressor pathway, which have been argued to de...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.11.007
更新日期:2011-01-18 00:00:00
abstract::Recent studies have yielded a number of important insights into the mechanisms of hair follicle development and cycling and have highlighted the particularly important roles played by stem cells and Wnt signaling pathways. ...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/s1534-5807(01)00022-3
更新日期:2001-07-01 00:00:00
abstract::Despite their external bilateral symmetry, vertebrates have internal left/right (L/R) asymmetries required for optimal organ function. BMP-induced epithelial to mesenchymal transition (EMT) in the lateral plate mesoderm (LPM) triggers L/R asymmetric cell movements toward the midline, higher from the right, which are c...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.09.012
更新日期:2019-11-18 00:00:00
abstract::Multinucleate cells are widespread in nature, yet the mechanism by which cells fuse their plasma membranes is poorly understood. To identify animal fusogens, we performed new screens for mutations that abolish cell fusion within tissues of C. elegans throughout development. We identified the gene eff-1, which is expre...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00129-6
更新日期:2002-03-01 00:00:00
abstract::IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2012.10.025
更新日期:2012-11-13 00:00:00
abstract::Infectious, self-propagating protein aggregates (prions) as well as structurally related amyloid fibrils have traditionally been associated with neurodegenerative diseases in mammals. However, recent work in fungi indicates that prions are not simply aberrations of protein folding, but are in fact widespread, conserve...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/s1534-5807(02)00118-1
更新日期:2002-02-01 00:00:00
abstract::Apoptosis has been implicated in compensatory proliferation signaling (CPS), whereby dying cells induce proliferation in neighboring cells as a means to restore homeostasis. The nature of signaling between apoptotic cells and their neighboring cells remains largely unknown. Here we show that a fraction of apoptotic ce...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2017.05.014
更新日期:2017-06-19 00:00:00
abstract::Several genes are known to regulate circadian rhythms in Arabidopsis, but the identity of the central oscillator has not been established. LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved. Here we demonstrate that, as shown previously for CCA1, inactivation of LHY shortens the pe...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00170-3
更新日期:2002-05-01 00:00:00
abstract::The Drosophila compound eye consists of approximately 750 independently functioning ommatidia, each containing two photoreceptor subpopulations. The outer photoreceptors participate in motion detection, while the inner photoreceptors contribute to color vision. Although the inner photoreceptors, R7 and R8, terminally ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00156-4
更新日期:2003-06-01 00:00:00
abstract::We present new approaches to cis-regulatory module (CRM) discovery in the common scenario where relevant transcription factors and/or motifs are unknown. Beginning with a small list of CRMs mediating a common gene expression pattern, we search genome-wide for CRMs with similar functionality, using new statistical scor...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.09.002
更新日期:2009-10-01 00:00:00
abstract::MicroRNAs are important regulators of normal and malignant hematopoiesis. A paper by Lu et al. in this issue of Developmental Cell demonstrates how one microRNA, miR-150, plays a critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the widely expressed transcription factor M...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2008.05.011
更新日期:2008-06-01 00:00:00
abstract::Because mitochondria have outer and inner membranes, the fusion of two mitochondria requires the coordinated fusion of four lipid bilayers. Fusion of the outer membranes requires mitofusins. A new study published in Cell (Meeusen et al., 2006) shows that inner membrane fusion requires the dynamin-related protein Mgm1/...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.10.009
更新日期:2006-11-01 00:00:00
abstract::In yeast and animal cells, the sterol composition of membranes is a key factor that controls the polarity of membrane proteins by regulating their intracellular trafficking or lateral diffusion. A recent study in Nature Cell Biology demonstrates that plant sterols play a major role in the acquisition of cell polarity ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.02.007
更新日期:2008-03-01 00:00:00
abstract::The spinal cord and mesodermal tissues of the trunk such as the vertebral column and skeletal musculature derive from neuro-mesodermal progenitors (NMPs). Sox2, Brachyury (T), and Tbx6 have been correlated with NMP potency and lineage choice; however, their exact role and interaction in these processes have not yet be...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2017.07.021
更新日期:2017-09-11 00:00:00