Abstract:
:Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players.
journal_name
Dev Celljournal_title
Developmental cellauthors
Donaldson JGdoi
10.1016/s1534-5807(03)00298-3keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
527-8issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(03)00298-3journal_volume
5pub_type
杂志文章abstract::Dynamic rearrangements of the actin cytoskeleton play a key role in numerous cellular processes. In Drosophila, fusion between a muscle founder cell and a fusion competent myoblast (FCM) is mediated by an invasive, F-actin-enriched podosome-like structure (PLS). Here, we show that the dynamics of the PLS is controlled...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.04.007
更新日期:2011-05-17 00:00:00
abstract::Cells entering mitosis become rounded, lose attachment to the substrate, and increase their cortical rigidity. Pivotal to these events is the dismantling of focal adhesions (FAs). How mitotic reshaping is linked to commitment to divide is unclear. Here, we show that DEPDC1B, a protein that accumulates in G2, coordinat...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.09.009
更新日期:2014-11-24 00:00:00
abstract::Bazooka/Par-3 (Baz) is a key regulator of cell polarity in epithelial cells and neuroblasts (NBs). Phosphorylation of Baz by PAR-1 and aPKC is required for its function in epithelia, but little is known about the dephosphorylation mechanisms that antagonize the activities of these kinases or about the relevance of Baz...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.04.011
更新日期:2009-06-01 00:00:00
abstract::Embryonic organizers establish gradients of diffusible signaling molecules to pattern the surrounding cells. Here, we elucidate an additional mechanism of embryonic organizers that is a secondary consequence of morphogen signaling. Using pharmacological and localized transgenic perturbations, 4D imaging of the zebrafi...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.05.014
更新日期:2019-06-17 00:00:00
abstract::T-box genes encode DNA binding transcription factors known to regulate a wide variety of developmental processes during embryogenesis and are present in the genomes of all multicellular animals. Indeed, alongside other more familiar families of developmental regulators such as Hox, Sox, and Pax, T-box genes constitute...
journal_title:Developmental cell
pub_type:
doi:10.1016/s1534-5807(02)00330-1
更新日期:2002-11-01 00:00:00
abstract::Earlier, we reported that S6K1(-/-) mice have reduced body fat mass, have elevated rates of lipolysis, have severely decreased adipocyte size, and are resistant to high fat diet (HFD)-induced obesity. Here we report that adipocytes of S6K1(-/-) mice on a HFD have the capacity to increase in size to a degree comparable...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.02.018
更新日期:2010-05-18 00:00:00
abstract::Protein transport between the ER and the Golgi in mammalian cells occurs via large pleiomorphic carriers, and most current models suggest that these are formed by the fusion of small ER-derived COPII vesicles. We have examined the dynamics and structural features of these carriers during and after their formation from...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00294-6
更新日期:2003-10-01 00:00:00
abstract::Cell-to-cell communication coordinates the behavior of individual cells to establish organ patterning and development. Although mobile signals are known to be important in lateral root development, the role of plasmodesmata (PD)-mediated transport in this process has not been investigated. Here, we show that changes i...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.06.010
更新日期:2013-07-29 00:00:00
abstract::The ability of the death ligand TRAIL to induce tumor cell apoptosis has led to the development of TRAIL-based cancer therapies. Reporting recently in Molecular Cell, Lu et al. (2014) show that the basis for differential TRAIL responses involves clustering of death receptor complexes by E-cadherin and the actin cytosk...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2014.06.031
更新日期:2014-07-14 00:00:00
abstract::Recently reporting in Molecular Cell, Hussey et al. (2011) find that hnRNP E1 inhibits the translation of several genes essential for the epithelial-to-mesenchymal transition (EMT) by blocking eEF1A1 release during translation elongation. Phosphorylation of hnRNP E1 in response to TGF-β signaling disrupts the hnRNP E1...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2011.02.012
更新日期:2011-03-15 00:00:00
abstract::Optimal cell performance depends on cell size and the appropriate relative size, i.e., scaling, of the nucleus. How nuclear scaling is regulated and contributes to cell function is poorly understood, especially in skeletal muscle fibers, which are among the largest cells, containing hundreds of nuclei. Here, we presen...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.02.020
更新日期:2019-04-08 00:00:00
abstract::RITS (RNA-induced initiation of transcriptional gene silencing complex) plays diverse roles in heterochromatin regulation: silencing transcription by recruitment of chromatin modifiers and destroying transcripts by RNAi. In a recent issue of Molecular Cell, Li et al. now show that the polymerization of Tas3, a compone...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.05.002
更新日期:2009-05-01 00:00:00
abstract::Serrate (SE) is a key component in RNA metabolism. Little is known about whether and how it can regulate epigenetic silencing. Here, we report histone methyltransferases ATXR5 and ATXR6 (ATXR5/6) as novel partners of SE. ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formatio...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.05.023
更新日期:2018-06-18 00:00:00
abstract::A paper in the February issue of Molecular Cell describes the structure of the apoptosome, a multicomponent death machine, deciphered by cryoelectron microscopy. This structure explains the assembly of the machine, the tentative location of the subcomponents, and proposes a mechanism for initiating the death signal. ...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/s1534-5807(02)00137-5
更新日期:2002-03-01 00:00:00
abstract::The regulated release of polypeptides has a central role in physiology, behavior, and development, but the mechanisms responsible for production of the large dense core vesicles (LDCVs) capable of regulated release have remained poorly understood. Recent work has implicated cytosolic adaptor protein AP-3 in the recrui...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.10.007
更新日期:2013-11-25 00:00:00
abstract::Bacteria display an array of contact-dependent interaction systems that have evolved to facilitate direct cell-to-cell communication. We have previously identified a mode of bacterial communication mediated by nanotubes bridging neighboring cells. Here, we elucidate nanotube architecture, dynamics, and molecular compo...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.01.013
更新日期:2016-02-22 00:00:00
abstract::Hox proteins gain specificity by interacting with TALE-class cofactors. In a recent issue of Cell and in this issue of Developmental Cell, Crocker et al. (2015) and Amin et al. (2015), respectively, demonstrate that non-canonical Hox/TALE binding sequences play a major role in the regionalized regulation of target gen...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.01.030
更新日期:2015-02-09 00:00:00
abstract::By functioning as an enzyme cofactor, hemoglobin component, and gene regulator, heme is vital for life. One mode of heme-regulated transcription involves amplifying the activity of GATA-1, a key determinant of erythrocyte differentiation. To discover biological consequences of the metal cofactor-transcription factor m...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.07.022
更新日期:2018-09-10 00:00:00
abstract::The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds. ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.07.011
更新日期:2012-08-14 00:00:00
abstract::Wnt/β-catenin signaling plays critical roles during embryogenesis, tissue homeostasis, and regeneration. How Wnt-receptor complex activity is regulated is not yet fully understood. Here, we identify the Ly6 family protein LY6/PLAUR domain-containing 6 (Lypd6) as a positive feedback regulator of Wnt/β-catenin signaling...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.07.020
更新日期:2013-08-26 00:00:00
abstract::The cilia and cell cycles are inextricably linked. Centrioles in the basal body of cilia nucleate the ciliary axoneme and sequester pericentriolar matrix (PCM) at the centrosome to organize the mitotic spindle. Cilia themselves respond to growth signals, prompting cilia resorption and cell cycle re-entry. We describe ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.10.027
更新日期:2018-11-19 00:00:00
abstract::Although the mechanisms underlying the spatial pattern formation of sensory maps have been extensively investigated, those triggering sensory map formation during development are largely unknown. Here we show that the birth of pups instructively and selectively regulates the initiation of barrel formation in the somat...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.09.002
更新日期:2013-10-14 00:00:00
abstract::DNA crosslinking agents are commonly used in cancer chemotherapy; however, responses of normal tissues to these agents have not been widely investigated. We reveal in mouse interfollicular epidermal, mammary and hair follicle epithelia that genotoxicity does not promote apoptosis but paradoxically induces hyperplasia ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.09.021
更新日期:2020-12-07 00:00:00
abstract::Cytoplasmic dynein-1 is a minus-end-directed motor protein that transports cargo over long distances and organizes the intracellular microtubule (MT) network. How dynein motor activity is harnessed for these diverse functions remains unknown. Here, we have uncovered a mechanism for how processive dynein-dynactin compl...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2017.12.023
更新日期:2018-01-22 00:00:00
abstract::High-molecular-weight hyaluronan, a major component of the extracellular matrix, is anti-oncogenic, whereas low-molecular-weight hyaluronan is pro-oncogenic, though the mechanisms underlying the size-dependent opposite bioactivities of hyaluronan remain uncertain. We show here that treatment with high-molecular-weight...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.04.018
更新日期:2019-05-20 00:00:00
abstract::Regulated turnover of integrin receptors is essential for cell adhesion and migration. Pathways selectively regulating β1-integrin recycling are implicated in cancer invasion and metastasis, yet proteins required for the internalization of this pro-invasive integrin remain to be identified. Here, we uncover formin-lik...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.06.015
更新日期:2015-08-24 00:00:00
abstract::Polarized delivery of signaling and adhesion molecules to the leading edge is required for directional migration of cells. Here, we describe a role for the PIP(2)-synthesizing enzyme, PIPKIγi2, in regulation of exocyst complex control of cell polarity and polarized integrin trafficking during migration. Loss of PIPKIγ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.10.030
更新日期:2012-01-17 00:00:00
abstract::The adaptor complex AP-2 plays an important role in cargo selection and clathrin lattice formation during clathrin-mediated endocytosis. In a recent issue of Molecular Cell, Honing et al. demonstrate that high-affinity AP-2 membrane association is achieved through a combination of low-affinity interactions with membra...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.05.013
更新日期:2005-06-01 00:00:00
abstract::TGF-beta superfamily signaling pathways emerged with the evolution of multicellular animals, suggesting that these pathways contribute to the increased diversity and complexity required for the development and homeostasis of these organisms. In this review we begin by exploring some key developmental and disease proce...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2009.02.012
更新日期:2009-03-01 00:00:00
abstract::Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA synthesis phase. Cyclin E expression is normally restricted to proliferating cells. However, high levels of cyclin E are expressed in the adult brain. The function of ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.08.009
更新日期:2011-10-18 00:00:00