Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle.

abstract：:Cell locomotion entails functional and structural cooperation between cell surface adhesion and the actin cytoskeleton. A new paper by DeMali et al. provides new insights into the link between actin assembly and integrin adhesion at the leading edges of migrating cells. ...

journal_title：Developmental cell

authors： Kovacs EM,Yap AS

更新日期：2002-12-01 00:00:00

abstract：:Multinucleate cells are widespread in nature, yet the mechanism by which cells fuse their plasma membranes is poorly understood. To identify animal fusogens, we performed new screens for mutations that abolish cell fusion within tissues of C. elegans throughout development. We identified the gene eff-1, which is expre...

journal_title：Developmental cell

authors： Mohler WA,Shemer G,del Campo JJ,Valansi C,Opoku-Serebuoh E,Scranton V,Assaf N,White JG,Podbilewicz B

更新日期：2002-03-01 00:00:00

abstract：:DNA crosslinking agents are commonly used in cancer chemotherapy; however, responses of normal tissues to these agents have not been widely investigated. We reveal in mouse interfollicular epidermal, mammary and hair follicle epithelia that genotoxicity does not promote apoptosis but paradoxically induces hyperplasia ...

journal_title：Developmental cell

authors： Seldin L,Macara IG

更新日期：2020-12-07 00:00:00

abstract：:Efficient regeneration following injury is critical for maintaining tissue function and enabling organismal survival. Cells reconstituting damaged tissue are often generated from resident stem or progenitor cells or from cells that have dedifferentiated and become proliferative. While lineage-tracing studies have defi...

journal_title：Developmental cell

authors： Iyengar S,Kasheta M,Ceol CJ

更新日期：2015-06-22 00:00:00

abstract：:The regulated release of polypeptides has a central role in physiology, behavior, and development, but the mechanisms responsible for production of the large dense core vesicles (LDCVs) capable of regulated release have remained poorly understood. Recent work has implicated cytosolic adaptor protein AP-3 in the recrui...

journal_title：Developmental cell

authors： Asensio CS,Sirkis DW,Maas JW Jr,Egami K,To TL,Brodsky FM,Shu X,Cheng Y,Edwards RH

更新日期：2013-11-25 00:00:00

abstract：:Translation of ribosomal protein-coding mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in coordination with other cellular processes are poorly defined. Here, we show that subcellular localization of RP-mRNAs acts as a key regulator of their transla...

journal_title：Developmental cell

authors： Dermit M,Dodel M,Lee FCY,Azman MS,Schwenzer H,Jones JL,Blagden SP,Ule J,Mardakheh FK

更新日期：2020-11-09 00:00:00

abstract：:Eukaryotic genomes are organized within the nucleus through interactions with inner nuclear membrane (INM) proteins. How chromatin tethering to the INM is controlled in interphase and how this process contributes to subsequent mitotic nuclear envelope (NE) remodeling remains unclear. We have probed these fundamental q...

journal_title：Developmental cell

authors： Pieper GH,Sprenger S,Teis D,Oliferenko S

更新日期：2020-04-06 00:00:00

abstract：:Fission yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic inducer Mei2 and the transcription factor Ste11. Here, we show how Pat1 downregulates these proteins. Mei2 is degraded via a ubiquitin-proteasome pathway in a phosphorylation-dependent fashion. The E2 Ubc2 and the E3 Ubr1 are requ...

journal_title：Developmental cell

authors： Kitamura K,Katayama S,Dhut S,Sato M,Watanabe Y,Yamamoto M,Toda T

更新日期：2001-09-01 00:00:00

abstract：:In eukaryotes, small RNAs (sRNAs) have key roles in development, gene expression regulation, and genome integrity maintenance. In ciliates, such as Paramecium, sRNAs form the heart of an epigenetic system that has evolved from core eukaryotic gene silencing components to selectively target DNA for deletion. In Paramec...

journal_title：Developmental cell

authors： Sandoval PY,Swart EC,Arambasic M,Nowacki M

更新日期：2014-01-27 00:00:00

abstract：:Ribosomes perform protein synthesis but are also involved in signaling processes, the full extent of which are still being uncovered. We report that phenotypes of mutating ribosomal proteins (Rps) are largely due to signaling. Using Drosophila, we discovered that a bZip-domain protein, Xrp1, becomes elevated in Rp mut...

journal_title：Developmental cell

authors： Lee CH,Kiparaki M,Blanco J,Folgado V,Ji Z,Kumar A,Rimesso G,Baker NE

更新日期：2018-08-20 00:00:00

abstract：:Plants assemble beneficial root-associated microbiomes to support growth, especially in nutrient-poor conditions. To do so, however, plants have to suppress their immune system. Reporting in Nature, Castrillo et al. (2017) identified PHOSPHATE STARVATION RESPONSE1 (PHR1) as a central regulator in this balance between ...

journal_title：Developmental cell

authors： Motte H,Beeckman T

更新日期：2017-04-10 00:00:00

abstract：:Septins are polymerizing GTP binding proteins required for cortical organization during cytokinesis and other cellular processes. A mammalian septin gene Sept4 is expressed mainly in postmitotic neural cells and postmeiotic male germ cells. In mouse and human spermatozoa, SEPT4 and other septins are found in the annul...

journal_title：Developmental cell

authors： Ihara M,Kinoshita A,Yamada S,Tanaka H,Tanigaki A,Kitano A,Goto M,Okubo K,Nishiyama H,Ogawa O,Takahashi C,Itohara S,Nishimune Y,Noda M,Kinoshita M

更新日期：2005-03-01 00:00:00

abstract：:The vertebral column derives from somites generated by segmentation of presomitic mesoderm (PSM). Somitogenesis involves a molecular oscillator, the segmentation clock, controlling periodic Notch signaling in the PSM. Here, we establish a novel link between Wnt/beta-catenin signaling and the segmentation clock. Axin2,...

journal_title：Developmental cell

authors： Aulehla A,Wehrle C,Brand-Saberi B,Kemler R,Gossler A,Kanzler B,Herrmann BG

更新日期：2003-03-01 00:00:00

abstract：:We developed a comprehensive dataset that samples the mouse transcriptome every 6 hr, from gastrulation through organogenesis. We observe an abrupt increase in overall transcript diversity at the onset of organogenesis (e8.0); the genes that comprise these changes are preferentially clustered along chromosome 7 and co...

journal_title：Developmental cell

authors： Mitiku N,Baker JC

更新日期：2007-12-01 00:00:00

abstract：:In this issue of Developmental Cell, Weavers and Skaer (2013) show that interplay between two opposing forces generated by tip cell attachment to muscles and migration of kink cells allows for the formation of the looped shape and positioning of renal tubules within the body of a fly larva. ...

journal_title：Developmental cell

authors： Lenard A,Affolter M

更新日期：2013-11-11 00:00:00

abstract：:Our vasculature plays diverse and critical roles in homeostasis and disease. In recent decades, the use of zebrafish has driven our understanding of vascular development into new areas, identifying new genes and mechanisms controlling vessel formation and allowing unprecedented observation of the cellular and molecula...

journal_title：Developmental cell

authors： Hogan BM,Schulte-Merker S

更新日期：2017-09-25 00:00:00

abstract：:Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characterization of the facto...

journal_title：Developmental cell

authors： Symmons O,Pan L,Remeseiro S,Aktas T,Klein F,Huber W,Spitz F

更新日期：2016-12-05 00:00:00

abstract：:The advent of reprogramming and its impact on stem cell biology has renewed interest in lineage restriction in mammalian embryos, the source of embryonic (ES), epiblast (EpiSC), trophoblast (TS), and extraembryonic endoderm (XEN) stem cell lineages. Isolation of specific cell types during stem cell differentiation and...

journal_title：Developmental cell

authors： Rugg-Gunn PJ,Cox BJ,Lanner F,Sharma P,Ignatchenko V,McDonald AC,Garner J,Gramolini AO,Rossant J,Kislinger T

更新日期：2012-04-17 00:00:00

abstract：:The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLA...

journal_title：Developmental cell

authors： González Montoro A,Auffarth K,Hönscher C,Bohnert M,Becker T,Warscheid B,Reggiori F,van der Laan M,Fröhlich F,Ungermann C

更新日期：2018-06-04 00:00:00

abstract：:In this issue of Developmental Cell, Tang et al. (2018) and Li et al. (2018) combine genetic manipulation, mechanical perturbation, and live imaging to show how mechanical forces and local growth factors intersect to influence epithelial behavior and cell fate specification within the developing lung. ...

journal_title：Developmental cell

authors： Hogan BLM

更新日期：2018-02-05 00:00:00

abstract：:Although autophagy is being pursued as a therapeutic target in clinical oncology trials, its effects on metastasis, the principal cause of cancer mortality, remain unclear. Here, we utilize mammary cancer models to temporally delete essential autophagy regulators during carcinoma progression. Though genetic ablation o...

journal_title：Developmental cell

authors： Marsh T,Kenific CM,Suresh D,Gonzalez H,Shamir ER,Mei W,Tankka A,Leidal AM,Kalavacherla S,Woo K,Werb Z,Debnath J

更新日期：2020-03-09 00:00:00

abstract：:The dorsoventral axis of the Drosophila embryo is patterned by a gradient of bone morphogenetic protein (BMP) ligands. In a process requiring at least three additional extracellular proteins, a broad domain of weak signaling forms and then abruptly sharpens into a narrow dorsal midline peak. Using experimental and com...

journal_title：Developmental cell

authors： Mizutani CM,Nie Q,Wan FY,Zhang YT,Vilmos P,Sousa-Neves R,Bier E,Marsh JL,Lander AD

更新日期：2005-06-01 00:00:00

abstract：:Polarity is a prominent feature of both chemotaxis and cytokinesis. In chemotaxis, polarity is established by local accumulation of PI(3,4,5)P3 at the cell's leading edge, achieved through temporal and spatial regulation of PI3 kinases and the tumor suppressor, PTEN. We find that as migrating D. discoideum cells round...

journal_title：Developmental cell

authors： Janetopoulos C,Borleis J,Vazquez F,Iijima M,Devreotes P

更新日期：2005-04-01 00:00:00

abstract：:Metastasizing breast carcinoma cells have been hypothesized to mobilize tissue-invasive activity by co-opting the proteolytic systems employed by normal mammary epithelial cells undergoing branching morphogenesis. However, the critical effectors underlying morphogenesis remain unidentified, and their relationship to b...

journal_title：Developmental cell

authors： Feinberg TY,Zheng H,Liu R,Wicha MS,Yu SM,Weiss SJ

更新日期：2018-10-22 00:00:00

abstract：:During development, primordial germ cells (PGCs) navigate a complex journey to generate the germline. In a recent paper in Nature Cell Biology, Nance and colleagues (Abdu et al., 2016) have discovered an unexpected step along the way: PGCs get cut in half by endodermal cells. ...

journal_title：Developmental cell

authors： Krishna S,Overholtzer M

更新日期：2016-12-19 00:00:00

abstract：:One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an ant...

journal_title：Developmental cell

authors： Dos Santos A,Elowe S

更新日期：2020-12-21 00:00:00

abstract：:Theoretical modeling is central to elucidating underlying principles of emergent properties of complex systems. In cell and developmental biology, the last 15 years have witnessed a convergence of empirical and modeling approaches for fresh perspectives. The role of cell division in coordinating size, shape, and fate ...

journal_title：Developmental cell

authors： Bellaïche Y

更新日期：2016-09-26 00:00:00

abstract：:Embryonic development of the liver has been studied intensely, yielding insights that impact diverse areas of developmental and cell biology. Understanding the fundamental mechanisms that control hepatogenesis has also laid the basis for the rational differentiation of stem cells into cells that display many hepatic f...

journal_title：Developmental cell

authors： Si-Tayeb K,Lemaigre FP,Duncan SA

更新日期：2010-02-16 00:00:00

abstract：:Mammary epithelial phagocytosis is critical for removal of apoptotic cells during involution, but the mechanisms governing this process are largely unknown. In this issue of Developmental Cell, Akhtar et al. (2016) provide insight into mechanisms regulating involution, demonstrating that Rac1 drives the switch from di...

journal_title：Developmental cell

authors： Naylor MJ

更新日期：2016-09-12 00:00:00

abstract：:The function of local protein synthesis in synaptic plasticity and its dysregulation in fragile X syndrome (FXS) is well studied, however the contribution of regulated mRNA transport to this function remains unclear. We report a function for the fragile X mental retardation protein (FMRP) in the rapid, activity-regula...

journal_title：Developmental cell

authors： Dictenberg JB,Swanger SA,Antar LN,Singer RH,Bassell GJ

更新日期：2008-06-01 00:00:00