当前位置： SCI文献检索 > DEVELOPMENTAL CELL期刊下所有文献 > Intron Retained, Transcript Detained: Intron Retention as a Hallmark of the Quiescent Satellite Cell State.

Intron Retained, Transcript Detained: Intron Retention as a Hallmark of the Quiescent Satellite Cell State.

Abstract：

:Molecular signatures defining quiescence in muscle satellite cells (mSCs) remain enigmatic. In this issue of Developmental Cell, Yue et al. adapted an in vivo fixation approach to isolate dormant mSCs from healthy muscle. Characterizing the transcriptome from these cells, they identified intron retention as a novel hallmark of mSC quiescence.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Nakka K,Kovac R,Wong MM,Dilworth FJ

doi

10.1016/j.devcel.2020.05.028

subject

Has Abstract

pub_date

2020-06-22 00:00:00

pages

623-625

issue

6

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(20)30417-2

journal_volume

53

pub_type

评论,杂志文章

相关文献

DEVELOPMENTAL CELL文献大全
  • Filopodia: the cellular quills of hedgehog signaling?

    abstract：:Reporting in Nature, Sanders et al. (2013) implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb. Actin-based filopodia transport Shh from producing cells, while filopodia of responding cells bear Cdon and Boc: coreceptors in the Shh pathway. These findings suggest a new mechanism of ligand m...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2013.05.008

    authors： McMahon AP,Hasso SM

    更新日期：2013-05-28 00:00:00

  • Hedgehog signaling is a principal inducer of Myosin-II-driven cell ingression in Drosophila epithelia.

    abstract：:Cell constriction promotes epithelial sheet invagination during embryogenesis across phyla. However, how this cell response is linked to global patterning information during organogenesis remains unclear. To address this issue, we have used the Drosophila eye and studied the formation of the morphogenetic furrow (MF),...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2007.09.015

    authors： Corrigall D,Walther RF,Rodriguez L,Fichelson P,Pichaud F

    更新日期：2007-11-01 00:00:00

  • Cilia Control Fat Deposition during Tissue Repair.

    abstract：:Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2017.06.023

    authors： Perdiguero E,Serrano AL,Muñoz-Cánoves P

    更新日期：2017-07-24 00:00:00

  • A molecular base for cell sorting at embryonic boundaries: contact inhibition of cadherin adhesion by ephrin/ Eph-dependent contractility.

    abstract：:The mechanism responsible for subdividing the embryo into individual tissues is a fundamental, yet still poorly understood, question in developmental biology. Various general hypotheses have been proposed, involving differences in cell adhesion, contractility, or contact-mediated repulsion. However, the key parameter ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2013.09.004

    authors： Fagotto F,Rohani N,Touret AS,Li R

    更新日期：2013-10-14 00:00:00

  • Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis.

    abstract：:The identities of the ubiquitin-ligases active during myogenesis are largely unknown. Here we describe a RING-type E3 ligase complex specified by the adaptor protein, Ozz, a novel SOCS protein that is developmentally regulated and expressed exclusively in striated muscle. In mice, the absence of Ozz results in overt m...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(04)00020-6

    authors： Nastasi T,Bongiovanni A,Campos Y,Mann L,Toy JN,Bostrom J,Rottier R,Hahn C,Conaway JW,Harris AJ,D'Azzo A

    更新日期：2004-02-01 00:00:00

  • Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation.

    abstract：:CLIPs are microtubule plus end-associated proteins that mediate interactions required for cell polarity and cell division. Here we demonstrate that budding yeast Bik1, unlike its human ortholog CLIP-170, is targeted to the microtubule plus end by a kinesin-dependent transport mechanism. Bik1 forms a complex with the k...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2004.05.001

    authors： Carvalho P,Gupta ML Jr,Hoyt MA,Pellman D

    更新日期：2004-06-01 00:00:00

  • Role of lipid metabolism in smoothened derepression in hedgehog signaling.

    abstract：:The binding of Hedgehog (Hh) to its receptor Patched causes derepression of Smoothened (Smo), resulting in the activation of the Hh pathway. Here, we show that Smo activation is dependent on the levels of the phospholipid phosphatidylinositol-4 phosphate (PI4P). Loss of STT4 kinase, which is required for the generatio...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2010.06.007

    authors： Yavari A,Nagaraj R,Owusu-Ansah E,Folick A,Ngo K,Hillman T,Call G,Rohatgi R,Scott MP,Banerjee U

    更新日期：2010-07-20 00:00:00

  • Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs.

    abstract：:Metastasizing breast carcinoma cells have been hypothesized to mobilize tissue-invasive activity by co-opting the proteolytic systems employed by normal mammary epithelial cells undergoing branching morphogenesis. However, the critical effectors underlying morphogenesis remain unidentified, and their relationship to b...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2018.08.025

    authors： Feinberg TY,Zheng H,Liu R,Wicha MS,Yu SM,Weiss SJ

    更新日期：2018-10-22 00:00:00

  • Hedgehog signaling in development and cancer.

    abstract：:The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signalin...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.devcel.2008.11.010

    authors： Jiang J,Hui CC

    更新日期：2008-12-01 00:00:00

  • IRE1, a double-edged sword in pre-miRNA slicing and cell death.

    abstract：:IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2012.10.025

    authors： Hassler J,Cao SS,Kaufman RJ

    更新日期：2012-11-13 00:00:00

  • Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites.

    abstract：:The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLA...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2018.05.011

    authors： González Montoro A,Auffarth K,Hönscher C,Bohnert M,Becker T,Warscheid B,Reggiori F,van der Laan M,Fröhlich F,Ungermann C

    更新日期：2018-06-04 00:00:00

  • Probing intrinsic properties of a robust morphogen gradient in Drosophila.

    abstract：:A remarkable feature of development is its reproducibility, the ability to correct embryo-to-embryo variations and instruct precise patterning. In Drosophila, embryonic patterning along the anterior-posterior axis is controlled by the morphogen gradient Bicoid (Bcd). In this article, we describe quantitative studies o...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2008.09.004

    authors： He F,Wen Y,Deng J,Lin X,Lu LJ,Jiao R,Ma J

    更新日期：2008-10-01 00:00:00

  • Less Is More: Ditching Mitochondria Saves Hypoxic Cartilage.

    abstract：:In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2019.05.030

    authors： Long F

    更新日期：2019-06-03 00:00:00

  • A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.

    abstract：:The cilia and cell cycles are inextricably linked. Centrioles in the basal body of cilia nucleate the ciliary axoneme and sequester pericentriolar matrix (PCM) at the centrosome to organize the mitotic spindle. Cilia themselves respond to growth signals, prompting cilia resorption and cell cycle re-entry. We describe ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2018.10.027

    authors： Ford MJ,Yeyati PL,Mali GR,Keighren MA,Waddell SH,Mjoseng HK,Douglas AT,Hall EA,Sakaue-Sawano A,Miyawaki A,Meehan RR,Boulter L,Jackson IJ,Mill P,Mort RL

    更新日期：2018-11-19 00:00:00

  • The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C.

    abstract：:One G protein-coupled receptor (GPCR) can activate more than one G protein, but the physiologic importance of such activation has not been demonstrated in vivo. We have generated mice expressing exclusively a mutant form of the PTH/PTHrP receptor (DSEL) that activates adenylyl cyclase normally but not phospholipase C ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(02)00218-6

    authors： Guo J,Chung UI,Kondo H,Bringhurst FR,Kronenberg HM

    更新日期：2002-08-01 00:00:00

  • A Transcriptional Lineage of the Early C. elegans Embryo.

    abstract：:During embryonic development, cells must establish fates, morphologies, and behaviors in coordination with one another to form a functional body. A prevalent hypothesis for how this coordination is achieved is that each cell's fate and behavior is determined by a defined mixture of RNAs. Only recently has it become po...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2016.07.025

    authors： Tintori SC,Osborne Nishimura E,Golden P,Lieb JD,Goldstein B

    更新日期：2016-08-22 00:00:00

  • Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiation via ubiquitin proteolysis and 14-3-3 protein in fission yeast.

    abstract：:Fission yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic inducer Mei2 and the transcription factor Ste11. Here, we show how Pat1 downregulates these proteins. Mei2 is degraded via a ubiquitin-proteasome pathway in a phosphorylation-dependent fashion. The E2 Ubc2 and the E3 Ubr1 are requ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(01)00037-5

    authors： Kitamura K,Katayama S,Dhut S,Sato M,Watanabe Y,Yamamoto M,Toda T

    更新日期：2001-09-01 00:00:00

  • Tugging organs into place.

    abstract：:In this issue of Developmental Cell, Weavers and Skaer (2013) show that interplay between two opposing forces generated by tip cell attachment to muscles and migration of kink cells allows for the formation of the looped shape and positioning of renal tubules within the body of a fly larva. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2013.10.021

    authors： Lenard A,Affolter M

    更新日期：2013-11-11 00:00:00

  • Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression.

    abstract：:Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in regulation of both the Hippo-Yap and Rac1-Pak1 pathways. Using genetically engineered murine liver models, we show that co-deletion of Rac1 with Nf2 blocks tumor initiation but paradoxically exacerbates hepatomegaly induced by N...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2016.09.027

    authors： Shi Y,Bollam SR,White SM,Laughlin SZ,Graham GT,Wadhwa M,Chen H,Nguyen C,Vitte J,Giovannini M,Toretsky J,Yi C

    更新日期：2016-11-21 00:00:00

  • HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes.

    abstract：:Transcriptional mediators of cell stress pathways, including HIF1α, ATF4, and p53, are key to normal development and play critical roles in disease, including ischemia and cancer. Despite their importance, mechanisms by which pathways mediated by these transcription factors interact with one another are not fully unde...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2015.04.021

    authors： Guimarães-Camboa N,Stowe J,Aneas I,Sakabe N,Cattaneo P,Henderson L,Kilberg MS,Johnson RS,Chen J,McCulloch AD,Nobrega MA,Evans SM,Zambon AC

    更新日期：2015-06-08 00:00:00

  • Do morphogen gradients arise by diffusion?

    abstract：:Many patterns of cell and tissue organization are specified during development by gradients of morphogens, substances that assign different cell fates at different concentrations. Gradients form by morphogen transport from a localized site, but whether this occurs by simple diffusion or by more elaborate mechanisms is...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(02)00179-x

    authors： Lander AD,Nie Q,Wan FY

    更新日期：2002-06-01 00:00:00

  • Wnt3a plays a major role in the segmentation clock controlling somitogenesis.

    abstract：:The vertebral column derives from somites generated by segmentation of presomitic mesoderm (PSM). Somitogenesis involves a molecular oscillator, the segmentation clock, controlling periodic Notch signaling in the PSM. Here, we establish a novel link between Wnt/beta-catenin signaling and the segmentation clock. Axin2,...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(03)00055-8

    authors： Aulehla A,Wehrle C,Brand-Saberi B,Kemler R,Gossler A,Kanzler B,Herrmann BG

    更新日期：2003-03-01 00:00:00

  • Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal.

    abstract：:Large intergenic noncoding (linc) RNAs constitute a new dimension of posttranscriptional gene regulation. In this issue of Developmental Cell, Wang et al. (2013) find that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to trap miR-145, thus regulating core pluripotency factors Oct...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2013.03.020

    authors： Cheng EC,Lin H

    更新日期：2013-04-15 00:00:00

  • Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR.

    abstract：:Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.devcel.2017.09.020

    authors： Ewen-Campen B,Mohr SE,Hu Y,Perrimon N

    更新日期：2017-10-09 00:00:00

  • Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.

    abstract：:Metazoans express three unfolded protein response transducers (IRE1, PERK, and ATF6) ubiquitously to cope with endoplasmic reticulum (ER) stress. ATF6 is an ER membrane-bound transcription factor activated by ER stress-induced proteolysis and has been duplicated in mammals. Here, we generated ATF6alpha- and ATF6beta-k...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2007.07.018

    authors： Yamamoto K,Sato T,Matsui T,Sato M,Okada T,Yoshida H,Harada A,Mori K

    更新日期：2007-09-01 00:00:00

  • Reconsidering the Passive Diffusion Model of Steroid Hormone Cellular Entry.

    abstract：:Steroid hormones have long been thought to enter target cells via passive diffusion through the plasma membrane. Now, reporting in Developmental Cell, Okamoto et al. (2018) demonstrate that, at least for Drosophila, steroid hormones require a protein transporter for cellular entry. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2018.10.022

    authors： Neuman SD,Bashirullah A

    更新日期：2018-11-05 00:00:00

  • HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.

    abstract：:The genetic networks that govern vertebrate development are well studied, but how the interactions of trans-acting factors with cis-regulatory modules (CRMs) are integrated into spatiotemporal regulation of gene expression is not clear. The transcriptional regulator HAND2 is required during limb, heart, and branchial ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2014.09.018

    authors： Osterwalder M,Speziale D,Shoukry M,Mohan R,Ivanek R,Kohler M,Beisel C,Wen X,Scales SJ,Christoffels VM,Visel A,Lopez-Rios J,Zeller R

    更新日期：2014-11-10 00:00:00

  • Distinction between color photoreceptor cell fates is controlled by Prospero in Drosophila.

    abstract：:The Drosophila compound eye consists of approximately 750 independently functioning ommatidia, each containing two photoreceptor subpopulations. The outer photoreceptors participate in motion detection, while the inner photoreceptors contribute to color vision. Although the inner photoreceptors, R7 and R8, terminally ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(03)00156-4

    authors： Cook T,Pichaud F,Sonneville R,Papatsenko D,Desplan C

    更新日期：2003-06-01 00:00:00

  • Global analysis of the meiotic crossover landscape.

    abstract：:Tight control of the number and distribution of crossovers is of great importance for meiosis. Crossovers establish chiasmata, which are physical connections between homologous chromosomes that provide the tension necessary to align chromosomes on the meiotic spindle. Understanding the mechanisms underlying crossover ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2008.07.006

    authors： Chen SY,Tsubouchi T,Rockmill B,Sandler JS,Richards DR,Vader G,Hochwagen A,Roeder GS,Fung JC

    更新日期：2008-09-01 00:00:00

  • The CKI1 Histidine Kinase Specifies the Female Gametic Precursor of the Endosperm.

    abstract：:Since the discovery of double fertilization, it has been recognized that flowering plants produce two highly dimorphic female gametes, the egg cell and central cell. These give rise, respectively, to the embryo and the endosperm, a nourishing tissue unique to flowering plants. Here we show that in Arabidopsis, endospe...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2016.03.009

    authors： Yuan L,Liu Z,Song X,Johnson C,Yu X,Sundaresan V

    更新日期：2016-04-04 00:00:00