Abstract:
:Cell constriction promotes epithelial sheet invagination during embryogenesis across phyla. However, how this cell response is linked to global patterning information during organogenesis remains unclear. To address this issue, we have used the Drosophila eye and studied the formation of the morphogenetic furrow (MF), which is characterized by cells undergoing a synchronous apical constriction and apicobasal contraction. We show that this cell response relies on microtubules and F-actin enrichment within the apical domain of the constricting cell as well as on the activation of nonmuscle myosin. In the MF, Hedgehog (Hh) signaling is required to promote cell constriction downstream of cubitus interruptus (ci), and, in this context, Ci155 functions redundantly with mad, the main effector of dpp/BMP signaling. Furthermore, ectopically activating Hh signaling in fly epithelia reveals a direct relationship between the duration of exposure to this signaling pathway, the accumulation of activated Myosin II, and the degree of tissue invagination.
journal_name
Dev Celljournal_title
Developmental cellauthors
Corrigall D,Walther RF,Rodriguez L,Fichelson P,Pichaud Fdoi
10.1016/j.devcel.2007.09.015subject
Has Abstractpub_date
2007-11-01 00:00:00pages
730-42issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(07)00356-5journal_volume
13pub_type
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