Abstract:
:Sox2 expression marks neural and sensory primordia at various stages of development. A 50 kb genomic region of chicken Sox2 was isolated and scanned for enhancer activity utilizing embryo electroporation, resulting in identification of a battery of enhancers. Although Sox2 expression in the early embryonic CNS appears uniform, it is actually pieced together by five separate enhancers with distinct spatio-temporal specificities, including the one activated by the neural induction signals emanating from Hensen's node. Enhancers for Sox2 expression in the lens and nasal/otic placodes and in the neural crest were also determined. These functionally identified Sox2 enhancers exactly correspond to the extragenic sequence blocks conspicuously conserved between chicken and mammals, which are not discernible by sequence comparison among mammals.
journal_name
Dev Celljournal_title
Developmental cellauthors
Uchikawa M,Ishida Y,Takemoto T,Kamachi Y,Kondoh Hdoi
10.1016/s1534-5807(03)00088-1keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
509-19issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(03)00088-1journal_volume
4pub_type
杂志文章abstract::Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al.(2007) present evidence to indicate that Chk1 als...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2007.01.005
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abstract::Migrating fibroblasts undergo contact inhibition of locomotion (CIL), a process that was discovered five decades ago and still is not fully understood at the molecular level. We identify the Slit2-Robo4-srGAP2 signaling network as a key regulator of CIL in fibroblasts. CIL involves highly dynamic contact protrusions w...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.09.002
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abstract::Bazooka/Par-3 (Baz) is a key regulator of cell polarity in epithelial cells and neuroblasts (NBs). Phosphorylation of Baz by PAR-1 and aPKC is required for its function in epithelia, but little is known about the dephosphorylation mechanisms that antagonize the activities of these kinases or about the relevance of Baz...
journal_title:Developmental cell
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doi:10.1016/j.devcel.2009.04.011
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abstract::How adherens junctions (AJs) are formed upon cell division is largely unexplored. Here, we found that AJ formation is coordinated with cytokinesis and relies on an interplay between the dividing cell and its neighbors. During contraction of the cytokinetic ring, the neighboring cells locally accumulate Myosin II and p...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.11.019
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abstract::Apoptosis has been implicated in compensatory proliferation signaling (CPS), whereby dying cells induce proliferation in neighboring cells as a means to restore homeostasis. The nature of signaling between apoptotic cells and their neighboring cells remains largely unknown. Here we show that a fraction of apoptotic ce...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2017.05.014
更新日期:2017-06-19 00:00:00
abstract::What coordinates the internal leading and trailing edges in collectively migrating cells is largely unknown. In this issue of Developmental Cell, Barlan et al. (2017) delineate a Fat2/Lar planar signaling pathway at the basal, motile cell-cell contacts of Drosophila egg chamber follicle cells. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2017.02.025
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abstract::Changes to cell shape and interaction drive animal tissue morphogenesis. Reporting now in Developmental Cell, Del Signore et al. (2018) describe active lengthening of cell-cell contacts by Arp2/3-based actin networks. Through cycles of contact lengthening and shortening, the developing Drosophila eye passes through va...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2018.02.003
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.08.008
更新日期:2010-09-14 00:00:00
abstract::The large GTPase Dynamin 2 (Dyn2) is markedly upregulated in pancreatic cancer, is a potent activator of metastatic migration, and is required for Rac1-mediated formation of lamellipodia. Here we demonstrate an unexpected mechanism of Dyn2 action in these contexts via direct binding to the Rac1 guanine nucleotide exch...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.02.010
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.03.017
更新日期:2019-04-22 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.06.009
更新日期:2007-08-01 00:00:00
abstract::While autophagy is thought to be an essential process in some cancer cells, it is unknown if or how such cancer cells can circumvent autophagy inhibition. To address this, we developed a CRISPR/Cas9 assay with dynamic live-cell imaging to measure acute effects of knockout (KO) of autophagy genes compared to known esse...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.07.010
更新日期:2019-09-23 00:00:00
abstract::The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell autonomously and nonautonomously. We demonstrate that these two activities of fz in planar polarity are temporally separable in both the eye and wing. The nonautonomous function is dishevelled (dsh...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00363-5
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abstract::Plants assemble beneficial root-associated microbiomes to support growth, especially in nutrient-poor conditions. To do so, however, plants have to suppress their immune system. Reporting in Nature, Castrillo et al. (2017) identified PHOSPHATE STARVATION RESPONSE1 (PHR1) as a central regulator in this balance between ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2017.03.019
更新日期:2017-04-10 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00259-9
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.03.009
更新日期:2016-04-04 00:00:00
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journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2016.08.016
更新日期:2016-09-12 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2021.01.002
更新日期:2021-01-25 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.04.009
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.05.010
更新日期:2010-06-15 00:00:00
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journal_title:Developmental cell
pub_type: 评论,杂志文章
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journal_title:Developmental cell
pub_type: 杂志文章
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journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2004.07.014
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abstract::Neuroblastomas are associated with KIF1Bβ mutations within tumor suppressor region 1p36. In this issue of Developmental Cell, Li et al. (2016) show that KIF1Bβ binding releases calcineurin autoinhibition, leading to dephosphorylation of the DRP1 GTPase and subsequent mitochondrial fragmentation. KIF1Bβ impairment caus...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2016.01.005
更新日期:2016-01-25 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(04)00020-6
更新日期:2004-02-01 00:00:00
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journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2013.02.005
更新日期:2013-02-25 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.01.005
更新日期:2012-04-17 00:00:00
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journal_title:Developmental cell
pub_type: 评论,杂志文章,评审
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journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2016.04.022
更新日期:2016-05-09 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.02.010
更新日期:2016-03-07 00:00:00