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Linking Matrix Rigidity with EMT and Cancer Invasion.

Abstract：

:The extracellular matrix (ECM) plays a major role in cancer progression through its increased deposition and alignment. In this issue of Developmental Cell, Fattet et al. reveal a pathway in which ECM stiffness promotes EPHA2/LYN complex activation, leading to TWIST1 nuclear localization and triggering EMT in breast cancer.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Ros M,Sala M,Saltel F

doi

10.1016/j.devcel.2020.06.032

subject

Has Abstract

pub_date

2020-08-10 00:00:00

pages

293-295

issue

3

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(20)30540-2

journal_volume

54

pub_type

评论,杂志文章

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