Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response.

abstract：:Polarity is a prominent feature of both chemotaxis and cytokinesis. In chemotaxis, polarity is established by local accumulation of PI(3,4,5)P3 at the cell's leading edge, achieved through temporal and spatial regulation of PI3 kinases and the tumor suppressor, PTEN. We find that as migrating D. discoideum cells round...

journal_title：Developmental cell

authors： Janetopoulos C,Borleis J,Vazquez F,Iijima M,Devreotes P

更新日期：2005-04-01 00:00:00

abstract：:Histone protein synthesis is activated as cells enter S phase to allow packaging of the newly replicated DNA into chromatin. In this issue of Developmental Cell, Takayama and coworkers elucidate a mechanism for silencing histone expression at the end of S phase in S. pombe. Failure to shut off histone expression disru...

journal_title：Developmental cell

authors： Marzluff WF

更新日期：2010-03-16 00:00:00

abstract：:In the field of breast biology, there is a growing appreciation for the "gatekeeping function" of basal cells during development and disease processes yet mechanisms regulating the generation of these cells are poorly understood. Here, we report that the proliferation of basal cells is controlled by SLIT/ROBO1 signali...

journal_title：Developmental cell

authors： Macias H,Moran A,Samara Y,Moreno M,Compton JE,Harburg G,Strickland P,Hinck L

更新日期：2011-06-14 00:00:00

abstract：:High-molecular-weight hyaluronan, a major component of the extracellular matrix, is anti-oncogenic, whereas low-molecular-weight hyaluronan is pro-oncogenic, though the mechanisms underlying the size-dependent opposite bioactivities of hyaluronan remain uncertain. We show here that treatment with high-molecular-weight...

journal_title：Developmental cell

authors： Ooki T,Murata-Kamiya N,Takahashi-Kanemitsu A,Wu W,Hatakeyama M

更新日期：2019-05-20 00:00:00

abstract：:22q11 deletion (del22q11) syndrome is characterized genetically by heterozygous deletions within chromosome 22q11 and clinically by a constellation of congenital malformations of the aortic arch, heart, thymus, and parathyroid glands described as DiGeorge syndrome (DGS). Here, we report that compound heterozygosity of...

journal_title：Developmental cell

authors： Guris DL,Duester G,Papaioannou VE,Imamoto A

更新日期：2006-01-01 00:00:00

abstract：:Proteins are degraded from the ER by endoplasmic reticulum-associated degradation (ERAD). In a recent issue of Molecular Cell, Fleig et al. (2012) describe a role for a ubiquitin-binding rhomboid protease, RHBDL4, in degradation of select ERAD substrates. These findings and the significance of rhomboids and other intr...

journal_title：Developmental cell

authors： Tsai YC,Weissman AM

更新日期：2012-09-11 00:00:00

abstract：:The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA...

journal_title：Developmental cell

authors： Desrochers LM,Antonyak MA,Cerione RA

更新日期：2016-05-23 00:00:00

abstract：:PTEN is one of the most commonly lost tumor suppressors in human cancer and is known to inhibit insulin signaling. Eph receptor tyrosine kinases (RTKs) have also been implicated in cancer formation and progression, and they have diverse functions, including nervous and vascular system development. We show that in C. e...

journal_title：Developmental cell

authors： Brisbin S,Liu J,Boudreau J,Peng J,Evangelista M,Chin-Sang I

更新日期：2009-10-01 00:00:00

abstract：:Transmission of the human parasite Brugia malayi relies on the sustained production of larvae in blood. In this issue of Developmental Cell,Foray et al. (2018) use methods developed in the model nematode C. elegans to reveal how a symbiotic bacterium supports the female germ cell development underlying this massive fe...

journal_title：Developmental cell

authors： Haag ES,Lo TW

更新日期：2018-04-23 00:00:00

abstract：:Local translation allows spatial control of gene expression. Here, we performed a dual protein-mRNA localization screen, using smFISH on 523 human cell lines expressing GFP-tagged genes. 32 mRNAs displayed specific cytoplasmic localizations with local translation at unexpected locations, including cytoplasmic protrusi...

journal_title：Developmental cell

authors： Chouaib R,Safieddine A,Pichon X,Imbert A,Kwon OS,Samacoits A,Traboulsi AM,Robert MC,Tsanov N,Coleno E,Poser I,Zimmer C,Hyman A,Le Hir H,Zibara K,Peter M,Mueller F,Walter T,Bertrand E

更新日期：2020-09-28 00:00:00

abstract：:The identities of the ubiquitin-ligases active during myogenesis are largely unknown. Here we describe a RING-type E3 ligase complex specified by the adaptor protein, Ozz, a novel SOCS protein that is developmentally regulated and expressed exclusively in striated muscle. In mice, the absence of Ozz results in overt m...

journal_title：Developmental cell

authors： Nastasi T,Bongiovanni A,Campos Y,Mann L,Toy JN,Bostrom J,Rottier R,Hahn C,Conaway JW,Harris AJ,D'Azzo A

更新日期：2004-02-01 00:00:00

abstract：:The regulated release of polypeptides has a central role in physiology, behavior, and development, but the mechanisms responsible for production of the large dense core vesicles (LDCVs) capable of regulated release have remained poorly understood. Recent work has implicated cytosolic adaptor protein AP-3 in the recrui...

journal_title：Developmental cell

authors： Asensio CS,Sirkis DW,Maas JW Jr,Egami K,To TL,Brodsky FM,Shu X,Cheng Y,Edwards RH

更新日期：2013-11-25 00:00:00

abstract：:Wnt/β-catenin signaling plays critical roles during embryogenesis, tissue homeostasis, and regeneration. How Wnt-receptor complex activity is regulated is not yet fully understood. Here, we identify the Ly6 family protein LY6/PLAUR domain-containing 6 (Lypd6) as a positive feedback regulator of Wnt/β-catenin signaling...

journal_title：Developmental cell

authors： Özhan G,Sezgin E,Wehner D,Pfister AS,Kühl SJ,Kagermeier-Schenk B,Kühl M,Schwille P,Weidinger G

更新日期：2013-08-26 00:00:00

abstract：:COPII vesicles assemble at ER subdomains called transitional ER (tER) sites, but the mechanism that generates tER sites is unknown. To study tER biogenesis, we analyzed the transmembrane protein Sec12, which initiates COPII vesicle formation. Sec12 is concentrated at discrete tER sites in the budding yeast Pichia past...

journal_title：Developmental cell

authors： Soderholm J,Bhattacharyya D,Strongin D,Markovitz V,Connerly PL,Reinke CA,Glick BS

更新日期：2004-05-01 00:00:00

abstract：:Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to fibroblast-derived hemato-vascular precursors, in mouse placenta and emb...

journal_title：Developmental cell

authors： Calvanese V,Mikkola HK

更新日期：2016-03-07 00:00:00

abstract：:It is intuitive to speculate that nutrient availability may influence differentiation of mammalian cells. Nonetheless, a comprehensive complement of the molecular determinants involved in this process has not been elucidated yet. Here, we have investigated how nutrients (glucose) affect skeletal myogenesis. Glucose re...

journal_title：Developmental cell

authors： Fulco M,Cen Y,Zhao P,Hoffman EP,McBurney MW,Sauve AA,Sartorelli V

更新日期：2008-05-01 00:00:00

abstract：:The musculoskeletal system of vertebrates is derived from the embryonic mesoderm. Its structures are categorized as epaxial or hypaxial based on their adult position and innervation. The epaxial/hypaxial terminology is also used to describe regions of the embryonic somites based on fate mapping of somitic derivatives....

journal_title：Developmental cell

authors： Burke AC,Nowicki JL

更新日期：2003-02-01 00:00:00

abstract：:Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate ...

journal_title：Developmental cell

authors： Cayuso J,Dzementsei A,Fischer JC,Karemore G,Caviglia S,Bartholdson J,Wright GJ,Ober EA

更新日期：2016-11-07 00:00:00

abstract：:Recent studies have yielded a number of important insights into the mechanisms of hair follicle development and cycling and have highlighted the particularly important roles played by stem cells and Wnt signaling pathways. ...

journal_title：Developmental cell

authors： Fuchs E,Merrill BJ,Jamora C,DasGupta R

更新日期：2001-07-01 00:00:00

abstract：:Mutations in Pkd1, encoding polycystin-1 (PC1), cause autosomal-dominant polycystic kidney disease (ADPKD). We show that the carboxy-terminal tail (CTT) of PC1 is released by γ-secretase-mediated cleavage and regulates the Wnt and CHOP pathways by binding the transcription factors TCF and CHOP, disrupting their intera...

journal_title：Developmental cell

authors： Merrick D,Chapin H,Baggs JE,Yu Z,Somlo S,Sun Z,Hogenesch JB,Caplan MJ

更新日期：2012-01-17 00:00:00

abstract：:Formation of the embryonic heart tube requires the medial migration and merger of bilateral precursor populations. A new study of zebrafish cardiogenesis published in this issue of Developmental Cell indicates that precursor migration involves formation of a coherent epithelium and that fibronectin plays an important ...

journal_title：Developmental cell

authors： Glickman NS,Yelon D

更新日期：2004-03-01 00:00:00

abstract：:The Frizzled (Fz) receptor is required cell autonomously in Wnt/beta-catenin and planar cell polarity (PCP) signaling. In addition to these requirements, Fz acts nonautonomously during PCP establishment: wild-type cells surrounding fz(-) patches reorient toward the fz(-) cells. The molecular mechanism(s) of nonautonom...

journal_title：Developmental cell

authors： Wu J,Mlodzik M

更新日期：2008-09-01 00:00:00

abstract：:Infectious, self-propagating protein aggregates (prions) as well as structurally related amyloid fibrils have traditionally been associated with neurodegenerative diseases in mammals. However, recent work in fungi indicates that prions are not simply aberrations of protein folding, but are in fact widespread, conserve...

journal_title：Developmental cell

authors： Osherovich LZ,Weissman JS

更新日期：2002-02-01 00:00:00

abstract：:Reporting in Cell, Berg et al. (2016) reveal a connection between genetic lysosomal storage disorders and the ability of macrophages to migrate and control mycobacterial infection. This insight, resulting from a zebrafish genetic screen, inspired the authors to propose an explanation for the increased susceptibility o...

journal_title：Developmental cell

authors： Meijer AH,Aerts JM

更新日期：2016-04-18 00:00:00

abstract：:Selection of the correct targets for myelination and regulation of myelin sheath growth are essential for central nervous system (CNS) formation and function. Through a genetic screen in zebrafish and complementary analyses in mice, we find that loss of oligodendrocyte Neurofascin leads to mistargeting of myelin to ce...

journal_title：Developmental cell

authors： Klingseisen A,Ristoiu AM,Kegel L,Sherman DL,Rubio-Brotons M,Almeida RG,Koudelka S,Benito-Kwiecinski SK,Poole RJ,Brophy PJ,Lyons DA

更新日期：2019-12-16 00:00:00

abstract：:Changes to cell shape and interaction drive animal tissue morphogenesis. Reporting now in Developmental Cell, Del Signore et al. (2018) describe active lengthening of cell-cell contacts by Arp2/3-based actin networks. Through cycles of contact lengthening and shortening, the developing Drosophila eye passes through va...

journal_title：Developmental cell

authors： Zhang Y,Harris TJC

更新日期：2018-02-26 00:00:00

abstract：:The Hox family transcription factors control diversified morphogenesis during development and evolution. They function in concert with Pbc cofactor proteins. Pbc proteins bind the Hox hexapeptide (HX) motif and are thereby thought to confer DNA binding specificity. Here we report that mutation of the AbdA HX motif doe...

journal_title：Developmental cell

authors： Merabet S,Kambris Z,Capovilla M,Bérenger H,Pradel J,Graba Y

更新日期：2003-05-01 00:00:00

abstract：:During embryonic development, cells must establish fates, morphologies, and behaviors in coordination with one another to form a functional body. A prevalent hypothesis for how this coordination is achieved is that each cell's fate and behavior is determined by a defined mixture of RNAs. Only recently has it become po...

journal_title：Developmental cell

authors： Tintori SC,Osborne Nishimura E,Golden P,Lieb JD,Goldstein B

更新日期：2016-08-22 00:00:00

abstract：:Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively stud...

journal_title：Developmental cell

authors： Curran S,Strandkvist C,Bathmann J,de Gennes M,Kabla A,Salbreux G,Baum B

更新日期：2017-11-20 00:00:00

abstract：:The anterior visceral endoderm plays a pivotal role in establishing anterior-posterior polarity of the mouse embryo, but the molecular nature of the signals required remains to be determined. Here, we demonstrate that Cerberus-like(-/-);Lefty1(-/-) compound mutants can develop a primitive streak ectopically in the emb...

journal_title：Developmental cell

authors： Perea-Gomez A,Vella FD,Shawlot W,Oulad-Abdelghani M,Chazaud C,Meno C,Pfister V,Chen L,Robertson E,Hamada H,Behringer RR,Ang SL

更新日期：2002-11-01 00:00:00