Abstract：
:Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essential for larval development. We found that lysosomes are specifically activated in the epidermis at molt when the apical ECM (cuticle) is being replaced. Impaired lysosome function affects endocytic cargo degradation, suppresses elevated protein synthesis at molt, and causes molting defects. Disturbance of ECM-epidermis attachments triggers lysosomal activation and induces expression of the vacuolar H+-ATPase (V-ATPase), which is mediated by the GATA transcription factor ELT-3 and the STAT family protein STA-2. Our study reveals an ECM-to-nucleus signaling pathway that activates lysosomes to facilitate ECM remodeling essential for larval development.
journal_name
Dev Celljournal_title
Developmental cellauthors
Miao R,Li M,Zhang Q,Yang C,Wang Xdoi
10.1016/j.devcel.2019.10.020subject
Has Abstractpub_date
2020-01-06 00:00:00pages
21-37.e5issue
1eissn
1534-5807issn
1878-1551pii
S1534-5807(19)30867-6journal_volume
52pub_type
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