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The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation.

Abstract：

:Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during mitosis-a process termed centrosome maturation. How centrosomes mature remains mysterious. Here, we identify a domain in Drosophila Cnn that appears to be phosphorylated by Polo/Plk1 specifically at centrosomes during mitosis. The phosphorylation promotes the assembly of a Cnn scaffold around the centrioles that is in constant flux, with Cnn molecules recruited continuously around the centrioles as the scaffold spreads slowly outward. Mutations that block Cnn phosphorylation strongly inhibit scaffold assembly and centrosome maturation, whereas phosphomimicking mutations allow Cnn to multimerize in vitro and to spontaneously form cytoplasmic scaffolds in vivo that organize microtubules independently of centrosomes. We conclude that Polo/Plk1 initiates the phosphorylation-dependent assembly of a Cnn scaffold around centrioles that is essential for efficient centrosome maturation in flies.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Conduit PT,Feng Z,Richens JH,Baumbach J,Wainman A,Bakshi SD,Dobbelaere J,Johnson S,Lea SM,Raff JW

doi

10.1016/j.devcel.2014.02.013

subject

Has Abstract

pub_date

2014-03-31 00:00:00

pages

659-69

issue

6

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(14)00129-4

journal_volume

28

pub_type

杂志文章

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