Abstract：
:Multinucleate cells are widespread in nature, yet the mechanism by which cells fuse their plasma membranes is poorly understood. To identify animal fusogens, we performed new screens for mutations that abolish cell fusion within tissues of C. elegans throughout development. We identified the gene eff-1, which is expressed as cells acquire fusion competence and encodes a novel integral membrane protein. EFF-1 sequence motifs suggest physicochemical actions that could cause adjacent bilayers to fuse. Mutations in the extracellular domain of EFF-1 completely block epithelial cell membrane fusion without affecting other perfusion events such as cell generation, patterning, differentiation, and adhesion. Thus, EFF-1 is a key component in the mechanism of cell fusion, a process essential to normal animal development.
journal_name
Dev Celljournal_title
Developmental cellauthors
Mohler WA,Shemer G,del Campo JJ,Valansi C,Opoku-Serebuoh E,Scranton V,Assaf N,White JG,Podbilewicz Bdoi
10.1016/s1534-5807(02)00129-6keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
355-62issue
3eissn
1534-5807issn
1878-1551pii
S1534-5807(02)00129-6journal_volume
2pub_type
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