Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis.

abstract：:The vertebral column derives from somites generated by segmentation of presomitic mesoderm (PSM). Somitogenesis involves a molecular oscillator, the segmentation clock, controlling periodic Notch signaling in the PSM. Here, we establish a novel link between Wnt/beta-catenin signaling and the segmentation clock. Axin2,...

journal_title：Developmental cell

authors： Aulehla A,Wehrle C,Brand-Saberi B,Kemler R,Gossler A,Kanzler B,Herrmann BG

更新日期：2003-03-01 00:00:00

abstract：:Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...

journal_title：Developmental cell

authors： Gonzales KAU,Fuchs E

更新日期：2017-11-20 00:00:00

abstract：:How metabolism is rewired during embryonic development is still largely unknown, as it remains a major technical challenge to resolve metabolic activities or metabolite levels with spatiotemporal resolution. Here, we investigated metabolic changes during development of organogenesis-stage mouse embryos, focusing on th...

journal_title：Developmental cell

authors： Bulusu V,Prior N,Snaebjornsson MT,Kuehne A,Sonnen KF,Kress J,Stein F,Schultz C,Sauer U,Aulehla A

更新日期：2017-02-27 00:00:00

abstract：:Passenger proteins migrate from inner centromeres to the spindle midzone during late mitosis, and those described to date are essential both for proper chromosome segregation and for completion of cell cleavage. We have purified and cloned the human passenger protein TD-60, and we here report that it is a member of th...

journal_title：Developmental cell

authors： Mollinari C,Reynaud C,Martineau-Thuillier S,Monier S,Kieffer S,Garin J,Andreassen PR,Boulet A,Goud B,Kleman JP,Margolis RL

更新日期：2003-08-01 00:00:00

abstract：:CLIPs are microtubule plus end-associated proteins that mediate interactions required for cell polarity and cell division. Here we demonstrate that budding yeast Bik1, unlike its human ortholog CLIP-170, is targeted to the microtubule plus end by a kinesin-dependent transport mechanism. Bik1 forms a complex with the k...

journal_title：Developmental cell

authors： Carvalho P,Gupta ML Jr,Hoyt MA,Pellman D

更新日期：2004-06-01 00:00:00

abstract：:Regulated turnover of integrin receptors is essential for cell adhesion and migration. Pathways selectively regulating β1-integrin recycling are implicated in cancer invasion and metastasis, yet proteins required for the internalization of this pro-invasive integrin remain to be identified. Here, we uncover formin-lik...

journal_title：Developmental cell

authors： Wang Y,Arjonen A,Pouwels J,Ta H,Pausch P,Bange G,Engel U,Pan X,Fackler OT,Ivaska J,Grosse R

更新日期：2015-08-24 00:00:00

abstract：:Cell polarity plays a key role in the development of the central nervous system (CNS). Interestingly, disruption of cell polarity is seen in many cancers. ASPP2 is a haplo-insufficient tumor suppressor and an activator of the p53 family. In this study, we show that ASPP2 controls the polarity and proliferation of neur...

journal_title：Developmental cell

authors： Sottocornola R,Royer C,Vives V,Tordella L,Zhong S,Wang Y,Ratnayaka I,Shipman M,Cheung A,Gaston-Massuet C,Ferretti P,Molnár Z,Lu X

更新日期：2010-07-20 00:00:00

abstract：:Plasma membrane subdomains enriched in sphingolipids, cholesterol, and signaling proteins are critical for organization of actin, membrane trafficking, and cell polarity, but the role of such domains in cytokinesis in animal cells is unknown. Here, we show that eggs form a plasma membrane domain enriched in gangliosid...

journal_title：Developmental cell

authors： Ng MM,Chang F,Burgess DR

更新日期：2005-12-01 00:00:00

abstract：:Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during mitosis-a process termed centrosome maturation. How centrosomes mature remains mysterious. Here, we identify a domain in Drosophila Cnn that appears to be phospho...

journal_title：Developmental cell

authors： Conduit PT,Feng Z,Richens JH,Baumbach J,Wainman A,Bakshi SD,Dobbelaere J,Johnson S,Lea SM,Raff JW

更新日期：2014-03-31 00:00:00

abstract：:The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the consequences of depleting breast cancer cells of SIRT1. We discovered tha...

journal_title：Developmental cell

authors： Latifkar A,Ling L,Hingorani A,Johansen E,Clement A,Zhang X,Hartman J,Fischbach C,Lin H,Cerione RA,Antonyak MA

更新日期：2019-05-06 00:00:00

abstract：:The AMP-stimulated protein kinase regulates epithelial polarity under conditions of energy depletion by phosphorylating the myosin regulatory light chain. In this issue of Developmental Cell, Mirouse et al. demonstrate that dystroglycan and perlecan, an extracellular matrix receptor and its ligand, help localize myosi...

journal_title：Developmental cell

authors： Zhang L,Seo-Mayer P,Caplan MJ

更新日期：2009-01-01 00:00:00

abstract：:Many patterns of cell and tissue organization are specified during development by gradients of morphogens, substances that assign different cell fates at different concentrations. Gradients form by morphogen transport from a localized site, but whether this occurs by simple diffusion or by more elaborate mechanisms is...

journal_title：Developmental cell

authors： Lander AD,Nie Q,Wan FY

更新日期：2002-06-01 00:00:00

abstract：:The Hox family transcription factors control diversified morphogenesis during development and evolution. They function in concert with Pbc cofactor proteins. Pbc proteins bind the Hox hexapeptide (HX) motif and are thereby thought to confer DNA binding specificity. Here we report that mutation of the AbdA HX motif doe...

journal_title：Developmental cell

authors： Merabet S,Kambris Z,Capovilla M,Bérenger H,Pradel J,Graba Y

更新日期：2003-05-01 00:00:00

abstract：:TORC1 regulates growth and metabolism, in part, by influencing transcriptional programs. Here, we identify REPTOR and REPTOR-BP as transcription factors downstream of TORC1 that are required for ∼ 90% of the transcriptional induction that occurs upon TORC1 inhibition in Drosophila. Thus, REPTOR and REPTOR-BP are major...

journal_title：Developmental cell

authors： Tiebe M,Lutz M,De La Garza A,Buechling T,Boutros M,Teleman AA

更新日期：2015-05-04 00:00:00

abstract：:Intercellular communication is vital to tumor progression. In this issue of Developmental Cell, Bertolini et al. (2020) describe how small extracellular vesicles released from hypoxic mammary tumor cells facilitate intercellular communication, leading to alterations in mitochondrial dynamics and acquisition of invasiv...

journal_title：Developmental cell

authors： Boomgarden AC,Clancy JW,D'Souza-Schorey C

更新日期：2020-10-26 00:00:00

abstract：:Orientation of cell division is a vital aspect of tissue morphogenesis and growth. Asymmetric divisions generate cell fate diversity and epithelial stratification, whereas symmetric divisions contribute to tissue growth, spreading, and elongation. Here, we describe a mechanism for positioning the spindle in symmetric ...

journal_title：Developmental cell

authors： Woolner S,Papalopulu N

更新日期：2012-04-17 00:00:00

abstract：:The lymphatic system is crucial for fluid homeostasis, immune responses, and numerous pathological processes. However, the molecular mechanisms responsible for establishing the anatomical form of the lymphatic vascular network remain largely unknown. Here, we show that chemokine signaling provides critical guidance cu...

journal_title：Developmental cell

authors： Cha YR,Fujita M,Butler M,Isogai S,Kochhan E,Siekmann AF,Weinstein BM

更新日期：2012-04-17 00:00:00

abstract：:Epithelial tubes are found in many vital organs and require uniform and correct tube diameters for optimal function. Tube size depends on apical membrane growth and subapical cytoskeletal reorganization, but the cues that coordinate these events to ensure functional tube shape remain elusive. We find that epithelial t...

journal_title：Developmental cell

authors： Tonning A,Hemphälä J,Tång E,Nannmark U,Samakovlis C,Uv A

更新日期：2005-09-01 00:00:00

abstract：:In this issue of Developmental Cell, Ren et al. (2019) identify the embryonic origin of cardiac pacemaker cells in zebrafish and implicate Wnt5b in promoting their differentiation. Furthermore, canonical Wnt activation in human stem cell-derived cardiac progenitors produces functional pacemaker cells in vitro, advanci...

journal_title：Developmental cell

authors： Burns CG,Burns CE

更新日期：2019-09-23 00:00:00

abstract：:Neuroblastomas are associated with KIF1Bβ mutations within tumor suppressor region 1p36. In this issue of Developmental Cell, Li et al. (2016) show that KIF1Bβ binding releases calcineurin autoinhibition, leading to dephosphorylation of the DRP1 GTPase and subsequent mitochondrial fragmentation. KIF1Bβ impairment caus...

journal_title：Developmental cell

authors： Blackstone C

更新日期：2016-01-25 00:00:00

abstract：:We studied the role of the target of rapamycin complex 2 (mTORC2) during neutrophil chemotaxis, a process that is mediated through the polarization of actin and myosin filament networks. We show that inhibition of mTORC2 activity, achieved via knock down (KD) of Rictor, severely inhibits neutrophil polarization and di...

journal_title：Developmental cell

authors： Liu L,Das S,Losert W,Parent CA

更新日期：2010-12-14 00:00:00

abstract：:Wingless (Wg) is a morphogen required for the patterning of many Drosophila tissues. Several lines of evidence implicate heparan sulfate-modified proteoglycans (HSPGs) such as Dally-like protein (Dlp) in the control of Wg distribution and signaling. We show that dlp is required to limit Wg levels in the matrix, contra...

journal_title：Developmental cell

authors： Kirkpatrick CA,Dimitroff BD,Rawson JM,Selleck SB

更新日期：2004-10-01 00:00:00

abstract：:Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to fibroblast-derived hemato-vascular precursors, in mouse placenta and emb...

journal_title：Developmental cell

authors： Calvanese V,Mikkola HK

更新日期：2016-03-07 00:00:00

abstract：:The glucose transporter type 4 (glut4) is critical for metabolic homeostasis. Insulin regulates glut4 by modulating its expression on the cell surface. This regulation is mainly achieved by targeting the endocytic recycling of glut4. We identify general receptor for 3-phosphoinositides 1 (Grp1) as a guanine nucleotide...

journal_title：Developmental cell

authors： Li J,Malaby AW,Famulok M,Sabe H,Lambright DG,Hsu VW

更新日期：2012-06-12 00:00:00

abstract：:Centromeres are essential for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes. Mis-targeted CENP-A chromatin has been shown to seed centromeres at non-centromeric DNA. However, the requirements for such de novo centromere formation and transmission in vivo remain unknown. He...

journal_title：Developmental cell

authors： Palladino J,Chavan A,Sposato A,Mason TD,Mellone BG

更新日期：2020-02-10 00:00:00

abstract：:As they enter mitosis, animal cells undergo profound actin-dependent changes in shape to become round. Here we identify the Cdk1 substrate, Ect2, as a central regulator of mitotic rounding, thus uncovering a link between the cell-cycle machinery that drives mitotic entry and its accompanying actin remodeling. Ect2 is ...

journal_title：Developmental cell

authors： Matthews HK,Delabre U,Rohn JL,Guck J,Kunda P,Baum B

更新日期：2012-08-14 00:00:00

abstract：:Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players. ...

journal_title：Developmental cell

authors： Donaldson JG

更新日期：2003-10-01 00:00:00

abstract：:During development, primordial germ cells (PGCs) navigate a complex journey to generate the germline. In a recent paper in Nature Cell Biology, Nance and colleagues (Abdu et al., 2016) have discovered an unexpected step along the way: PGCs get cut in half by endodermal cells. ...

journal_title：Developmental cell

authors： Krishna S,Overholtzer M

更新日期：2016-12-19 00:00:00

abstract：:Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The initial positioning of folds is the foundation for the emergence of correct tissue morphology. Mechanisms forming individual folds have been studied, but the precise positioning of folds in complex, multi-folded epithelia is less...

journal_title：Developmental cell

authors： Tozluoǧlu M,Duda M,Kirkland NJ,Barrientos R,Burden JJ,Muñoz JJ,Mao Y

更新日期：2019-11-04 00:00:00

abstract：:Vertebrate hematopoiesis first produces primitive (embryonic) lineages and ultimately generates the definitive (adult) blood. Whereas definitive hematopoiesis may produce many diverse blood types via a common multipotent progenitor, primitive hematopoiesis has been thought to produce only erythrocytes or macrophages v...

journal_title：Developmental cell

authors： Warga RM,Kane DA,Ho RK

更新日期：2009-05-01 00:00:00