Abstract:
:The glucose transporter type 4 (glut4) is critical for metabolic homeostasis. Insulin regulates glut4 by modulating its expression on the cell surface. This regulation is mainly achieved by targeting the endocytic recycling of glut4. We identify general receptor for 3-phosphoinositides 1 (Grp1) as a guanine nucleotide exchange factor for ADP-ribosylation factor 6 (ARF6) that promotes glut4 vesicle formation. Grp1 also promotes the later steps of glut4 recycling through ARF6. Insulin signaling regulates Grp1 through phosphorylation by Akt. We also find that mutations that mimic constitutive phosphorylation of Grp1 can bypass upstream insulin signaling to induce glut4 recycling. Thus, we have uncovered a major mechanism by which insulin regulates glut4 recycling. Our findings also reveal the complexity by which a single small GTPase in vesicular transport can coordinate its multiple steps to accomplish a round of transport.
journal_name
Dev Celljournal_title
Developmental cellauthors
Li J,Malaby AW,Famulok M,Sabe H,Lambright DG,Hsu VWdoi
10.1016/j.devcel.2012.03.004subject
Has Abstractpub_date
2012-06-12 00:00:00pages
1286-98issue
6eissn
1534-5807issn
1878-1551pii
S1534-5807(12)00127-Xjournal_volume
22pub_type
杂志文章abstract::Pancreatic beta cell proliferation is high at birth and then rapidly declines. In this issue of Developmental Cell,Stolovich-Rain et al. (2015) show that β cells' capacity to increase proliferation in response to injury is unexpectedly not acquired until after weaning-related nutritional changes trigger a metabolic an...
journal_title:Developmental cell
pub_type: 评论,杂志文章
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abstract::Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively stud...
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abstract::Mutations in Pkd1, encoding polycystin-1 (PC1), cause autosomal-dominant polycystic kidney disease (ADPKD). We show that the carboxy-terminal tail (CTT) of PC1 is released by γ-secretase-mediated cleavage and regulates the Wnt and CHOP pathways by binding the transcription factors TCF and CHOP, disrupting their intera...
journal_title:Developmental cell
pub_type: 杂志文章
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abstract::Cell constriction promotes epithelial sheet invagination during embryogenesis across phyla. However, how this cell response is linked to global patterning information during organogenesis remains unclear. To address this issue, we have used the Drosophila eye and studied the formation of the morphogenetic furrow (MF),...
journal_title:Developmental cell
pub_type: 杂志文章
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abstract::Pericytes are critical for cerebrovascular maturation and development of the blood-brain barrier (BBB), but their role in maintenance of the adult BBB, and how CNS pericytes differ from those of other tissues, is less well understood. We show that the forkhead transcription factor Foxf2 is specifically expressed in pe...
journal_title:Developmental cell
pub_type: 杂志文章
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abstract::CPEB is a sequence-specific RNA binding protein that regulates translation during vertebrate oocyte maturation. Adult female CPEB knockout mice contained vestigial ovaries that were devoid of oocytes; ovaries from mid-gestation embryos contained oocytes that were arrested at the pachytene stage. Male CPEB null mice al...
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journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.03.019
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journal_title:Developmental cell
pub_type: 评论,杂志文章
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journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 杂志文章,评审
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更新日期:2017-05-22 00:00:00
abstract::The 6th European Meiosis Workshop, sponsored by EMBO and organized by Franz Klein of the University of Vienna, met in mid-September. More than 150 participants who have not discovered anything more interesting than sex gathered in a bucolic Alpine valley near the town of Obertraun, Austria, surrounded by granite massi...
journal_title:Developmental cell
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journal_title:Developmental cell
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doi:10.1016/j.devcel.2010.07.011
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journal_title:Developmental cell
pub_type: 评论,杂志文章,评审
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abstract::Mammalian neurulation is completed when the dorsolateral neural folds bend inwards, their tips make adhesive contacts across the midline, and the epithelia remodel to create a closed neural tube. Two recent papers (one by Camerer et al. in this issue of Developmental Cell) demonstrate a vital role for protease-activat...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2010.01.002
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pub_type: 杂志文章
doi:10.1016/j.devcel.2015.12.014
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pub_type: 杂志文章,评审
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abstract::Nuclear size plays pivotal roles in gene expression, embryo development, and disease. A central hypothesis in organisms ranging from yeast to vertebrates is that nuclear size scales to cell size. This implies that nuclei may reach steady-state sizes set by limiting cytoplasmic pools of size-regulating components. By m...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.05.003
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journal_title:Developmental cell
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journal_title:Developmental cell
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doi:10.1016/j.devcel.2013.09.002
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journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 评论,杂志文章
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journal_title:Developmental cell
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journal_title:Developmental cell
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