Abstract:
:In this issue of Developmental Cell, Schuster et al. (2014) describe the signals regulated by the bHLH transcription factor HEC1 during Arabidopsis stem cell maintenance. HEC1 acts antagonistically with other factors, integrating multiple cues to provide a balance between cellular differentiation and proliferation.
journal_name
Dev Celljournal_title
Developmental cellauthors
Sparks EE,Benfey PNdoi
10.1016/j.devcel.2014.02.006subject
Has Abstractpub_date
2014-02-24 00:00:00pages
349-50issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(14)00099-9journal_volume
28pub_type
评论,杂志文章abstract::One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an ant...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.11.027
更新日期:2020-12-21 00:00:00
abstract::Vertebrate hematopoiesis first produces primitive (embryonic) lineages and ultimately generates the definitive (adult) blood. Whereas definitive hematopoiesis may produce many diverse blood types via a common multipotent progenitor, primitive hematopoiesis has been thought to produce only erythrocytes or macrophages v...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.04.007
更新日期:2009-05-01 00:00:00
abstract::Heparan sulfate (HS) proteoglycans modulate the activity of multiple growth factors on the cell surface and extracellular matrix. However, it remains unclear how the HS chains control the movement and reception of growth factors into targeted receiving cells during mammalian morphogenetic processes. Here, we found tha...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.06.027
更新日期:2011-08-16 00:00:00
abstract::Regulating the osmotic pressure of our body fluids relies on osmosensory neurons that depolarize when their volume decreases. Recently in Neuron, Prager-Khoutorsky et al. (2014) report that this depolarization arises from direct interactions between the transient receptor potential channel TRPV1 and microtubules, whic...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2014.08.012
更新日期:2014-08-25 00:00:00
abstract::Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2017.02.020
更新日期:2017-03-27 00:00:00
abstract::Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki et al. (2013) suggest that the ER-...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2013.04.004
更新日期:2013-04-29 00:00:00
abstract::The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of these isolated neurons. Their profiles were similarly...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.10.024
更新日期:2013-12-09 00:00:00
abstract::The large GTPase Dynamin 2 (Dyn2) is markedly upregulated in pancreatic cancer, is a potent activator of metastatic migration, and is required for Rac1-mediated formation of lamellipodia. Here we demonstrate an unexpected mechanism of Dyn2 action in these contexts via direct binding to the Rac1 guanine nucleotide exch...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.02.010
更新日期:2013-03-25 00:00:00
abstract::Myelin is essential in vertebrates for the rapid propagation of action potentials, but the molecular mechanisms driving its formation remain largely unknown. Here we show that the initial stage of process extension and axon ensheathment by oligodendrocytes requires dynamic actin filament assembly by the Arp2/3 complex...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.06.011
更新日期:2015-07-27 00:00:00
abstract::The faithful alignment of homologous chromosomes during meiotic prophase requires the coordination of DNA double-strand break (DSB) repair with large-scale chromosome reorganization. Here we identify the phosphatase PP4 (Pph3/Psy2) as a mediator of this process in Saccharomyces cerevisiae. In pp4 mutants, early stages...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.09.006
更新日期:2010-10-19 00:00:00
abstract::The adaptor complex AP-2 plays an important role in cargo selection and clathrin lattice formation during clathrin-mediated endocytosis. In a recent issue of Molecular Cell, Honing et al. demonstrate that high-affinity AP-2 membrane association is achieved through a combination of low-affinity interactions with membra...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.05.013
更新日期:2005-06-01 00:00:00
abstract::Blood vessels form an important interface between the environment and the organism by carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is therefore not surprising that oxygen and metabolism influence the development of the vascular network. Here, we discuss recent insights regard...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2009.01.003
更新日期:2009-02-01 00:00:00
abstract::Bacteria display an array of contact-dependent interaction systems that have evolved to facilitate direct cell-to-cell communication. We have previously identified a mode of bacterial communication mediated by nanotubes bridging neighboring cells. Here, we elucidate nanotube architecture, dynamics, and molecular compo...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.01.013
更新日期:2016-02-22 00:00:00
abstract::The insulin-like peptide (ILP) family plays key biological roles in the control of body growth. Although the functions of ILPs are well understood, the mechanisms by which organisms sense their nutrient status and thereby control ILP production remain largely unknown. Here, we show that signaling relay and feedback me...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.10.003
更新日期:2015-11-09 00:00:00
abstract::During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell-cycle progression, and cytokinesis. Rac1 null cells migrate markedly less efficiently, but s...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.07.008
更新日期:2011-10-18 00:00:00
abstract::Exposing cells to folding stress causes a subset of their proteins to misfold and accumulate in inclusion bodies (IBs). IB formation and clearance are both active processes, but little is known about their mechanism. To shed light on this issue, we performed a screen with over 4,000 fluorescently tagged yeast proteins...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.04.015
更新日期:2015-06-08 00:00:00
abstract::Initiation of DNA replication must be restricted to occur only once per cell cycle. In most bacteria, DnaA protein binds replication origins and promotes the initiation of DNA replication. We have found that in Bacillus subtilis, DnaA only colocalizes with origin regions at early or late stages of the cell cycle, when...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.09.010
更新日期:2008-12-01 00:00:00
abstract::The eukaryotic nucleus has been the neglected child of cell biology. The "International Symposium on Functional Organization of the Nucleus" held in January on Awaji Island, Japan, highlighted recent work on nuclear organization and function. Emerging from this conference was a holistic view in which diverse chemical ...
journal_title:Developmental cell
pub_type:
doi:10.1016/j.devcel.2007.02.014
更新日期:2007-03-01 00:00:00
abstract::Enhancers are the primary determinants of cell identity, but the regulatory components controlling enhancer turnover during lineage commitment remain largely unknown. Here we compare the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progeni...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.12.014
更新日期:2016-01-11 00:00:00
abstract::The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2016.04.019
更新日期:2016-05-23 00:00:00
abstract::The vertebral column derives from somites generated by segmentation of presomitic mesoderm (PSM). Somitogenesis involves a molecular oscillator, the segmentation clock, controlling periodic Notch signaling in the PSM. Here, we establish a novel link between Wnt/beta-catenin signaling and the segmentation clock. Axin2,...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00055-8
更新日期:2003-03-01 00:00:00
abstract::The sense organs of the vertebrate head comprise structures as varied as the eye, inner ear, and olfactory epithelium. In the early embryo, these assorted structures share a common developmental origin within the preplacodal region and acquire specific characteristics only later. Here we demonstrate a fundamental simi...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.08.009
更新日期:2006-10-01 00:00:00
abstract::Differentiated cells have evolved mechanisms to adapt the functions of the late secretory pathway to the specific needs of the organism. Reporting in this issue of Developmental Cell, Polishchuk et al. (2014) demonstrate that hepatocytes utilize a unique exocytic aspect of the late endosomal/lysosomal compartment to m...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2014.06.002
更新日期:2014-06-23 00:00:00
abstract::Early leaf growth is sustained by cell proliferation and subsequent cell expansion that initiates at the leaf tip and proceeds in a basipetal direction. Using detailed kinematic and gene expression studies to map these stages during early development of the third leaf of Arabidopsis thaliana, we showed that the cell-c...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.11.011
更新日期:2012-01-17 00:00:00
abstract::The myogenic regulatory genes Myf5, Mrf4, Myod, and Myogenin likely arose by gene duplications during evolution, presumably to address the more demanding requirements of the vertebrate body plan. Two cell lineages were proposed to be regulated independently by Myf5 and Myod to safeguard against tissue failure. Here we...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.11.005
更新日期:2014-12-08 00:00:00
abstract::Despite their external bilateral symmetry, vertebrates have internal left/right (L/R) asymmetries required for optimal organ function. BMP-induced epithelial to mesenchymal transition (EMT) in the lateral plate mesoderm (LPM) triggers L/R asymmetric cell movements toward the midline, higher from the right, which are c...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.09.012
更新日期:2019-11-18 00:00:00
abstract::The Drosophila lipoprotein particle, Lipophorin, bears lipid-linked morphogens on its surface and is required for long-range signaling activity of Wingless and Hedgehog. Heparan sulfate proteoglycans are also critical for trafficking and signaling of these morphogens. Here we show that Lipophorin interacts with the he...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.04.019
更新日期:2007-07-01 00:00:00
abstract::To maintain proper organ size, nature has devised trans-organ communication systems-involving both paracrine and circulating regulatory factors-to safeguard homeostasis. In this issue of Developmental Cell, Ji et al. (2019) now describe an enterohepatic feedback loop that balances tissue size and function in the mamma...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2019.02.008
更新日期:2019-02-25 00:00:00
abstract::Embryonic development of the liver has been studied intensely, yielding insights that impact diverse areas of developmental and cell biology. Understanding the fundamental mechanisms that control hepatogenesis has also laid the basis for the rational differentiation of stem cells into cells that display many hepatic f...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2010.01.011
更新日期:2010-02-16 00:00:00
abstract::When two colonies of the tunicate Botryllus contact each other, they either fuse into a single colony or mount a destructive reaction, which keeps them apart. Which of the two reactions takes place is determined by a single, highly polymorphic fusion/histocompatibility (FuHC) locus. Recent communications report the cl...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.12.009
更新日期:2006-01-01 00:00:00