Abstract：
:The musculoskeletal system of vertebrates is derived from the embryonic mesoderm. Its structures are categorized as epaxial or hypaxial based on their adult position and innervation. The epaxial/hypaxial terminology is also used to describe regions of the embryonic somites based on fate mapping of somitic derivatives. However, the adult, functional distinctions are not fully consistent with the changing embryonic environments of mesodermal populations during morphogenesis, and the traditional terminology loses accuracy when used to describe certain mutant phenotypes. Here we describe a new terminology naming two mesodermal environments defined by the lineage of the included cells. We discuss how mutant phenotypes may be better explained by consideration of the embryonic context in which genes take their effect and argue that the recognition of these embryonic territories clarifies description and discussion of the morphogenesis and patterning of the musculoskeletal system.
journal_name
Dev Celljournal_title
Developmental cellauthors
Burke AC,Nowicki JLdoi
10.1016/s1534-5807(03)00033-9keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
159-65issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(03)00033-9journal_volume
4pub_type
杂志文章,评审abstract：:Spindle positioning is an essential feature of asymmetric cell division. The conserved PAR proteins together with heterotrimeric G proteins control spindle positioning in animal cells, but how these are linked is not known. In C. elegans, PAR protein activity leads to asymmetric spindle placement through cortical asym...
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abstract：:The gut absorbs dietary nutrients and provides a barrier to xenobiotics and microbiome metabolites. To cope with toxin exposures, the intestinal epithelium is one of the most rapidly proliferating tissues in the body. The stem cell niche supplies essential signaling factors including Wnt proteins secreted by subepithe...
journal_title：Developmental cell
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journal_title：Developmental cell
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abstract：:The viral genomes of alpha- and gamma-retroviruses follow an outbound route through the cytoplasm before assembling with the budding particle at the plasma membrane. We show here that murine leukemia virus (MLV) RNAs are transported on lysosomes and transferrin-positive endosomes. Transport on transferrin-positive ves...
journal_title：Developmental cell
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abstract：:Reporting in Nature, Sanders et al. (2013) implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb. Actin-based filopodia transport Shh from producing cells, while filopodia of responding cells bear Cdon and Boc: coreceptors in the Shh pathway. These findings suggest a new mechanism of ligand m...
journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
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journal_title：Developmental cell
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更新日期：2021-01-11 00:00:00
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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更新日期：2012-05-15 00:00:00
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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更新日期：2008-06-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.07.009
更新日期：2018-08-06 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.01.028
更新日期：2020-04-06 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.01.023
更新日期：2013-03-11 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.02.010
更新日期：2007-03-01 00:00:00
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journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2016.02.022
更新日期：2016-03-07 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2010-07-20 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2008-10-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章,评审
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pub_type： 评论,杂志文章
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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更新日期：2012-09-11 00:00:00
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journal_title：Developmental cell
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journal_title：Developmental cell
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更新日期：2017-12-04 00:00:00
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章
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