Abstract：
:All pancreatic endocrine cells, producing glucagon, insulin, somatostatin, or PP, differentiate from Pdx1+ progenitors that transiently express Neurogenin3. To understand whether the competence of pancreatic progenitors changes over time, we generated transgenic mice expressing a tamoxifen-inducible Ngn3 fusion protein under the control of the pdx1 promoter and backcrossed the transgene into the ngn3(-/-) background, devoid of endogenous endocrine cells. Early activation of Ngn3-ER(TM) almost exclusively induced glucagon+ cells, while depleting the pool of pancreas progenitors. As from E11.5, Pdx1+ progenitors became competent to differentiate into insulin+ and PP+ cells. Somatostatin+ cells were generated from E14.5, while the competence to make glucagon+ cells was dramatically decreased. Hence, pancreas progenitors, similar to retinal or cortical progenitors, go through competence states that each allow the generation of a subset of cell types. We further show that the progenitors acquire competence to generate late-born cells in a mechanism that is intrinsic to the epithelium.
journal_name
Dev Celljournal_title
Developmental cellauthors
Johansson KA,Dursun U,Jordan N,Gu G,Beermann F,Gradwohl G,Grapin-Botton Adoi
10.1016/j.devcel.2007.02.010subject
Has Abstractpub_date
2007-03-01 00:00:00pages
457-65issue
3eissn
1534-5807issn
1878-1551pii
S1534-5807(07)00061-5journal_volume
12pub_type
杂志文章abstract：:Centromere chromatin containing histone H3 variant CENP-A is required for accurate chromosome segregation as a foundation for kinetochore assembly. Human centromere chromatin assembles on a part of the long α-satellite (alphoid) DNA array, where it is flanked by pericentric heterochromatin. Heterochromatin spreads int...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.05.006
更新日期：2016-06-06 00:00:00
abstract：:Since the discovery of double fertilization, it has been recognized that flowering plants produce two highly dimorphic female gametes, the egg cell and central cell. These give rise, respectively, to the embryo and the endosperm, a nourishing tissue unique to flowering plants. Here we show that in Arabidopsis, endospe...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.03.009
更新日期：2016-04-04 00:00:00
abstract：:Cell polarity plays a key role in the development of the central nervous system (CNS). Interestingly, disruption of cell polarity is seen in many cancers. ASPP2 is a haplo-insufficient tumor suppressor and an activator of the p53 family. In this study, we show that ASPP2 controls the polarity and proliferation of neur...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.06.003
更新日期：2010-07-20 00:00:00
abstract：:Dynamic rearrangements of the actin cytoskeleton play a key role in numerous cellular processes. In Drosophila, fusion between a muscle founder cell and a fusion competent myoblast (FCM) is mediated by an invasive, F-actin-enriched podosome-like structure (PLS). Here, we show that the dynamics of the PLS is controlled...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.04.007
更新日期：2011-05-17 00:00:00
abstract：:Airway smooth muscle is best known for its role as an airway constrictor in diseases such as asthma. However, its function in lung development is debated. A prevalent model, supported by in vitro data, posits that airway smooth muscle promotes lung branching through peristalsis and pushing intraluminal fluid to branch...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.02.001
更新日期：2020-04-06 00:00:00
abstract：:A remarkable feature of development is its reproducibility, the ability to correct embryo-to-embryo variations and instruct precise patterning. In Drosophila, embryonic patterning along the anterior-posterior axis is controlled by the morphogen gradient Bicoid (Bcd). In this article, we describe quantitative studies o...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.09.004
更新日期：2008-10-01 00:00:00
abstract：:Inherited mtDNA mutations cause severe human disease. In most species, mitochondria are inherited maternally through mechanisms that are poorly understood. Genes that specifically control the inheritance of mitochondria in the germline are unknown. Here, we show that the long isoform of the protein Oskar regulates the...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.11.004
更新日期：2016-12-05 00:00:00
abstract：:The complex muscle patterns of higher organisms arise as migrating myoblasts are guided toward and connect with specific attachment sites. We review here the current understanding of myotube migration, focusing on its dynamic nature and the few molecular cues that have been identified to date. Much of this knowledge c...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2004.06.010
更新日期：2004-07-01 00:00:00
abstract：:Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players. ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00298-3
更新日期：2003-10-01 00:00:00
abstract：:Sox2 expression marks neural and sensory primordia at various stages of development. A 50 kb genomic region of chicken Sox2 was isolated and scanned for enhancer activity utilizing embryo electroporation, resulting in identification of a battery of enhancers. Although Sox2 expression in the early embryonic CNS appears...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00088-1
更新日期：2003-04-01 00:00:00
abstract：:Cell-to-cell communication coordinates the behavior of individual cells to establish organ patterning and development. Although mobile signals are known to be important in lateral root development, the role of plasmodesmata (PD)-mediated transport in this process has not been investigated. Here, we show that changes i...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.06.010
更新日期：2013-07-29 00:00:00
abstract：:Cell division axes during development are specified in different orientations to establish multicellular assemblies, but the mechanisms that generate division axis diversity remain unclear. We show here that patterns of cell contact provide cues that diversify cell division orientation by modulating cortical non-muscl...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.06.020
更新日期：2018-08-06 00:00:00
abstract：:Drosophila gurken mRNA is localized by dynein-mediated transport to a crescent near the oocyte nucleus, thus targeting the TGFalpha signal and forming the primary embryonic axes. Here, we show that gurken and the I factor, a non-LTR retrotransposon, share a small consensus RNA stem loop of defined secondary structure,...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.04.012
更新日期：2005-07-01 00:00:00
abstract：:How cold-blooded animals acclimate to temperature and what determines the limits of their viable temperature range are not understood. Here, we show that Drosophila alter their dietary preference from yeast to plants when temperatures drop below 15°C and that the different lipids present in plants improve survival at ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.05.028
更新日期：2018-09-24 00:00:00
abstract：:What are the thermodynamic costs of development? In this issue of Developmental Cell, Rodenfels et al. (2019) demonstrate that the high energetic cost of coordinated cell division that is regulated by phospho-signaling gives rise to a measurable periodicity in the heat dissipated during zebrafish embryogenesis. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.02.016
更新日期：2019-03-11 00:00:00
abstract：:One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an ant...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.11.027
更新日期：2020-12-21 00:00:00
abstract：:Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2007.04.005
更新日期：2007-05-01 00:00:00
abstract：:T-box genes encode DNA binding transcription factors known to regulate a wide variety of developmental processes during embryogenesis and are present in the genomes of all multicellular animals. Indeed, alongside other more familiar families of developmental regulators such as Hox, Sox, and Pax, T-box genes constitute...
journal_title：Developmental cell
pub_type：
doi：10.1016/s1534-5807(02)00330-1
更新日期：2002-11-01 00:00:00
abstract：:Changes to cell shape and interaction drive animal tissue morphogenesis. Reporting now in Developmental Cell, Del Signore et al. (2018) describe active lengthening of cell-cell contacts by Arp2/3-based actin networks. Through cycles of contact lengthening and shortening, the developing Drosophila eye passes through va...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.02.003
更新日期：2018-02-26 00:00:00
abstract：:Cells that undergo epithelial-to-mesenchymal transitions (EMTs) commonly switch from expressing E-cadherin to N-cadherin. But why this occurs is not well understood. In the current issue of Developmental Cell, Scarpa et al. (2015) identify a reason: cadherin switching controls Rac signaling to determine how cell locom...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.08.002
更新日期：2015-08-24 00:00:00
abstract：:Theoretical modeling is central to elucidating underlying principles of emergent properties of complex systems. In cell and developmental biology, the last 15 years have witnessed a convergence of empirical and modeling approaches for fresh perspectives. The role of cell division in coordinating size, shape, and fate ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.09.008
更新日期：2016-09-26 00:00:00
abstract：:Egg production declines with age in many species, a process linked with stem cell loss. Diet-dependent signaling has emerged as critical for stem cell maintenance during aging. Follicle stem cells (FSCs) in the Drosophila ovary are exquisitely responsive to diet-induced signals including Hedgehog (Hh) and insulin-IGF ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.08.008
更新日期：2018-09-24 00:00:00
abstract：:Plasma membrane subdomains enriched in sphingolipids, cholesterol, and signaling proteins are critical for organization of actin, membrane trafficking, and cell polarity, but the role of such domains in cytokinesis in animal cells is unknown. Here, we show that eggs form a plasma membrane domain enriched in gangliosid...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.11.002
更新日期：2005-12-01 00:00:00
abstract：:Border cells in the Drosophila ovary originate within an epithelium, detach from it, invade neighboring nurse cells, and migrate as a coherent cluster. This migration has served as a useful genetic model for understanding epithelial cell motility. The prevailing model of growth factor-mediated chemotaxis in general, a...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.03.021
更新日期：2007-06-01 00:00:00
abstract：:In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targetin...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.07.026
更新日期：2014-09-08 00:00:00
abstract：:22q11 deletion (del22q11) syndrome is characterized genetically by heterozygous deletions within chromosome 22q11 and clinically by a constellation of congenital malformations of the aortic arch, heart, thymus, and parathyroid glands described as DiGeorge syndrome (DGS). Here, we report that compound heterozygosity of...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.12.002
更新日期：2006-01-01 00:00:00
abstract：:Lymphatic vessels are essential for tissue homeostasis and immune surveillance and contribute to pathological conditions. Lymphatic endothelium differentiates from veins and forms an independent vascular tree with only few connections to the venous circulation. Failure of blood and lymphatic vessel separation results ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.01.009
更新日期：2010-03-16 00:00:00
abstract：:Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2017.10.001
更新日期：2017-11-20 00:00:00
abstract：:The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the consequences of depleting breast cancer cells of SIRT1. We discovered tha...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.03.011
更新日期：2019-05-06 00:00:00
abstract：:Cell and organelle membranes consist of a complex mixture of phospholipids (PLs) that determine their size, shape, and function. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes, yet how cells sense and regulate its levels in vivo remains unclear. Here we show that PCYT1A, the rate-li...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.04.012
更新日期：2018-05-21 00:00:00
