Abstract：
:During organogenesis, coherent organ growth arises from spatiotemporally coordinated decisions of individual cells. In the root of Arabidopsis thaliana, this coordination results in the establishment of a division and a differentiation zone. Cells continuously move through these zones; thus, a major question is how the boundary between these domains, the transition zone, is formed and maintained. By combining molecular genetics with computational modeling, we reveal how an auxin/PLETHORA/ARR-B network controls these dynamic patterning processes. We show that after germination, cell division causes a drop in distal PLT2 levels that enables transition zone formation and ARR12 activation. The resulting PLT2-ARR12 antagonism controls expansion of the division zone (the meristem). The successive ARR1 activation antagonizes PLT2 through inducing the cell-cycle repressor KRP2, thus setting final meristem size. Our work indicates a key role for the interplay between cell division dynamics and regulatory networks in root zonation and transition zone patterning.
journal_name
Dev Celljournal_title
Developmental cellauthors
Salvi E,Rutten JP,Di Mambro R,Polverari L,Licursi V,Negri R,Dello Ioio R,Sabatini S,Ten Tusscher Kdoi
10.1016/j.devcel.2020.04.004subject
Has Abstractpub_date
2020-05-18 00:00:00pages
431-443.e23issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(20)30271-9journal_volume
53pub_type
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