Reconsidering the Passive Diffusion Model of Steroid Hormone Cellular Entry.

abstract：:All complex multicellular organisms must solve the problem of generating diverse and appropriately patterned cell types. Asymmetric division, in which a single mother cell gives rise to daughters with distinct identities, is instrumental in the generation of cellular diversity and higher-level patterns. In animal syst...

journal_title：Developmental cell

authors： Abrash EB,Bergmann DC

更新日期：2009-06-01 00:00:00

abstract：:Developmental growth requires coordination between the growth rates of individual tissues and organs. Here, we examine how Drosophila neuromuscular synapses grow to match the size of their target muscles. We show that changes in muscle growth driven by autonomous modulation of insulin receptor signaling produce corres...

journal_title：Developmental cell

authors： Ho CH,Treisman JE

更新日期：2020-07-06 00:00:00

abstract：:In response to cellular stress, mitochondria remodel their structure by organelle division and fusion. In this issue of Developmental Cell, Cooper et al. (2014) report that a nuclear protein, cyclin C, is recruited from nuclei to mitochondria upon oxidative stress and promotes mitochondrial division and apoptosis of t...

journal_title：Developmental cell

authors： Adachi Y,Sesaki H

更新日期：2014-01-27 00:00:00

abstract：:The gastrulating vertebrate embryo develops three germlayers: ectoderm, mesoderm, and endoderm. Zebrafish endoderm differentiation starts with the activation of sox17 by casanova (cas). We report that spg (pou2/Oct4) is essential for endoderm formation. Embryos devoid of maternal and zygotic spg function (MZspg) lack ...

journal_title：Developmental cell

authors： Reim G,Mizoguchi T,Stainier DY,Kikuchi Y,Brand M

更新日期：2004-01-01 00:00:00

abstract：:Protein transport between the ER and the Golgi in mammalian cells occurs via large pleiomorphic carriers, and most current models suggest that these are formed by the fusion of small ER-derived COPII vesicles. We have examined the dynamics and structural features of these carriers during and after their formation from...

journal_title：Developmental cell

authors： Mironov AA,Mironov AA Jr,Beznoussenko GV,Trucco A,Lupetti P,Smith JD,Geerts WJ,Koster AJ,Burger KN,Martone ME,Deerinck TJ,Ellisman MH,Luini A

更新日期：2003-10-01 00:00:00

abstract：:Several genes have been implicated in heart tube formation, yet we know little about underlying cellular mechanisms. We analyzed the cellular architecture of the migrating myocardial precursors, and find that they form coherent epithelia that mature as they move medially. Mutant analyses indicate that the cardia bifid...

journal_title：Developmental cell

authors： Trinh LA,Stainier DY

更新日期：2004-03-01 00:00:00

abstract：:The anterior visceral endoderm plays a pivotal role in establishing anterior-posterior polarity of the mouse embryo, but the molecular nature of the signals required remains to be determined. Here, we demonstrate that Cerberus-like(-/-);Lefty1(-/-) compound mutants can develop a primitive streak ectopically in the emb...

journal_title：Developmental cell

authors： Perea-Gomez A,Vella FD,Shawlot W,Oulad-Abdelghani M,Chazaud C,Meno C,Pfister V,Chen L,Robertson E,Hamada H,Behringer RR,Ang SL

更新日期：2002-11-01 00:00:00

abstract：:Unravelling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulations. In this issue of Developmental Cell, Cerikan et al. (2016) reveal how acute effects of DOCK6 RhoGEF depletion on RAC1 and CDC42 activation are reversed over time by compensatory mechanisms that re-establish...

journal_title：Developmental cell

authors： McGarry DJ,Olson MF

更新日期：2016-10-10 00:00:00

abstract：:Understanding the mechanisms driving tissue and organ formation requires knowledge across scales. How do signaling pathways specify distinct tissue types? How does the patterning system control morphogenesis? How do these processes evolve? The Drosophila egg chamber, where EGF and BMP signaling intersect to specify un...

journal_title：Developmental cell

authors： Osterfield M,Berg CA,Shvartsman SY

更新日期：2017-05-22 00:00:00

abstract：:The Par polarity complex creates mutually exclusive cortical domains in diverse animal cells. Activity of the atypical protein kinase C (aPKC) is a key output of the Par complex as phosphorylation removes substrates from the Par domain. Here, we investigate how diverse, apparently unrelated Par substrates couple phosp...

journal_title：Developmental cell

authors： Bailey MJ,Prehoda KE

更新日期：2015-10-26 00:00:00

abstract：:In the field of breast biology, there is a growing appreciation for the "gatekeeping function" of basal cells during development and disease processes yet mechanisms regulating the generation of these cells are poorly understood. Here, we report that the proliferation of basal cells is controlled by SLIT/ROBO1 signali...

journal_title：Developmental cell

authors： Macias H,Moran A,Samara Y,Moreno M,Compton JE,Harburg G,Strickland P,Hinck L

更新日期：2011-06-14 00:00:00

abstract：:Manipulation of cellular identity in the laboratory is generally inefficient due to stochastic events, including epigenomic alterations. Recently in Science, Zuryn et al. (2014) demonstrate that the efficiency of a naturally occurring transdifferentiation event in Caenorhabditis elegans is ensured through stepwise epi...

journal_title：Developmental cell

authors： Beyret E,Izpisua Belmonte JC

更新日期：2014-09-29 00:00:00

abstract：:Alzheimer's disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that "designer" molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligo...

journal_title：Developmental cell

authors： Singh JK,Balch WE

更新日期：2015-03-23 00:00:00

abstract：:Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during mitosis-a process termed centrosome maturation. How centrosomes mature remains mysterious. Here, we identify a domain in Drosophila Cnn that appears to be phospho...

journal_title：Developmental cell

authors： Conduit PT,Feng Z,Richens JH,Baumbach J,Wainman A,Bakshi SD,Dobbelaere J,Johnson S,Lea SM,Raff JW

更新日期：2014-03-31 00:00:00

abstract：:Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the E...

journal_title：Developmental cell

authors： Henne WM,Buchkovich NJ,Emr SD

更新日期：2011-07-19 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive features underlined by major transcriptional and epigenetic reprogramming. However, most studies have focused on the endpoints of the EMT process, and the epistatic hierarchy of the transcriptional networks underlying EMT has remained...

journal_title：Developmental cell

authors： Meyer-Schaller N,Cardner M,Diepenbruck M,Saxena M,Tiede S,Lüönd F,Ivanek R,Beerenwinkel N,Christofori G

更新日期：2019-02-25 00:00:00

abstract：:Reporting in Nature, Sanders et al. (2013) implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb. Actin-based filopodia transport Shh from producing cells, while filopodia of responding cells bear Cdon and Boc: coreceptors in the Shh pathway. These findings suggest a new mechanism of ligand m...

journal_title：Developmental cell

authors： McMahon AP,Hasso SM

更新日期：2013-05-28 00:00:00

abstract：:Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types. This is especially critical during embryogenesis, when extensive cell proliferation, patterning, and migration events take place. Here we show that vertebrate primordial germ cells (PGCs) are pr...

journal_title：Developmental cell

authors： Gross-Thebing T,Yigit S,Pfeiffer J,Reichman-Fried M,Bandemer J,Ruckert C,Rathmer C,Goudarzi M,Stehling M,Tarbashevich K,Seggewiss J,Raz E

更新日期：2017-12-18 00:00:00

abstract：:During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell-cycle progression, and cytokinesis. Rac1 null cells migrate markedly less efficiently, but s...

journal_title：Developmental cell

authors： Li A,Ma Y,Yu X,Mort RL,Lindsay CR,Stevenson D,Strathdee D,Insall RH,Chernoff J,Snapper SB,Jackson IJ,Larue L,Sansom OJ,Machesky LM

更新日期：2011-10-18 00:00:00

abstract：:Elucidating chromatin's 3D shape is critical to understanding its function, but the fine structure of chromatin domains remains poorly resolved. In a recent report in Nature, Boettiger et al. (2016) visualize chromatin in super-resolution, gaining unprecedented insight into chromatin architecture. ...

journal_title：Developmental cell

authors： Finn EH,Misteli T,Shachar S

更新日期：2016-02-22 00:00:00

abstract：:The Hox family transcription factors control diversified morphogenesis during development and evolution. They function in concert with Pbc cofactor proteins. Pbc proteins bind the Hox hexapeptide (HX) motif and are thereby thought to confer DNA binding specificity. Here we report that mutation of the AbdA HX motif doe...

journal_title：Developmental cell

authors： Merabet S,Kambris Z,Capovilla M,Bérenger H,Pradel J,Graba Y

更新日期：2003-05-01 00:00:00

abstract：:Many different intercellular signaling pathways are known but, for most, it is unclear whether they can generate oscillating cell behaviors. Here we use time-lapse analysis of Drosophila embryogenesis to show that oenocytes delaminate from the ectoderm in discrete bursts of three. This pulsatile process has a 1 hour p...

journal_title：Developmental cell

authors： Brodu V,Elstob PR,Gould AP

更新日期：2004-12-01 00:00:00

abstract：:Axon guidance at the Drosophila midline relies on dynamic regulation of the guidance receptor Robo by its negative regulator Comm. Recent findings demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo signaling by promoting the sorting of Robo into the endocytic pathway. ...

journal_title：Developmental cell

authors： Rosenzweig M,Garrity P

更新日期：2002-09-01 00:00:00

abstract：:Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...

journal_title：Developmental cell

authors： Ewen-Campen B,Mohr SE,Hu Y,Perrimon N

更新日期：2017-10-09 00:00:00

abstract：:The Cubitus interruptus (Ci)/Gli family of transcription factors can be degraded either completely or partially from a full-length form (Ci155/Gli(FL)) to a truncated repressor (Ci75/Gli(R)) by proteasomes to mediate Hedgehog (Hh) signaling. The mechanism by which proteasomes distinguish ubiquitinated Ci/Gli to carry ...

journal_title：Developmental cell

authors： Zhang Z,Lv X,Yin WC,Zhang X,Feng J,Wu W,Hui CC,Zhang L,Zhao Y

更新日期：2013-06-24 00:00:00

abstract：:The Drosophila gene neuralized (neur) has long been recognized to be essential for the proper execution of a wide variety of processes mediated by the Notch (N) pathway, but its role in the pathway has been elusive. In this report, we present genetic and biochemical evidence that Neur is a RING-type, E3 ubiquitin liga...

journal_title：Developmental cell

authors： Lai EC,Deblandre GA,Kintner C,Rubin GM

更新日期：2001-12-01 00:00:00

abstract：:The connection between cell fate transitions and metabolic shifts is gaining momentum in the study of cell differentiation in embryonic development, adult stem cells, and cancer pathogenesis. Here, we explore how metabolic transitions influence post-translational modifications (PTMs), which play central roles in the a...

journal_title：Developmental cell

authors： Tarazona OA,Pourquié O

更新日期：2020-07-20 00:00:00

abstract：:22q11 deletion (del22q11) syndrome is characterized genetically by heterozygous deletions within chromosome 22q11 and clinically by a constellation of congenital malformations of the aortic arch, heart, thymus, and parathyroid glands described as DiGeorge syndrome (DGS). Here, we report that compound heterozygosity of...

journal_title：Developmental cell

authors： Guris DL,Duester G,Papaioannou VE,Imamoto A

更新日期：2006-01-01 00:00:00

abstract：:Dynein recruitment to the nuclear envelope is required for pre-mitotic nucleus-centrosome interactions in nonneuronal cells and for apical nuclear migration in neural stem cells. In each case, dynein is recruited to the nuclear envelope (NE) specifically during G2 via two nuclear pore-mediated mechanisms involving Ran...

journal_title：Developmental cell

authors： Baffet AD,Hu DJ,Vallee RB

更新日期：2015-06-22 00:00:00

abstract：:Appropriate patterns of DNA methylation and histone modifications are required to assure cell identity, and their deregulation can contribute to human diseases, such as cancer. Our aim here is to provide an overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and microRNA regul...

journal_title：Developmental cell

authors： Berdasco M,Esteller M

更新日期：2010-11-16 00:00:00