Fibronectin regulates epithelial organization during myocardial migration in zebrafish.

Abstract:

:Several genes have been implicated in heart tube formation, yet we know little about underlying cellular mechanisms. We analyzed the cellular architecture of the migrating myocardial precursors, and find that they form coherent epithelia that mature as they move medially. Mutant analyses indicate that the cardia bifida locus natter (nat) is required for the integrity of the myocardial epithelia. We positionally cloned nat and show that it encodes Fibronectin. During myocardial migration, Fibronectin is deposited at the midline between the endoderm and endocardial precursors, and laterally around the myocardial precursors. Further analyses show that Fibronectin deposition at the midline is required for the timely migration of myocardial precursors, but dispensable for the migration process itself. In the complete absence of Fibronectin, adherens junctions between myocardial precursors do not form properly, suggesting that cell-substratum interactions are required for epithelial organization. These data suggest that myocardial migration is dependent on epithelial integrity.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Trinh LA,Stainier DY

doi

10.1016/s1534-5807(04)00063-2

keywords:

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

371-82

issue

3

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(04)00063-2

journal_volume

6

pub_type

杂志文章
  • Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms.

    abstract::Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associated RNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear whether it plays any roles in early GSC...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2017.03.023

    authors: Ma X,Zhu X,Han Y,Story B,Do T,Song X,Wang S,Zhang Y,Blanchette M,Gogol M,Hall K,Peak A,Anoja P,Xie T

    更新日期:2017-04-24 00:00:00

  • miRNA in embryonic development: the taming of Nodal signaling.

    abstract::The TGF-beta family member Nodal is one of the most potent molecules known to an embryo. Studies on Nodal regulation thus far have focused on its transcription, maturation, and interaction with antagonists. Two recent studies on the role of microRNAs (miRNAs) in Nodal signaling now reveal that something important was ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2007.09.012

    authors: Collignon J

    更新日期:2007-10-01 00:00:00

  • How to Make a Billion Parasites.

    abstract::Transmission of the human parasite Brugia malayi relies on the sustained production of larvae in blood. In this issue of Developmental Cell,Foray et al. (2018) use methods developed in the model nematode C. elegans to reveal how a symbiotic bacterium supports the female germ cell development underlying this massive fe...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2018.04.006

    authors: Haag ES,Lo TW

    更新日期:2018-04-23 00:00:00

  • KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.

    abstract::Centromere chromatin containing histone H3 variant CENP-A is required for accurate chromosome segregation as a foundation for kinetochore assembly. Human centromere chromatin assembles on a part of the long α-satellite (alphoid) DNA array, where it is flanked by pericentric heterochromatin. Heterochromatin spreads int...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.05.006

    authors: Ohzeki J,Shono N,Otake K,Martins NM,Kugou K,Kimura H,Nagase T,Larionov V,Earnshaw WC,Masumoto H

    更新日期:2016-06-06 00:00:00

  • Dystroglycan and AMP kinase: polarity's protectors when the power goes out.

    abstract::The AMP-stimulated protein kinase regulates epithelial polarity under conditions of energy depletion by phosphorylating the myosin regulatory light chain. In this issue of Developmental Cell, Mirouse et al. demonstrate that dystroglycan and perlecan, an extracellular matrix receptor and its ligand, help localize myosi...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2008.12.004

    authors: Zhang L,Seo-Mayer P,Caplan MJ

    更新日期:2009-01-01 00:00:00

  • p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate.

    abstract::The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.02.005

    authors: Nyeng P,Heilmann S,Löf-Öhlin ZM,Pettersson NF,Hermann FM,Reynolds AB,Semb H

    更新日期:2019-04-08 00:00:00

  • Rsp1p, a J domain protein required for disassembly and assembly of microtubule organizing centers during the fission yeast cell cycle.

    abstract::Regulation of microtubule organizing centers (MTOCs) orchestrates the reorganization of the microtubule (MT) cytoskeleton. In the fission yeast Schizosaccharomyces pombe, an equatorial MTOC (eMTOC) at the cell division site disassembles after cytokinesis, and multiple interphase MTOCs (iMTOCs) appear on the nucleus. H...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(04)00096-6

    authors: Zimmerman S,Tran PT,Daga RR,Niwa O,Chang F

    更新日期:2004-04-01 00:00:00

  • Dynamic Control of dNTP Synthesis in Early Embryos.

    abstract::Exponential increase of cell numbers in early embryos requires large amounts of DNA precursors (deoxyribonucleoside triphosphates (dNTPs)). Little is understood about how embryos satisfy this demand. We examined dNTP metabolism in the early Drosophila embryo, in which gastrulation is preceded by 13 sequential nuclear ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2017.06.013

    authors: Song Y,Marmion RA,Park JO,Biswas D,Rabinowitz JD,Shvartsman SY

    更新日期:2017-08-07 00:00:00

  • Toward a new twist in Hox and TALE DNA-binding specificity.

    abstract::Hox proteins gain specificity by interacting with TALE-class cofactors. In a recent issue of Cell and in this issue of Developmental Cell, Crocker et al. (2015) and Amin et al. (2015), respectively, demonstrate that non-canonical Hox/TALE binding sequences play a major role in the regionalized regulation of target gen...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2015.01.030

    authors: Merabet S,Lohmann I

    更新日期:2015-02-09 00:00:00

  • Mitotic spindle orientation: semaphorin-plexin signaling flags the way.

    abstract::The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney deve...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2015.04.012

    authors: Humbert PO,Gödde NJ

    更新日期:2015-05-04 00:00:00

  • The bacterial cytoskeleton: in vivo dynamics of the actin-like protein Mbl of Bacillus subtilis.

    abstract::Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(02)00403-3

    authors: Carballido-López R,Errington J

    更新日期:2003-01-01 00:00:00

  • Functional diversification of Dicer-like proteins and small RNAs required for genome sculpting.

    abstract::In eukaryotes, small RNAs (sRNAs) have key roles in development, gene expression regulation, and genome integrity maintenance. In ciliates, such as Paramecium, sRNAs form the heart of an epigenetic system that has evolved from core eukaryotic gene silencing components to selectively target DNA for deletion. In Paramec...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.12.010

    authors: Sandoval PY,Swart EC,Arambasic M,Nowacki M

    更新日期:2014-01-27 00:00:00

  • Fate mapping embryonic blood in zebrafish: multi- and unipotential lineages are segregated at gastrulation.

    abstract::Vertebrate hematopoiesis first produces primitive (embryonic) lineages and ultimately generates the definitive (adult) blood. Whereas definitive hematopoiesis may produce many diverse blood types via a common multipotent progenitor, primitive hematopoiesis has been thought to produce only erythrocytes or macrophages v...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.04.007

    authors: Warga RM,Kane DA,Ho RK

    更新日期:2009-05-01 00:00:00

  • HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.

    abstract::The genetic networks that govern vertebrate development are well studied, but how the interactions of trans-acting factors with cis-regulatory modules (CRMs) are integrated into spatiotemporal regulation of gene expression is not clear. The transcriptional regulator HAND2 is required during limb, heart, and branchial ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2014.09.018

    authors: Osterwalder M,Speziale D,Shoukry M,Mohan R,Ivanek R,Kohler M,Beisel C,Wen X,Scales SJ,Christoffels VM,Visel A,Lopez-Rios J,Zeller R

    更新日期:2014-11-10 00:00:00

  • Stopped in translation: EMT control meets eukaryotic elongation.

    abstract::Recently reporting in Molecular Cell, Hussey et al. (2011) find that hnRNP E1 inhibits the translation of several genes essential for the epithelial-to-mesenchymal transition (EMT) by blocking eEF1A1 release during translation elongation. Phosphorylation of hnRNP E1 in response to TGF-β signaling disrupts the hnRNP E1...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2011.02.012

    authors: Zhang YE

    更新日期:2011-03-15 00:00:00

  • Rho Flares Repair Local Tight Junction Leaks.

    abstract::Tight junctions contribute to epithelial barrier function by selectively regulating the quantity and type of molecules that cross the paracellular barrier. Experimental approaches to evaluate the effectiveness of tight junctions are typically global, tissue-scale measures. Here, we introduce Zinc-based Ultrasensitive ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.01.016

    authors: Stephenson RE,Higashi T,Erofeev IS,Arnold TR,Leda M,Goryachev AB,Miller AL

    更新日期:2019-02-25 00:00:00

  • Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression.

    abstract::Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in regulation of both the Hippo-Yap and Rac1-Pak1 pathways. Using genetically engineered murine liver models, we show that co-deletion of Rac1 with Nf2 blocks tumor initiation but paradoxically exacerbates hepatomegaly induced by N...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.09.027

    authors: Shi Y,Bollam SR,White SM,Laughlin SZ,Graham GT,Wadhwa M,Chen H,Nguyen C,Vitte J,Giovannini M,Toretsky J,Yi C

    更新日期:2016-11-21 00:00:00

  • Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration.

    abstract::Directional cell migration is critical for metazoan development. We define two molecular pathways that activate the Arp2/3 complex during neuroblast migration in Caenorhabditis elegans. The transmembrane protein MIG-13/Lrp12 is linked to the Arp2/3 nucleation-promoting factors WAVE or WASP through direct interactions ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.09.029

    authors: Zhu Z,Chai Y,Jiang Y,Li W,Hu H,Li W,Wu JW,Wang ZX,Huang S,Ou G

    更新日期:2016-10-24 00:00:00

  • N-WASP Guides Cancer Cells toward LPA.

    abstract::The actin remodeling factor N-WASP is best known as an Arp2/3 complex activator in processes like endocytosis, extracellular matrix degradation, and host-pathogen interaction. In this issue of Developmental Cell, Juin et al. establish a novel trafficking function for N-WASP in driving lysophosphatidic acid-dependent c...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2019.10.029

    authors: Rottner K,Schaks M

    更新日期:2019-11-18 00:00:00

  • How to grab a microtubule on the move.

    abstract::In migrating cells, Rho family GTPases and their effectors play a central role in polarizing and in organizing the actin and microtubule cytoskeletons. A study by Fukata et al. in the June 28th issue of Cell now shows that the Rac1/Cdc42 effector IQGAP1 captures microtubules by binding to CLIP170. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章,评审

    doi:10.1016/s1534-5807(02)00209-5

    authors: Brunner D

    更新日期:2002-07-01 00:00:00

  • EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality.

    abstract::Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.10.009

    authors: Cayuso J,Dzementsei A,Fischer JC,Karemore G,Caviglia S,Bartholdson J,Wright GJ,Ober EA

    更新日期:2016-11-07 00:00:00

  • Coping with Loss: Cell Adaptation to Cytoskeleton Disruption.

    abstract::Unravelling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulations. In this issue of Developmental Cell, Cerikan et al. (2016) reveal how acute effects of DOCK6 RhoGEF depletion on RAC1 and CDC42 activation are reversed over time by compensatory mechanisms that re-establish...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2016.09.020

    authors: McGarry DJ,Olson MF

    更新日期:2016-10-10 00:00:00

  • The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression.

    abstract::Passenger proteins migrate from inner centromeres to the spindle midzone during late mitosis, and those described to date are essential both for proper chromosome segregation and for completion of cell cleavage. We have purified and cloned the human passenger protein TD-60, and we here report that it is a member of th...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(03)00205-3

    authors: Mollinari C,Reynaud C,Martineau-Thuillier S,Monier S,Kieffer S,Garin J,Andreassen PR,Boulet A,Goud B,Kleman JP,Margolis RL

    更新日期:2003-08-01 00:00:00

  • Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models.

    abstract::Appropriate axonal growth and connectivity are essential for functional wiring of the brain. Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations disrupt primary cilia function, are characterized by axonal tract malformations. However, little is known about how cilia-driven signaling r...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.11.005

    authors: Guo J,Otis JM,Suciu SK,Catalano C,Xing L,Constable S,Wachten D,Gupton S,Lee J,Lee A,Blackley KH,Ptacek T,Simon JM,Schurmans S,Stuber GD,Caspary T,Anton ES

    更新日期:2019-12-16 00:00:00

  • Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche.

    abstract::Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2017.10.001

    authors: Gonzales KAU,Fuchs E

    更新日期:2017-11-20 00:00:00

  • Structural architecture and functional evolution of Wnts.

    abstract::The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds. ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2012.07.011

    authors: Bazan JF,Janda CY,Garcia KC

    更新日期:2012-08-14 00:00:00

  • Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche.

    abstract::The gut absorbs dietary nutrients and provides a barrier to xenobiotics and microbiome metabolites. To cope with toxin exposures, the intestinal epithelium is one of the most rapidly proliferating tissues in the body. The stem cell niche supplies essential signaling factors including Wnt proteins secreted by subepithe...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.07.023

    authors: Chee YC,Pahnke J,Bunte R,Adsool VA,Madan B,Virshup DM

    更新日期:2018-09-24 00:00:00

  • Autophagosome formation: tracing the source.

    abstract::Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki et al. (2013) suggest that the ER-...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2013.04.004

    authors: Bernard A,Klionsky DJ

    更新日期:2013-04-29 00:00:00

  • An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles.

    abstract::In vertebrates, the microtubule binding protein TPX2 is required for meiotic and mitotic spindle assembly. TPX2 is also known to bind to and activate Aurora A kinase and target it to the spindle. However, the relationship between the TPX2-Aurora A interaction and the role of TPX2 in spindle assembly is unclear. Here, ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2005.07.002

    authors: Ozlü N,Srayko M,Kinoshita K,Habermann B,O'toole ET,Müller-Reichert T,Schmalz N,Desai A,Hyman AA

    更新日期:2005-08-01 00:00:00

  • Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway.

    abstract::The regulated release of polypeptides has a central role in physiology, behavior, and development, but the mechanisms responsible for production of the large dense core vesicles (LDCVs) capable of regulated release have remained poorly understood. Recent work has implicated cytosolic adaptor protein AP-3 in the recrui...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.10.007

    authors: Asensio CS,Sirkis DW,Maas JW Jr,Egami K,To TL,Brodsky FM,Shu X,Cheng Y,Edwards RH

    更新日期:2013-11-25 00:00:00