Abstract：
:The Drosophila gene neuralized (neur) has long been recognized to be essential for the proper execution of a wide variety of processes mediated by the Notch (N) pathway, but its role in the pathway has been elusive. In this report, we present genetic and biochemical evidence that Neur is a RING-type, E3 ubiquitin ligase. Next, we show that neur is required for proper internalization of Dl in the developing eye. Finally, we demonstrate that ectopic Neur targets Dl for internalization and degradation in a RING finger-dependent manner, and that the two exist in a physical complex. Collectively, our data indicate that Neur is a ubiquitin ligase that positively regulates the N pathway by promoting the endocytosis and degradation of Dl.
journal_name
Dev Celljournal_title
Developmental cellauthors
Lai EC,Deblandre GA,Kintner C,Rubin GMdoi
10.1016/s1534-5807(01)00092-2keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
783-94issue
6eissn
1534-5807issn
1878-1551pii
S1534-5807(01)00092-2journal_volume
1pub_type
杂志文章abstract：:Stem cell differentiation involves a delicate balance of gene expression and transposon repression. In this issue of Developmental Cell, Shibata et al. (2016) show that a PIWI protein expressed in planarian stem cells is inherited by their differentiating descendants to ensure regenerative capacity of the flatworm via...
journal_title：Developmental cell
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abstract：:Angiogenesis is responsible for tissue vascularization during development, as well as in pathological contexts, including cancer and ischemia. Vascular endothelial growth factors (VEGFs) regulate angiogenesis by acting through VEGF receptors to induce endothelial cell signaling. VEGF is processed in the extracellular ...
journal_title：Developmental cell
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abstract：:The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids once all chromosomes are attached via kinetochores by microtubules of the mitotic spindle. Reporting in Developmental Cell, Silió et al. (2015) show that in human cells the signaling cascade controlling the checkpoint ope...
journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2003-11-01 00:00:00
abstract：:Smad4 is a central intracellular effector of TGF-beta signaling. Smad-independent TGF-beta pathways, such as those mediated by p38 MAPK, have been identified in cell culture systems, but their in vivo functional mechanisms remain unclear. In this study, we investigated the role of TGF-beta signaling in tooth and palat...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.06.004
更新日期：2008-08-01 00:00:00
abstract：:In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes an...
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
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更新日期：2020-09-28 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.03.011
更新日期：2011-04-19 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章,评审
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更新日期：2009-03-01 00:00:00
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journal_title：Developmental cell
pub_type：
doi：10.1016/s1534-5807(02)00299-x
更新日期：2002-10-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.07.011
更新日期：2012-08-14 00:00:00
abstract：:The function of local protein synthesis in synaptic plasticity and its dysregulation in fragile X syndrome (FXS) is well studied, however the contribution of regulated mRNA transport to this function remains unclear. We report a function for the fragile X mental retardation protein (FMRP) in the rapid, activity-regula...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.04.003
更新日期：2008-06-01 00:00:00
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journal_title：Developmental cell
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abstract：:Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited by the time required to generate stable mutant lines. We describe a system for gene knockout that consistently produces null phenotypes in G0 zebrafish. Yolk injection of sets of four CRISPR/Cas9 ribonucleoprotein complexes redu...
journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2018-07-02 00:00:00
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
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journal_title：Developmental cell
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abstract：:Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here, we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacial development. Str...
journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
