Abstract:
:The function of local protein synthesis in synaptic plasticity and its dysregulation in fragile X syndrome (FXS) is well studied, however the contribution of regulated mRNA transport to this function remains unclear. We report a function for the fragile X mental retardation protein (FMRP) in the rapid, activity-regulated transport of mRNAs important for synaptogenesis and plasticity. mRNAs were deficient in glutamatergic signaling-induced dendritic localization in neurons from Fmr1 KO mice, and single mRNA particle dynamics in live neurons revealed diminished kinesis. Motor-dependent translocation of FMRP and cognate mRNAs involved the C terminus of FMRP and kinesin light chain, and KO brain showed reduced kinesin-associated mRNAs. Acute suppression of FMRP and target mRNA transport in WT neurons resulted in altered filopodia-spine morphology that mimicked the FXS phenotype. These findings highlight a mechanism for stimulus-induced dendritic mRNA transport and link its impairment in a mouse model of FXS to altered developmental morphologic plasticity.
journal_name
Dev Celljournal_title
Developmental cellauthors
Dictenberg JB,Swanger SA,Antar LN,Singer RH,Bassell GJdoi
10.1016/j.devcel.2008.04.003subject
Has Abstractpub_date
2008-06-01 00:00:00pages
926-39issue
6eissn
1534-5807issn
1878-1551pii
S1534-5807(08)00166-4journal_volume
14pub_type
杂志文章abstract::The ability of cells to form and release multiple classes of extracellular vesicles (EVs) is an increasingly well-recognized phenomenon. EVs are best known as mediators of intercellular communication. However, in a recent issue of Nature, Keller et al. show that they function as decoys to mitigate bacterial toxins. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
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journal_title:Developmental cell
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journal_title:Developmental cell
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abstract::Many different intercellular signaling pathways are known but, for most, it is unclear whether they can generate oscillating cell behaviors. Here we use time-lapse analysis of Drosophila embryogenesis to show that oenocytes delaminate from the ectoderm in discrete bursts of three. This pulsatile process has a 1 hour p...
journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 杂志文章,评审
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journal_title:Developmental cell
pub_type: 杂志文章
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journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 杂志文章,评审
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journal_title:Developmental cell
pub_type: 杂志文章,评审
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.10.004
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journal_title:Developmental cell
pub_type: 杂志文章
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abstract::Local translation allows spatial control of gene expression. Here, we performed a dual protein-mRNA localization screen, using smFISH on 523 human cell lines expressing GFP-tagged genes. 32 mRNAs displayed specific cytoplasmic localizations with local translation at unexpected locations, including cytoplasmic protrusi...
journal_title:Developmental cell
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journal_title:Developmental cell
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doi:10.1016/j.devcel.2006.02.018
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.05.011
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00170-3
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journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
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