CNS myelin wrapping is driven by actin disassembly.

Abstract:

:Myelin is essential in vertebrates for the rapid propagation of action potentials, but the molecular mechanisms driving its formation remain largely unknown. Here we show that the initial stage of process extension and axon ensheathment by oligodendrocytes requires dynamic actin filament assembly by the Arp2/3 complex. Unexpectedly, subsequent myelin wrapping coincides with the upregulation of actin disassembly proteins and rapid disassembly of the oligodendrocyte actin cytoskeleton and does not require Arp2/3. Inducing loss of actin filaments drives oligodendrocyte membrane spreading and myelin wrapping in vivo, and the actin disassembly factor gelsolin is required for normal wrapping. We show that myelin basic protein, a protein essential for CNS myelin wrapping whose role has been unclear, is required for actin disassembly, and its loss phenocopies loss of actin disassembly proteins. Together, these findings provide insight into the molecular mechanism of myelin wrapping and identify it as an actin-independent form of mammalian cell motility.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Zuchero JB,Fu MM,Sloan SA,Ibrahim A,Olson A,Zaremba A,Dugas JC,Wienbar S,Caprariello AV,Kantor C,Leonoudakis D,Lariosa-Willingham K,Kronenberg G,Gertz K,Soderling SH,Miller RH,Barres BA

doi

10.1016/j.devcel.2015.06.011

subject

Has Abstract

pub_date

2015-07-27 00:00:00

pages

152-67

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(15)00400-1

journal_volume

34

pub_type

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